Black Opal Ventures — Full Portfolio

Twist Bioscience develops a silicon-based synthetic DNA manufacturing platform that produces high-quality DNA, genes, and NGS reagents for customers in medicine, agriculture, and industrial chemicals.

BiotechDeep TechSemiconductorsSouth San Francisco, US

William Charles Banyai(Executive Officer, Director, Promoter)BJBill James Peck(Executive Officer, Promoter)ELEmily Leproust(Founder)inEmily Leproust, PhD(CEO and Co-Founder of Twist)PFPatrick Finn(President and Chief Operating Officer)inALAdam Laponis(Chief Financial Officer)in

Co-investors+N+ND Capital3E3E Bioventures CapitalARARCH Venture PartnersASAsset Management CompanyATATEL VenturesBABay City Capital+10 more

Eridu develops networking infrastructure optimized for artificial intelligence workloads.

AI & Machine LearningCloud ComputingDeep TechHardwareSaratoga, US

DPDrew Perkins(Co-founder and CEO)inBKBrian Kinard(Executive Officer)in

BoardJagdeep Singh(Director)Dipender Saluja(Director)WHWen Hsieh(Director)inChristian Gallagher(Director)

Co-investorsBOBosch VenturesCACatapult VenturesMAMatter Venture PartnersOUOUP (Osage University Partners)SOSocratic PartnersTDTDK Ventures+13 more

Ansa provides an enzymatic DNA synthesis platform that directly synthesizes complex sequences up to 900 bp and delivers constructs up to 50 kb without assembly-based methods.

BiotechDeep TechHealthtechEmeryville, US

DLDan Lin-Arlow(Founder)inSPSebastian Palluk(Founder)inDHDaniel Hillel Lin-Arlow(Executive Officer, Director)JTJason T. Gammack(Executive Officer, Director)inDaniel Lin-Arlow(Founder)Jared Ellefson(Founder)

Co-investorsCACarbon SiliconCECerberus VenturesDADauntless VenturesFIFifty YearsJUJude GomilaMEMetaplanet+14 more

AuthMind develops an AI-powered identity security platform that identifies and prevents identity access risks across on-premises and cloud applications, targeting enterprise organizations.

AI & Machine LearningCloud ComputingCybersecurityEnterprise SoftwareBethesda, US

SYShlomi Yanai(Co-Founder and CEO)inAPAnkur Panchbudhe(Co-Founder and CTO)inShlomo Yanay(Executive Officer, Director)APAnkur Purushottam Parchbudhe(Executive Officer, Director)

BoardJacob Seid(Director)

Co-investorsBABallistic VenturesCHCheyenne VenturesTETeam Builder VenturesBLBlu Venture InvestorsK2K2 Access Fund

Chamber provides care coordination software for healthcare systems operating under value-based care models, with a specific focus on improving cardiovascular outcomes through better data alignment and team coordination.

Digital HealthEnterprise SoftwareHealthtech

George Aloth(Co-Founder & CEO)Jeffrey De Flavio(Founder)Sameer Sheth(Co-Founder, President & CMO)

Co-investorsALAlleyCorpAMAmerican Family VenturesCICity LightFRFrist Cressey VenturesGEGeneral CatalystOPOptum Ventures+2 more

Thesis is an AI research lab that automates AI research and development through autonomous experimentation.

Advanced ManufacturingAI & Machine LearningDeep TechEnterprise SoftwareRoboticsSan Francisco, US

SCSergio Charles(CEO)inLCLuigi Charles(Founder)in

Co-investorsGLGlobivestRERebel FundY Y CombinatorCRCRV (Charles River Ventures)LILink VenturesLILiquid Ventures+4 more

Empatica offers an FDA-cleared health monitoring platform combining medical wearables and digital biomarkers to collect continuous, clinical-quality health data from daily life.

AI & Machine LearningDigital HealthHealthtechMedical DevicesCambridge, US

RPRosalind Picard(Founder)inMLMatteo Lai(Executive Officer, Director)inSTSimone Tognetti(Director)inLPLen Picard(Executive Officer, Director)inMario Scuderi(Director)

Co-investorsCDCDP Venture CapitalRARA CapitalSASanofi VenturesINInnogest Capital

Healthier Capital is a venture capital firm that invests in technology-enabled healthcare companies seeking to reduce costs and improve care delivery.

Digital HealthFintechHealthtech

ADAmir Dan Rubin(CEO and Founding Managing Partner)in

Co-investorsMOModi VenturesDEDefine VenturesMAMacquarie CapitalMAMaverick VenturesNONorwest Venture PartnersONOncology Ventures+2 more

Plug-and-play conversational AI platform enabling voice and chat interactions with information across digital channels.

IKIsrael Krush(Founder)inRCRom Cohen(Founder)inUri Valevski(Founder)

Co-investorsDEDefine VenturesDODorm RoomENEntrepreneurs Roundtable Accelerator (ERA)HAHanaco Venture CapitalHEHealthier CapitalK2K20 Fund+9 more

ISAAC provides an active, non-invasive structural protection system based on a patented Active Mass Damper installed on building roofs to improve seismic safety and vibration control with real-time monitoring.

Construction TechIoTPropTech

Co-investorsAXAxon Partners GroupNONovaCapitalAIAirAngelsB B CapitalFLFlare Capital PartnersINIndustry Ventures+3 more

Isaac Health provides virtual, interdisciplinary care for people experiencing memory and thinking changes, staffed by board-certified neurologists, geriatric specialists, neuropsychologists, speech-language pathologists, and care navigators.

Digital HealthHealthtechLongevity

JBJulius Bruch(Founder & CEO)inJSJoel Salinas(Founder)in

Co-investorsAUAurum Venture PartnersB B Capital GroupB4B4 CapitalFLFlare Capital PartnersMEMeridian Street CapitalVUVU Venture Partners+4 more

Political donor advising platform that directed over $37 million and 300,000 donations to 750+ candidates in 2024.

BDBrian Derrick(Founder)in

Co-investorsGAGaingelsHIHigher Ground LabsMCMcKesson VenturesRARackhouse Venture Capital

Optellum builds an AI-powered platform for early lung cancer diagnosis, helping thoracic care teams and health systems discover, track, and assess the malignancy risk of lung nodule patients.

AI & Machine LearningHealthtechMedical Devices

Co-investorsINIntuitive VenturesIQIQ CapitalMEMercia VenturesOUOutsized Ventures

Outpace Bio develops engineered protein technologies and cell therapies to treat solid tumors, focusing on protein design and T cell engineering to improve cancer treatment efficacy and safety.

BiotechDeep TechMedical DevicesSeattle, US

MLMarc Lajoie(Founder)inSBScott Boyken(Founder)inStanley Riddell(Co-Founder and Scientific Advisor)AFAaron Foster(Executive Officer)inCharity Scripture(Executive Officer)inESEric Soller(Executive Officer)in

Co-investorsARArtis VenturesRARA CapitalABAbstract VenturesATATEL VenturesATAtinum Investment Co. Ltd.CICivilization Ventures Management, Llc+9 more

Paragraf develops graphene-based electronic devices, including molecular sensors (electrolyte-gated field-effect transistors) for biosensing and chemical sensing, and Hall effect sensors for current, position, and magnetic field measurement at cryogenic temperatures.

Deep TechNew MaterialsSemiconductorsCambridgeshire, GB

STSimon Thomas(Chief Executive Officer of the issuer.)in

Co-investorsAMAmadeus Capital PartnersCACambridge Angels groupEMEMV CapitalINIn-Q-TelIQIQ CapitalMAMartlet Capital+5 more

Thesis Care provides clinical support services to healthcare organizations using technology to enable high-value work at scale, helping improve patient outcomes and experience.

AI & Machine LearningDigital HealthEnterprise SoftwareHealthtech

Niren Gandra, MD(CEO, Co-Founder)Aditya Pandyaram(CPO, Co-Founder)inNiren Gandra(CEO, Co-Founder)in

Co-investorsCRCRV (Charles River Ventures)OAOak HC/FT

TigerGraph provides a graph analytics platform designed to reveal relationships and connections across data that traditional analytics tools miss, supporting deep multi-hop queries.

AI & Machine LearningData & InfrastructureEnterprise SoftwareMilpitas, US

YXYu Xu(Founder)inLi Chen(Founder)Like Gao(Founder)Mingxi Wu(Founder)Ruoming Jin(Founder)

Co-investors1111.2 CapitalCECelesta CapitalDCDCVC (Data Collective)EAEastlink Capital PartnersMUMundi VenturesQIQiming Venture Partners+5 more