/Investor DB

Medical Excellence Capital — Full Portfolio

21 tracked investments · listed companies and verified rows first

ProJenXprojenx.comin𝕏Jan 2022 · $15M✓ verified

ProJenX is a clinical-stage biotechnology company developing novel, brain-penetrant therapies for neurodegenerative diseases, with an initial focus on amyotrophic lateral sclerosis (ALS).

BiotechDeep TechMedical DevicesNissequogue, US

Valerie Estess(Director)

BoardJohn Prufeta(Director)inJoni Mancini(Executive Officer)inBrent R. Stockwell(Chair of the Department of Biological Science, Professor at Columbia University)Hynek Wichterle(Jerry and Emily Spiegel Professor at Columbia University)

Board seatEric Heil· per SEC Form D

Co-investorsALS Investment Fund

Ladderbio (1)ladderbio.comin𝕏✓ verified

Ladder Bio (formerly ThirdLaw Molecular) develops Spiroligomer molecules, a class of synthetic, modular fused-ring compounds designed for highly selective binding to target proteins, along with computational design tools for targeted drug discovery.

BiotechDeep TechMedical DevicesBlue Bell, US

Christian Schafmeister(Founder)inEric Heil(Chief Executive Officer)in

Co-investorsHatch BioFundLong GameSmartGateVC

Pleno Inc.plenoinc.comin✓ verified

Pleno develops a genomic testing instrument platform designed to make multiomics testing faster, lower-cost, and higher-plex than existing methods like NGS, PCR, and microarrays.

BiotechHardwareHealthtech

Co-investorsForesite CapitalDeerfield Management Company

Thirdlawtxthirdlawtx.comin𝕏✓ verified

Ladder Bio (formerly ThirdLaw Molecular) develops Spiroligomer molecules, a class of synthetic, modular fused-ring compounds designed for highly selective binding to target proteins.

BiotechDeep TechMedical DevicesBlue Bell, US

Christian Schafmeister(Founder)Eric Heil(Chief Executive Officer)in

Co-investorsSmartGateVC

Aspen Neuroscienceaspenneuroscience.comin𝕏Nov 2025

Aspen Neuroscience develops iPSC-derived autologous cell therapies for neurological diseases, with a lead product (ANPD001) in Phase 1/2a clinical trials for Parkinson's disease.

BiotechDeep TechDigital HealthMedical DevicesSan Diego, US

Andrés Bratt-Leal(Co-Founder and Senior Vice President, Research & Development)inANDRÉS BRATT-LEAL, Ph.D.(Co-Founder; Senior Vice President, Research & Development)Damien McDevitt(President and Chief Executive Officer)inDAMIEN MCDEVITT, Ph.D.(President and Chief Executive Officer)

Co-investorsARCH Venture PartnersLifeforce CapitalOrbiMedDomain AssociatesEDB InvestmentsSection 32+10 more

Avilar Therapeuticsavilar-tx.comin𝕏

Avilar develops ATACs (ASGPR Targeting Chimeras), a class of protein degraders designed to target extracellular and membrane-bound proteins by harnessing the endolysosome's natural degradation process.

BiotechWaltham, US

THERESA CAMERON(Director)MARTIN FREED(Director)inSTEPHANIE TOZZO(Executive Officer)PHIL GRAHAM(Executive Officer)MILIND DESHPANDE(Director)DAVID NEAFUS(Executive Officer)

Co-investorsAstellas Venture Management LLCRA CapitalSanofi VenturesOpenSky Ventures

Clicbiotechclicbiotech.com

ClicBio develops oral small-molecule CLIC1 inhibitors to treat metabolic diseases by modulating appetite through hypothalamic neuron regulation.

BiotechDeep TechHealthtech

John Dobak(CEO and Co-Founder)Jay Hagan(Board Member and Co-Founder)Bruce Steel(Board Member and Co-Founder)Olivia Osborn(Co-Founder/Advisor)

GC Therapeuticsgc-tx.comin𝕏

GCTx develops an induced pluripotent stem cell (iPSC) programming platform called TFome™ that uses synthetic biology, gene editing, and machine learning to improve cell therapy development and scaling.

AI & Machine LearningBiotechMedical DevicesCambridge, US

George Church(Co-Founder & Scientific Advisor)Parastoo Khoshakhlagh(Chief Executive Officer & Co-Founder)inAlex Ng(Chief Innovation Officer & Co-Founder)in

Co-investorsAlumni VenturesAndreessen HorowitzGaingelsGlobal BrainHumboldt

Immunitas Therapeuticsimmunitastx.cominSeries B · Aug 2021 · $58M

Immunitas discovers and develops therapeutic antibodies for cancer and autoimmune diseases, with its lead program targeting CD161 for solid tumors and hematological malignancies.

BiotechDigital HealthMedical DevicesWaltham, US

Amanda Wagner(CEO)inDan Matloff(Executive Officer)Jiaping Gu(Director)Jeffrey Goldberg(Executive Officer, Director)

BoardLaura Brass(Director)inKai Wucherpfennig(Director)

Co-investorsAgent CapitalDC Investment PartnersLifelinkLongwood FundM VenturesNovartis Venture Fund+5 more

Nobiastxnobiastx.com

Nobias Therapeutics is a clinical-stage drug developer creating small-molecule therapeutics for genetically-defined rare diseases, initially focused on pediatric indications with potential expansion into adult and non-rare conditions.

AI & Machine LearningBiotechHealthtech

Hakon Hakonarson(Co-Founder and Chief Scientific Advisor)Brian Halak(Co-Founder)inPatrick Dougherty(Chief Executive Officer)Ryan McMillian(Consulting Chief Financial Officer)

SonoTherasonothera.comin𝕏Jun 2026

SonoThera is developing a nonviral, non-invasive gene delivery technology that uses ultrasound and microbubbles (ultrasound-mediated delivery) to deliver genetic payloads to targeted sites in a redosable way.

BiotechDeep TechDigital HealthHealthtechSouth San Francisco, US

Kenneth Greenberg(Co-Founder, President & CEO)in

Co-investorsVida VenturesLeaps by BayerARCH Venture PartnersFoothill VenturesIllumina VenturesVivo Capital+8 more

Trotana Therapeuticstrotana.com

San Diego biotech founded in 2019 developing oral anti-inflammatory small molecules targeting RNA binding proteins.

Co-investorsARCH Venture PartnersLightstone VenturesCanaan Partners

Truviantruvianhealth.comin𝕏

Truvian builds an on-site blood diagnostics platform that combines clinical chemistry, immunoassay, and hematology testing in a single compact instrument.

BiotechDigital HealthMedical DevicesSan Diego, US

Dena Marrinucci(Co-Founder & Chief Operating Officer)inMichael J. Mina(Chief Medical and Strategy Officer)in

Co-investorsDns CapitalGreatPoint VenturesWittington VenturesDomain AssociatesEmbark VenturesXB Ventures+1 more

TwoStep Therapeuticstwosteptx.comin

TwoStep Therapeutics is a Stanford spinout developing targeted cancer therapies, including peptide-based drug conjugates and radioligand programs built on a tumor-targeting peptide platform.

BiotechHealthtechSan Carlos, US

Caitlyn Miller(CEO & Co-Founder)inJennifer Cochran(Co-Founder)Carolyn Bertozzi(Co-Founder)Ronald Levy(Co-Founder)

BoardOmri Amirav-Drory(Director)inJohn Prufeta(Director)in

Co-investors2048 VenturesFifty YearsM VenturesNFX

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

Rejuvitas, Inc.ClicBioImmunitasLadder BioLadder Bio (formerly ThirdLaw Molecular)Nobias TherapeuticsThirdLaw Molecular

Rows marked “SEC filing” are inferred from directors named on the company's SEC Form D — public regulatory data, not a portfolio list published by the firm.