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Adaptive Waves develops smart coating technology, validated and advanced through NSF SBIR/STTR Phase I and Phase II grants.

CleantechDeep TechHardwareNew MaterialsSpace Tech

Agapé is a mobile app designed to strengthen romantic relationships through daily personalized questions that spark meaningful conversation between couples.

ConsumerHealthtechWellness & FitnessRochester, US

Kadie Okwudili(Founder)inRon Rogge(Founder)

Co-investorsY Combinator

Agri-Trak provides a cloud-based farm operations platform for small family farms to track labor, crop yield, and costs in real-time.

AgTechCloud ComputingData & InfrastructureSaaSWilliamson, US

Jamie Sonneville(Founder)in

Co-investorsTechstars

AireXpert provides a knowledge exchange and collaboration platform for the global aviation and aerospace technical community, connecting maintenance professionals, airline operators, and MRO companies to share expertise and best practices.

Enterprise SoftwareMobility & TransportationSaaS

Andy Hakes(Founder)in

Co-investorsReformation Partners

Anaghe Atelier makes made-to-order clothing and accessories, including designer sweatshirts, vintage printed and graphic tees, and Apple Watch bands, card cases, and key fobs crafted from upcycled luxury handbags.

Circular EconomyDirect to ConsumerE-commerceBuffalo, US

Arbol is a student financial success platform that helps higher education institutions improve enrollment, retention, and completion by guiding students through financial aid decisions and requirements.

EdTechFintechImpact & Social GoodSaaSBuffalo, US

Siddhartha Jha(Executive Officer, Director)Ben Andre(Executive Officer, Director)Osho Jha(Executive Officer)Philippe Heilberg(Executive Officer, Director)

Co-investorsBrass Ring VenturesTechstarsVC 414WNY Impact Investment Fund

Aurie designs a reusable intermittent catheter system intended to reduce infection risk and improve ease of use compared with single-use catheters.

HealthtechMedical DevicesWellness & FitnessNew York City, US

Souvik Paul(CEO)

Co-investorsDorm Room

AvantGuard, a Cornell University spin-out originally founded as Halomine, develops N-halamine-based antimicrobial and surface-protection technology aimed at combating pathogens including the fungus Candida (Candidozyma) auris.

BiotechHealthtechNew Materials

Edward S. Eveleth(CEO)Marc Hein(CTO)inMichael Newell(VP of Sales and Marketing)in

Aviate Audio makes Multiverse, a customizable digital effects pedal for musicians that runs a downloadable library of audio effects created by various developers and brands.

ConsumerHardware

Azuna makes air care products that use pure organic Australian tea tree oil in gel form to neutralize household odors for up to 90 days, without harsh chemicals or heavy perfumes.

Advanced ManufacturingConsumerDirect to ConsumerBuffalo, US

Scott Dancy(Executive Officer, Director)

Beauty Buzz is a mobile app that connects beauty shoppers with beauty professionals for real-time appointment booking, helping pros fill open spots and clients discover and book services.

ConsumerMarketplacesWellness & Fitness

BetterMynd is a teletherapy service providing online mental health counseling to college students through partnerships with campuses.

Digital HealthEdTechHealthtechMental Health

Cody Semrau(Founder)in

Co-investorsBread And Butter Ventures, LlcFigure 8 Investments

Big Daddy Garden Company sells gardening tools and equipment for homeowners, including its Big Daddy Garden Caddy, a multi-function yard cart with a built-in hose, sprayer, water storage, seating, and kneeling pad, along with spades, trowels, and gloves.

ConsumerDirect to ConsumerE-commerce

BraidBabes is a mobile hair-braiding service whose stylists travel to the customer's location to create custom braids, specializing in boho braids for events and weddings and offering braid and shimmer parties.

Consumer

BreeziPro provides predictive maintenance technology for commercial HVAC systems, using its AirPulse wireless IoT device and AirAssurance software to monitor air filter condition, equipment health, and indoor air quality.

CleantechIoTPropTechResearch Triangle Park, US

Bridge Green Upcycle develops proprietary technology for lithium-ion battery recycling, including battery health monitoring, second-life applications, and the extraction of black mass and precursor materials.

Circular EconomyCleantechEnergy

Balakrishnan G. Iyer(Founder & CEO)

CAHill TECH develops aQuiRe, a mobile app platform with safety and skills training videos for construction workers.

Construction TechEdTechHR TechSaaSAkron, US

Carley Hill(Founder & CEO)in

Co-investorsTechstarsWNY Impact Investment Fund

CaHill Resources is a certified WBE, DBE, and WOSB provider of site contracting services and equipment rental, with a focus on heavy highway and civil construction.

Construction Tech

Revora Materials operates a technology platform that recovers critical minerals such as magnesium, nickel, manganese, platinum group metals, and rare earth elements from industrial byproducts and ores, including mine tailings, slag, and cement-making residues.

Circular EconomyCleantechNew Materials

CareTech Human develops a remote urinalysis device (UroWell) using optical sensing, microchips, and cloud processing to let urologists monitor and assess patient condition without frequent office visits.

Digital HealthHealthtechMedical DevicesIthaca, US

Denys Matsui(Executive Officer, Director)Dr. Dan Matsui(Founder and CEO)inOleksandr Korobov(Chief Technical Officer)inJohn De Caro(Chief Medical Officer)inOlena Rapoport(Chief Clinical Research Officer)inIrina Belenkaya(Chief Operating Officer)in

Casana Care makes the Smart Seat, a toilet-mounted biometric monitoring device that tracks vital signs like heart rate, blood oxygen, and blood pressure trends for personal wellness tracking.

HardwareHealthtechIoTMedical DevicesWellness & FitnessRochester, US

Nick Connin

Co-investorsGeneral CatalystOutsidersMatrix

Circuit Clinical describes its team culture, employee benefits, and hiring, but the page provides no concrete detail about its products or services.

BiotechDigital HealthHealthtechBuffalo, US

Irfan Khan(Executive Officer, Director)inKerry R. Hicks(Director)Jackie Kent(Director)Craig Lipset(Director)Katherine Sullivan(Executive Officer)Kevin Christner(Executive Officer)

Co-investorsWNY Impact Investment Fund

Combined Energies develops proprietary power conversion products for OEM customers and end users in the energy storage, renewables, electric vehicle, and alternative energy markets.

CleantechEnergyHardwareRochester, US

John Vogel(Managing Member)Rhonda Staudt(Treasurer and Manager)Mark Sperry(President and Manager)

Cyrisma provides a unified cybersecurity platform combining attack surface, vulnerability, data, and compliance management, including asset discovery and patching, in a single multi-tenant tool.

Cloud ComputingCybersecurityEnterprise SoftwareSaaS

Co-investorsBlueprint EquityGolden Ventures

Dentite provides an AI-driven medical billing service for dental practices, automating the process of billing medical insurance for medically necessary and preventive dental procedures to generate additional revenue.

AI & Machine LearningFintechHealthtechBuffalo, US

Petar Tofovic(CEO & Co-founder)inXENIA RICHTER(Executive Officer, Director)inDANIEL RICHTER(Executive Officer, Director)JEROD SIKORSKYJ(Executive Officer, Director)in

Co-investorsStone Mountain Ventures

DiabeTech develops an AI-powered biosensor sock and mobile platform to detect diabetic foot complications and ulcers at an early stage, serving patients and healthcare providers.

AI & Machine LearningDigital HealthHealthtechMedical DevicesNew York, US

Tosin Alabi(Founder & CEO)in

Diadem operates a curated deal-flow platform that connects startups with funds, family offices, lenders, and angel investors through AI and human filtering.

AI & Machine LearningFintechSaaS

Dimensional Energy develops catalyst and service technology for producing sustainable fuels, licensed to project partners through a recurring, capital-light licensing model.

CleantechClimate TechEnergyNew MaterialsIthaca, US

Tobias Hanrath(Director)David Erickson(Director)inJason Salfi(Executive Officer, Director)inClayton Poppe(Executive Officer, Director)

Co-investorsBeni Venture CapitalChloe CapitalNew Climate VenturesDSC InvestmentEnvisioning PartnersGolden Gate Ventures+1 more

EagleHawk operates a facilities intelligence platform that combines aerial imaging, expert analysis, and data management tools to help organizations monitor building conditions and manage assets.

Construction TechEnergyPropTechBuffalo, US

Jonathan Byrd(Executive Officer, Director)inPatrick Walsh(Executive Officer, Director)inWillard Schulmeister(Executive Officer)

BoardJoseph Weiss(Director)

Co-investorsGENIUS NY

Eat Me makes plant-based, vegan-certified non-dairy ice cream with simple ingredients and rotating flavors, sold to consumers across Upstate New York and the East Coast.

ConsumerDirect to ConsumerFoodTechRochester, US

Ecolectro is an e-commerce site providing information on goods and services, with the ability for users to contact the company and sign up for a mailing list.

CleantechClimate TechE-commerceEnergyIthaca, US

Kristina M. Hugar(Executive Officer, Director)inGabriel G. Rodríguez-Calero(Founder)inZinovia Spezakis(Executive Officer)Jon Gordon(Executive Officer)

BoardRobert W. Shaw(Director)Lisa Coca(Director)in

Co-investorsNew Climate VenturesStarshotTechstarsAsymmetric Capital PartnersToyota Ventures

Edenesque makes chef-crafted plant-based dairy products, including oat milk and barista blend pistachio milk, sold direct-to-consumer.

ConsumerDirect to ConsumerFoodTechBuffalo, US

Leslie Woodward(Founder)in

Co-investorsRed Bear AngelsThe Veteran Fund

energyGuard Hub is a smart thermostat that lets users control their home heating remotely and is marketed as reducing average heating bills.

CleantechEnergyIoT

Co-investorsCambium CapitalCandou VenturesCelesta CapitalCelesta CapitalEastlink Capital PartnersOUP (Osage University Partners)+2 more

Farther Farms develops technology to make shelf-stable versions of traditionally frozen or refrigerated foods, allowing distribution without cold-chain infrastructure.

Deep TechFoodTech

Vipul Saran(Co-founder & Chief Technology Officer)in

Co-investorsDorm RoomSiddhi Capital

Feeloh is a consumer app that acts as a personal social assistant to help adults plan and organize activities and shared experiences with friends, such as restaurant visits, classes, and hikes.

ConsumerSocial

Alexia(Founder)

Ferric Contrast develops iron-based MRI contrast agents intended to produce high-quality magnetic resonance images of the brain, vasculature, liver, kidneys, and cancer-related tumors.

BiotechHealthtechMedical Devices

For Bitter For Worse makes non-alcoholic cocktails using certified organic botanicals, offered directly to consumers including via a subscription option.

ConsumerDirect to ConsumerFoodTech

Fret Zealot, operated by Zealot Interactive Inc., develops software and hardware products for music education.

AI & Machine LearningConsumerEdTechHardware

GCLIProw makes GCLIP Drive, a rowing shoe-clip system that clips in and out of footboards and erg machines for use on the water or at the gym.

Advanced ManufacturingCircular EconomyHardwareSports TechBuffalo, US

Co-investorsBrown and White Ventures

The page presents BIRUTOTO, an Indonesian-language online slot gambling platform offering various popular slot games (such as Gates of Olympus and Mahjong Ways 2) with integrated account transactions and customer support.

Gaming

Co-investorsRed Bear AngelsCircleUpRand Capital

Heat Inverse develops cooling technology aimed at reducing emissions, drawing on expertise in mid-infrared photonics and metamaterials.

CleantechClimate TechDeep TechNew Materials

Romy Fain(Chief Executive Officer, Founder)inFrancesco Monticone(Chief Science Officer)

HelixIntel offers HelixCMMS, a computerized maintenance management platform for maintenance and facilities teams to run work orders, preventive maintenance, and asset tracking, and HelixPrevent, a risk-prevention suite for insurance carriers, pools, and programs.

InsurTechPropTechSaaSBuffalo, US

Jonathan DeWald(Executive Officer, Director)Michael Mainier(Executive Officer, Director)inMatt Rutter(Executive Officer)inBrian Sullivan(Executive Officer)inEmily Mainier(Executive Officer)in

BoardPradeep Tagare(Director)

Co-investorsGreen Egg VenturesLAB VenturesStellifiMotivate Venture CapitalMOTIVATE VENTURESMunich Re Ventures+1 more

Huey Suncare makes daily SPF 30 sunscreen lotion offered in five shades based on the Fitzpatrick skin typing scale, designed to provide sun protection across different skin tones.

ConsumerDirect to ConsumerWellness & Fitness

Justin(Founder)

Intelli-Fun makes interactive learning games designed for early childhood and elementary education, with content developed alongside educators to cover STEM subjects.

ConsumerEdTechGaming

JECA makes gluten-free nutrition and snack bars formulated with healthy fats, fiber, protein, and antioxidants, free of refined sugar, soy, dairy, and oils.

Direct to ConsumerFoodTechWellness & Fitness

Ree Dolnick(Founder)

Kool Nerd Connect provides career education programs and coursework designed to prepare diverse students for in-demand jobs in high-growth industries, including healthcare and technical fields.

EdTechFuture of WorkHR Tech

Orane Barret(Founder, CEO)

LayerMetrics develops opto-photonic sensing and metrology technology for real-time optical measurement and process control.

Advanced ManufacturingDeep TechHardware

Clare(Owner & Co-Founder, CEO)inDom(Co-Founder & CTO)in

Co-investorsThe Innovation Space

Melanin Skyn Co. is a skincare brand offering products formulated for sensitive and eczema-prone skin across all melanin tones, along with hair care items.

ConsumerDirect to ConsumerWellness & Fitness

Ashley V. Nicole(Founder)

MemoryFox is a storytelling platform that helps mission-driven organizations capture and share community-generated content and personal stories.

Impact & Social GoodMarketing TechSaaSKenmore, US

Chris Miano(Founder and CEO)inJacob Balon(Director)

NavigateMD operates a platform that connects people with disabilities and their families to medical providers, businesses, non-profit organizations, and other resources matched to their needs.

Digital HealthHealthtechMarketplaces

Co-investorsRockstart

Noshi sells natural-colored and natural-flavored frosting sets for children, marketed as a way to address picky eating.

ConsumerDirect to ConsumerFoodTech

Off Duty Blue is a cloud-based scheduling platform for law enforcement agencies to manage overtime and off-duty detail assignments, coordinating coordinators, officers, department leadership, and security clients.

GovTechSaaS

Ognomy Sleep is a virtual platform providing end-to-end sleep apnea diagnosis and treatment through licensed sleep medicine specialists.

Digital HealthHealthtechSaaSBuffalo, US

Daniel Rifkin(Founder & CEO)Greg Ross(Founder)inJune Seliber-Klein(Executive Officer)inPeter Grandits Jr.(Executive Officer, Director)inKen Rosenfeld(Executive Officer)in

BoardDavid Brown(Director)in

Co-investorsCatalyst InvestorsBlue Heron CapitalExcell PartnersImpellent Ventures

P1ston offers AI-powered SaaS for managing inbound supply chains, tracking open purchase orders and automating PO acknowledgements, ASNs, supplier spreadsheets, and RFQs.

AI & Machine LearningLogistics & Supply ChainSaaS

Panacheeza makes a dairy-free, plant-based grated parmesan cheese alternative made from five ingredients (organic cashews, nutritional yeast, garlic powder, Himalayan pink sea salt, and apple cider vinegar), sold in Original, Truffle, and Hot & Spicy varieties.

ConsumerDirect to ConsumerFoodTech

Janessa Steenberg(Founder)in

Paradigm designs and manufactures pollution control devices for diesel and gasoline engines that reduce emissions and particulate matter while lowering maintenance costs and fuel consumption.

Advanced ManufacturingCleantechClimate TechEnergyHardwareRochester, US

John H. Erbland(Founder and CEO)Mike Tschiderer(Executive Officer)

BoardWilliam Carpenter(Director)Robert Poltrino(Director)

Co-investorsBrown and White Ventures

Persistent Courage offers coaching and consulting for individuals, organizations, and non-profits, focusing on strategy, leadership, brand, marketing, and operations.

Enterprise SoftwareFuture of Work

Sondra Imperati

Co-investorsAmboy Street VenturesFourward VenturesPalm Tree Crew Investments

ZIZO is a performance management platform that uses gamification, real-time recognition, and automated coaching to improve productivity, retention, and engagement.

Future of WorkGamingHR TechSaaS

Jimmy Chebat(CEO & Founder)inJill Fecher(Sales & Marketing)inNadiia Ivarova(Head of Product)inDmytro Makivskiy(Head of Development)in

PostProcess Technologies develops automated post-processing solutions for additive manufacturing, helping manufacturers remove support material and finish 3D-printed parts at scale.

Advanced ManufacturingHardwareRoboticsBuffalo, US

Daniel Hutchinson(Executive Officer, Director)inJeff Mize(CEO)inDean VonBank(Chief Experience Officer)in

BoardDan DiPofi(Director)Charles E. Lannon(Director)Sam Heleba(Director)

Co-investorsMotley Fool Ventures

KHIO is a wearable device that applies targeted, drug-free cooling therapy to the forehead to relieve migraines, headaches, muscle tension, and post-workout heat.

HardwareHealthtechWellness & Fitness

Relatability provides dating and relationship coaching, resources, and training for people with disabilities, along with programs for the professionals who support them.

Impact & Social GoodMental HealthWellness & Fitness

Kathy O'Connell(Founder)

Re-Nuble makes circular growing inputs for indoor agriculture, including ReNu Terra hydroponic grow mats and Away We Grow organic liquid nutrients derived from vegetative waste.

AgTechCircular EconomyNew Materials

Co-investorsThe BFM FundWocstar Capital

sayhii is a real-time employee feedback and insight platform that collects daily micro-signals from workers and turns them into actionable insights for leaders at the individual, team, and organizational level.

Future of WorkHR TechSaaS

SelectFI provides an AI-based tool for car dealerships that predicts loan approval and interest rates for each deal without submitting formal credit applications or requiring a customer's SSN.

AI & Machine LearningFintechSaaSWilliamsville, US

Tommy Vullo(Executive Officer, Director)Matthew Dorn(Executive Officer, Director)Andrew Dorn, IV(Executive Officer, Director)

Co-investorsAutomotive Ventures Mobility

Refraction builds software to help car dealers adapt to market changes and improve the car-buying experience for consumers.

AI & Machine LearningRetail TechSaaS

Sign-Speak uses AI to translate communication into sign language, making information and content accessible to deaf and hard of hearing communities globally.

AI & Machine LearningDigital HealthSocialVictor, US

NikoNicholas Wilkins(Machine Learning Expert)inYamillet Payano(Co-founder)Nikolas Kelly(Executive Officer, Director)

Co-investorsTechstarsVisible HandsBoston Impact Initiative (BII)

SpeechLink offers Speech Motor Chaining, a tool that generates evidence-based speech sound therapy practice sessions for speech-language pathologists and their clients.

AI & Machine LearningDigital HealthHealthtech

Spotlight Creators operates a platform for visual and creative artists to share their work, connect with a supportive community, and build sustainable creative careers.

ConsumerCreator EconomyMarketplacesSaaSSocial

Angel Yang(Co-founder)

Start Smart Plus offers senior care planning that combines care managers, smart home technology, and a family portal to help families keep aging loved ones living independently at home.

Digital HealthHealthtechWellness & Fitness

Shonda Brock(Founder)

TeleSafety provides on-demand workplace safety guidance, training, and compliance support for construction and manufacturing companies, combining certified safety professionals with AI tools.

AI & Machine LearningConstruction TechSaaS

Dr. John P. Coniglio(Co-founder)Joseph Coniglio(Co-founder)inJake Coniglio(Co-founder)

Telosair provides indoor air quality monitoring and optimization solutions, partnering with HVAC and building automation experts, resellers, and installers.

CleantechHardwareHealthtechIoTPotsdam, US

Dr. Suresh Dhaniyala(CTO/President)

BoardMark Sperry(Board Member)

The Giving Hub is an online donation platform that lets people give cash or goods to nonprofits, and provides nonprofits with tools to meet needs and connect with supporters.

Impact & Social GoodMarketplaces

Verivend is a payments platform built for private capital markets, enabling general partners and investment sponsors to send capital calls and distributions to investors and manage funds electronically.

Enterprise SoftwareFintechSaaS

Co-investorsBand of Angels

Santaia (formerly VISUALIZEin360) is a neuroscience-based wellness platform that maps brain, body, and lifestyle patterns from home and offers structured weekly modules to help individuals retrain how they think, feel, and function.

Digital HealthMental HealthWellness & Fitness

VPG Medical provides telehealth services that connect patients with licensed healthcare professionals for remote consultations and ongoing care.

Digital HealthHealthtechRochester, US

Gill Tsouri(Executive Officer, Director)Jean-Philippe Couderc(Executive Officer, Director)Alexander Zapesochny(Director)

Walkabout Collaborative LLC operates a networked community connecting on-demand, outcome-based consultants with mid-size business clients seeking cost-effective business transformation services.

B2B MarketplacesEnterprise SoftwareFuture of WorkMarketplacesAngola, US

Antoinette Forth(Co-Founder)inToni Portmann(Executive Officer)

Z-Loupes develops ergonomic dental loupes with features such as lighter weight, neck-mounted batteries, and handsfree controls for infection control.

HardwareHealthtechMedical Devices

Zina Berry(Founder)in