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Crucible develops RNA-based therapies targeting neurodegenerative diseases, leveraging research from the University of Sheffield's translational neuroscience institutes.

BiotechDeep TechHealthtechSheffield, GB

Cliff Holloway(Chief Executive Officer)in

adsilico builds generative AI technology that creates diverse virtual patient populations—digital models of human anatomy, physiology, and pathology—to run in silico trials that assess medical device safety and performance before human testing.

AI & Machine LearningHealthtechMedical Devices

Dr Nishant RavikumarinDr Zeike TaylorinProf Alejandro FrangiSheena Macphersonin

Co-investorsParkwalk Advisors

AmpliSi develops porous silicon battery anode material using a proprietary silane-free, low-temperature magnesiothermic process that converts silica into high-energy silicon anodes to replace graphite in lithium-ion batteries.

CleantechEnergyNew Materials

Ruth Sayers(CEO)in

Co-investorsClean Growth Fund

Developer of a novel small molecule for treating chronic inflammatory diseases including Crohn's disease and Ulcerative Colitis.

AssetCool builds robotic systems, including its Capacity-1 line robots, that apply capacity-enhancing coatings to existing overhead power lines to increase grid capacity without lengthy outages or reconductoring.

CleantechEnergyNew MaterialsRobotics

Jasmin Stewart(Head of People)inWinter Wilson(Head of Marketing)inNiall Coogan(CEO)in

Co-investorsCarbonEnergy Impact PartnersKero Development PartnersMercia VenturesExtantia Capital

Auxetec develops patented liquid crystal elastomers with auxetic properties that resist impact, aimed at improving the durability and longevity of products in demanding applications.

Advanced ManufacturingDeep TechNew Materials

OLO Robotics builds products designed to simplify robotics development, aiming to make robotics accessible to users regardless of their level of expertise.

Developer ToolsEnterprise SoftwareRoboticsSaaSSheffield, GB

Co-investorsSyndicateRoom

Proprietary technology enabling high-level, localised gene expression to overcome crop engineering challenges.

Cytotrait develops genetic technologies for crop improvement through chloroplast engineering.

AgTechBiotechManchester, GB

Junwei Ji(Co-Founder & Executive Director)inAnil Day(Co-founder & Scientific Advisor)Tim Brears(Executive Chair)in

Co-investorsUK Innovation & Science Seed Fund

Exciting Instruments builds the EI-FLEX benchtop platform, a single-molecule fluorescence instrument combining smFRET, FCS and FCCS to measure biomolecular interactions and dynamics directly in solution.

BiotechDeep TechHardware

Timothy Craggs(Founder and CEO)

Floreon develops a patented bioplastic material designed to reduce carbon footprint and replace traditional oil-based plastics in manufacturing processes.

Circular EconomyCleantechNew MaterialsSheffield, GB

Shaun Chatterton(Founder and Chairman)in

Iceotope develops precision liquid cooling technology for data centers, AI infrastructure, and edge computing systems.

AI & Machine LearningCleantechDeep TechHardwareSheffield, GB

Co-investorsAster CapitalOmbu GroupSalica Investments

Co-investorsIQ Capital

Literal Labs develops logic-driven AI technology, positioning its work as an alternative approach to machine learning.

AI & Machine LearningDeep TechIoT

Noel HurleyinLeon FeddeninProfessor Alex YakovlevProfessor Rishad Shafik

Co-investorsGMG VenturesMercuri.vcSure Valley Ventures

MicroLub is a UK-based deep-tech ingredient company that develops protein-based biolubricant molecules — protein microgels coated with polysaccharides — that reduce molecular friction to replace fats and oils in food and personal care products while retaining their mouthfeel and texture.

BiotechDeep TechFoodTechLeeds, GB

Anwesha Sarkar(Founder)in

Co-investorsLIFTTPraetura Ventures

MicroLub is a deep-tech ingredient company that develops protein-based biolubricant molecules which reduce molecular friction to replace fats and oils in food and personal care products while retaining fat-like mouthfeel and texture.

Deep TechFoodTechNew MaterialsLeeds, GB

Mimetrik is a dental technology spinout from the University of Leeds founded by practicing dentists, developing digital solutions for the clinical dental pathway.

Deep TechHardwareHealthtechMedical DevicesLeeds, GB

Previously BOW; offers a software platform that handles robotics complexity so developers can focus on innovation.

Optalysys is a photonic computing company using silicon photonics to turn the optical layer into an arithmetic engine for high-performance computing.

Deep TechHardwareSemiconductorsLeeds, GB

Co-investorsAnglia Capital GroupVerve Venturesimec.xpand

Opteran develops autonomy software for robots and machines by reverse-engineering neural algorithms from insect brains, using computational neuroscience rather than deep learning.

AI & Machine LearningDeep TechRoboticsLondon, GB

James Marshall(Founder & Science Officer)Alex Cope(Co-founder & CTO)inDavid Rajan(CEO & Co-founder)

Co-investorsEpisode1IQ Capital

Partful builds a 3D interactive parts catalog platform that gives equipment operators and aftermarket end-users a real-time, immersive view of parts and repair instructions connected to the manufacturer.

Advanced ManufacturingEnterprise SoftwareLogistics & Supply ChainSaaS

Pencil Biosciences develops a fully synthetic, modular, non-CRISPR gene editing platform that edits DNA without causing a break or nick.

BiotechDeep TechHealthtech

Co-investorsEMV CapitalFuture Planet CapitalMartlet CapitalOctopus VenturesUK Innovation & Science Seed Fund

Phagenesis develops targeted pharyngeal electrical stimulation technology to treat neurogenic dysphagia by restoring neural pathways for safe swallowing.

Deep TechDigital HealthHealthtechMedical Devices

Co-investorsAphelion CapitalInnvotec Ltd.EQT Life SciencesSectoral Asset Management

Developing high-performance infrared sensors to improve laser rangefinder, LIDAR, fibre sensing and imaging systems.

Phlux Technology develops Noiseless InGaAs avalanche photodiode (APD) infrared sensors operating at 1550 nm that serve as drop-in replacements for traditional APDs.

Deep TechHardwareSemiconductors

Ben White(CEO)in

Co-investorsOctopus Ventures

PhovIR develops handheld near-infrared (NIR) spectroscopy technology based on a MEMS-enabled Michelson interferometer, packaging FTIR-grade material analysis into a small, low-cost, mass-manufacturable device.

Deep TechHardwareNew MaterialsManchester, GB

Tim Echtermeyer(Founder)in

Conveyor belt technology to reduce cross-contamination risks in the food industry.

Co-investorsDeepbridge Capital

Pragmatic is a European semiconductor company developing clean chips designed to reduce carbon emissions and waste compared to silicon alternatives.

CleantechDeep TechHardwareSemiconductorsCambridge, GB

Scott WhiteinRichard Pricein

Co-investorsIn-Q-TelProsperity7 VenturesARMBritish Patient CapitalCambridge Innovation CapitalCatalyst+4 more

Developer of an implanted electrotherapy device for treating brain cancer by targeting dividing cancer cells.

Co-investorsElbow Beach Capital

QV Bioelectronics develops GRACE, an implantable electric field delivery platform designed to treat aggressive cancers by delivering continuous therapeutic electric fields directly to tumor sites.

BiotechDeep TechHealthtechMedical Devices

Dr Chris Bullock(CTO & Co-Founder)Dr Richard Fu(Clinical Director & Co-Founder)

Deeptech company developing an AI healthcare training simulator for realistic patient interaction training.

Re:course develops natural language processing technology to enable machines to understand and communicate with humans in healthcare settings.

AI & Machine LearningDigital HealthEdTechEnterprise SoftwareHealthtechSaaS

Developing a highly sensitive material with direct conversion detectors to make X-ray equipment more efficient.

Silveray develops flexible X-ray detectors using patented semiconductor ink technology for non-destructive testing in industrial applications including oil and gas, nuclear energy, aerospace, and shipbuilding.

Advanced ManufacturingDeep TechHardwareStockport, GB

Co-investorsCambridge Angels groupFuture Planet CapitalUK Innovation & Science Seed Fund

Locus is a place-based analysis platform that integrates climate risk assessment, regional decarbonization planning, energy network analysis, and spatial planning tools for local authorities, utilities, and developers.

AI & Machine LearningCleantechClimate TechData & InfrastructureEnergyEnterprise SoftwareGovTechPropTech

Rob(CEO)

Sitehop provides encryption technology designed for real-time data protection that prioritizes speed and quantum-readiness.

CybersecurityDeep TechEnterprise SoftwareHardwareQuantum Computing

Melissa Chambers(Co-Founder and CEO)inBen Harper(Co-Founder and CTO)in

The University of Manchester's technology transfer office that commercializes academic research and intellectual property through spinout creation and licensing arrangements.

Deep TechEnterprise SoftwareImpact & Social GoodManchester, GB