Northern Gritstone — Full Portfolio

Crucible develops RNA-based therapies targeting neurodegenerative diseases, leveraging research from the University of Sheffield's translational neuroscience institutes.

BiotechDeep TechHealthtechSheffield, GB

CHCliff Holloway(Chief Executive Officer)in

adsilico builds generative AI technology that creates diverse virtual patient populations—digital models of human anatomy, physiology, and pathology—to run in silico trials that assess medical device safety and performance before human testing.

AI & Machine LearningHealthtechMedical Devices

DNDr Nishant RavikumarinDZDr Zeike TaylorinPAProf Alejandro FrangiSMSheena Macphersonin

Co-investorsPAParkwalk Advisors

AmpliSi develops porous silicon battery anode material using a proprietary silane-free, low-temperature magnesiothermic process that converts silica into high-energy silicon anodes to replace graphite in lithium-ion batteries.

CleantechEnergyNew Materials

RSRuth Sayers(CEO)in

Co-investorsCLClean Growth Fund

AssetCool builds robotic systems, including its Capacity-1 line robots, that apply capacity-enhancing coatings to existing overhead power lines to increase grid capacity without lengthy outages or reconductoring.

CleantechEnergyNew MaterialsRobotics

Jasmin Stewart(Head of People)inWWWinter Wilson(Head of Marketing)inNiall Coogan(CEO)in

Co-investorsCACarbonELElewitENEnergy Impact PartnersKEKero Development PartnersMEMercia VenturesEXExtantia Capital

Auxetec develops patented liquid crystal elastomers with auxetic properties that resist impact, aimed at improving the durability and longevity of products in demanding applications.

Advanced ManufacturingDeep TechNew Materials

OLO Robotics builds products designed to simplify robotics development, aiming to make robotics accessible to users regardless of their level of expertise.

Developer ToolsEnterprise SoftwareRoboticsSaaSSheffield, GB

Co-investorsSYSyndicateRoom

Cytotrait develops genetic technologies for crop improvement through chloroplast engineering.

AgTechBiotechManchester, GB

Junwei Ji(Co-Founder & Executive Director)inAnil Day(Co-founder & Scientific Advisor)TBTim Brears(Executive Chair)in

Co-investorsUKUK Innovation & Science Seed Fund

Exciting Instruments builds the EI-FLEX benchtop platform, a single-molecule fluorescence instrument combining smFRET, FCS and FCCS to measure biomolecular interactions and dynamics directly in solution.

BiotechDeep TechHardware

Timothy Craggs(Founder and CEO)

Co-investorsCACambridge Innovation CapitalEMEmpirical VenturesPRPraetura Ventures

Floreon develops a patented bioplastic material designed to reduce carbon footprint and replace traditional oil-based plastics in manufacturing processes.

Circular EconomyCleantechNew MaterialsSheffield, GB

SCShaun Chatterton(Founder and Chairman)in

Iceotope develops precision liquid cooling technology for data centers, AI infrastructure, and edge computing systems.

AI & Machine LearningCleantechDeep TechHardwareSheffield, GB

Co-investorsASAster CapitalOMOmbu GroupSASalica Investments

Literal Labs develops logic-driven AI technology, positioning its work as an alternative approach to machine learning.

AI & Machine LearningDeep TechIoT

NHNoel HurleyinLFLeon FeddeninPAProfessor Alex YakovlevPRProfessor Rishad Shafik

Co-investorsGMGMG VenturesMEMercuri.vcSUSure Valley Ventures

MicroLub is a UK-based deep-tech ingredient company that develops protein-based biolubricant molecules — protein microgels coated with polysaccharides — that reduce molecular friction to replace fats and oils in food and personal care products while retaining their mouthfeel and texture.

BiotechDeep TechFoodTechNew MaterialsLeeds, GB

ASAnwesha Sarkar(Founder)in

Co-investorsLILIFTTPRPraetura Ventures

Mimetrik is a dental technology spinout from the University of Leeds founded by practicing dentists, developing digital solutions for the clinical dental pathway.

Deep TechHardwareHealthtechMedical DevicesLeeds, GB

Optalysys is a photonic computing company using silicon photonics to turn the optical layer into an arithmetic engine for high-performance computing.

Deep TechHardwareSemiconductorsLeeds, GB

Co-investorsANAnglia Capital GroupIMimec.xpandVEVerve Ventures

Opteran develops autonomy software for robots and machines by reverse-engineering neural algorithms from insect brains, using computational neuroscience rather than deep learning.

AI & Machine LearningDeep TechRoboticsLondon, GB

JMJames Marshall(Founder & Science Officer)ACAlex Cope(Co-founder & CTO)inDavid Rajan(CEO & Co-founder)

Co-investorsEPEpisode1IQIQ CapitalSESeraphim Space

Partful builds a 3D interactive parts catalog platform that gives equipment operators and aftermarket end-users a real-time, immersive view of parts and repair instructions connected to the manufacturer.

Advanced ManufacturingEnterprise SoftwareLogistics & Supply ChainSaaS

Co-investorsBLBlumberg Capital

Pencil is an AI operating system for marketing that aggregates multiple AI models (from OpenAI, Google, Adobe, Runway, and Bria) into one orchestration layer with enterprise governance controls.

AI & Machine LearningEnterprise SoftwareMarketing TechSingapore, SG

WHWill Hanschell(CEO)inSASumukh Avadhani(CTO)in

Co-investorsBRBrandtech VenturesENEntrepreneur FirstWAWavemaker PartnersARArtesianCACatapult VenturesMAMartlet Capital+6 more

Pencil Biosciences develops a fully synthetic, modular, non-CRISPR gene editing platform that edits DNA without causing a break or nick.

BiotechDeep TechHealthtech

Co-investorsEMEMV CapitalFUFuture Planet CapitalMAMartlet CapitalOCOctopus VenturesUKUK Innovation & Science Seed Fund

Phagenesis develops targeted pharyngeal electrical stimulation technology to treat neurogenic dysphagia by restoring neural pathways for safe swallowing.

Deep TechDigital HealthHealthtechMedical Devices

Co-investorsAPAphelion CapitalINInnvotec Ltd.EQEQT Life SciencesSESectoral Asset Management

Phlux Technology develops Noiseless InGaAs avalanche photodiode (APD) infrared sensors operating at 1550 nm that serve as drop-in replacements for traditional APDs.

Deep TechHardwareSemiconductors

BWBen White(CEO)in

Co-investorsBUBusiness Growth FundOCOctopus Ventures

PhovIR develops handheld near-infrared (NIR) spectroscopy technology based on a MEMS-enabled Michelson interferometer, packaging FTIR-grade material analysis into a small, low-cost, mass-manufacturable device.

Deep TechHardwareNew MaterialsManchester, GB

Tim Echtermeyer(Founder)in

A crypto platform gamifying the casino experience with blockchain technology.

Co-investorsHAHack VCHTHTGFSCSCVC LP

Conveyor belt technology to reduce cross-contamination risks in the food industry.

Co-investorsDEDeepbridge Capital

Pragmatic is a European semiconductor company developing clean chips designed to reduce carbon emissions and waste compared to silicon alternatives.

CleantechDeep TechHardwareSemiconductorsCambridge, GB

SWScott WhiteinRPRichard Pricein

Co-investorsCACambridge Innovation CapitalINIn-Q-TelPRProsperity7 VenturesARARMBRBritish Patient CapitalCACatalyst+4 more

QV Bioelectronics develops GRACE, an implantable electric field delivery platform designed to treat aggressive cancers by delivering continuous therapeutic electric fields directly to tumor sites.

BiotechDeep TechHealthtechMedical Devices

Dr Chris Bullock(CTO & Co-Founder)Dr Richard Fu(Clinical Director & Co-Founder)

Co-investorsELElbow Beach CapitalCACatapult VenturesEMEmpirical VenturesSCScience Angel SyndicateSOSOSV

Re:course develops natural language processing technology to enable machines to understand and communicate with humans in healthcare settings.

AI & Machine LearningDigital HealthEdTechEnterprise SoftwareHealthtechSaaS

Co-investorsONOnstage

Silveray develops flexible X-ray detectors using patented semiconductor ink technology for non-destructive testing in industrial applications including oil and gas, nuclear energy, aerospace, and shipbuilding.

Advanced ManufacturingDeep TechHardwareStockport, GB

Co-investorsCACambridge Angels groupFUFuture Planet CapitalUKUK Innovation & Science Seed FundACACF Investors

Locus is a place-based analysis platform that integrates climate risk assessment, regional decarbonization planning, energy network analysis, and spatial planning tools for local authorities, utilities, and developers.

AI & Machine LearningCleantechClimate TechData & InfrastructureEnergyEnterprise SoftwareGovTechPropTech

Rob(CEO)

Sitehop provides encryption technology designed for real-time data protection that prioritizes speed and quantum-readiness.

CybersecurityDeep TechEnterprise SoftwareHardwareQuantum Computing

MCMelissa Chambers(Co-Founder and CEO)inBHBen Harper(Co-Founder and CTO)in

Co-investorsAMAmadeus Capital PartnersMAManta Ray VenturesOSOsney CapitalMEMercia Ventures

The University of Manchester's technology transfer office that commercializes academic research and intellectual property through spinout creation and licensing arrangements.

Deep TechEnterprise SoftwareImpact & Social GoodManchester, GB