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Aperture Therapeutics uses machine learning to mine genomic and clinical datasets for naturally occurring protective gene variants, then designs oligonucleotide therapeutics that mimic those variants to treat neurodegenerative diseases such as ALS and FTD and delay brain aging.

AI & Machine LearningBiotechLongevity

MJMartin Jacko(Founder & CEO)in

Co-investorsAGage1XEXEIA Venture Partners

Cirrus Therapeutics is a biotech developing gene and cell therapies based on ocular immunology to treat dry age-related macular degeneration (AMD), including an AAV gene therapy to restore the IRAK-M immune regulator and a next-generation retinal pigment epithelium (RPE) cell therapy for advanced geographic atrophy.

BiotechHealthtechLongevityCambridge, US

YKYing Kai Chan(Co-founder & CEO)inAndrew Dick(Director, Promoter)

BoardACAlexandra Cantley(Director)inKhoo Shih(Director)

Co-investorsCLClavystBioZAZAKA VCPOPolaris Partners

Deciduous Therapeutics develops small molecule and immunomodulatory therapies targeting senescent cells to treat age-related diseases including Type 1 diabetes, autoimmunity, and metabolic disorders.

BiotechDigital HealthLongevitySan Francisco, US

RMRobin Mansukhani(CEO and Co-Founder)inABAnil Bhushan(Scientific Founder)in

BoardDMDylan Morris(Director)in

Co-investorsAGage1BOBold Capital PartnersCOCornucopian Capital ManagementCRCRV (Charles River Ventures)GAGaingelsLILifespan Vision Ventures+4 more

Enhanced develops a scientific platform that combines sports performance analysis with human potential optimization.

AI & Machine LearningConsumerDigital HealthHealthtechSports TechWellness & Fitness

MMMaximilian Martin(Co-Founder & CEO)inChristian Angermayer(Co-Founder & Executive Chairman)DADr Aron D'Souza(Founder)

Co-investorsBIBig Brain HoldingsDCDCVC (Data Collective)DEDecisive PointFLFlowdeskGSGSRINInitialized Capital+3 more

General Proximity develops proximity-based technologies for drug discovery and development.

AI & Machine LearningBiotechDeep TechHealthtechSan Francisco, US

ACArmand Cognetta(Founder)inMatthias PauthnerCorentine Laurin(Principal Scientist, Medicinal Chemistry)Veronica Fulton(Chief of Staff)Benji Dote(EA)Reen Ramos(EA)

Co-investorsY Y CombinatorAGage1FEFelicis VenturesFRFreemind InvestmentsLILifespan Vision VenturesMAMana Ventures+4 more

HeraSight develops genetic tests for families, including preimplantation embryo screening that uses polygenic risk scores and carrier screening to predict risks for conditions such as Alzheimer's, schizophrenia, cancers, autism, and diabetes.

BiotechDigital HealthHealthtech

Co-investorsDRDraper AssociatesNZNZVC

ImmuneBridge is a company working in cell-based cancer immunotherapy, including research on engineered natural killer cells for solid tumor treatment.

AI & Machine LearningBiotechDeep TechHealthtechMedical DevicesSan Francisco, US

Peretz Partensky(Executive Officer, Director)inSAStuart Alexander Jacobson(Executive Officer, Director)NHNina Horowitz(Chief Executive Officer)inRTRui Tostoes(Chief Technology Officer)inAJAlicia Jackson(Director)in

BoardDMDylan Morris(Director)in

Co-investorsGAGaingelsM M VenturesNFNFXPIPioneerHEHealthspan CapitalINInsight Partners+2 more

Ladder Bio (formerly ThirdLaw Molecular) develops Spiroligomer molecules, a class of synthetic, modular fused-ring compounds designed for highly selective binding to target proteins, along with computational design tools for targeted drug discovery.

BiotechDeep TechMedical DevicesBlue Bell, US

CSChristian Schafmeister(Founder)inEHEric Heil(Chief Executive Officer)in

Co-investorsMEMedical Excellence CapitalHAHatch BioFundSMSmartGateVC

Lucis provides personalized health monitoring and guidance by combining laboratory biomarker testing with educational insights and actionable recommendations.

AI & Machine LearningDigital HealthHealthtechWellness & FitnessParis, FR

MBMax Berthelot(CEO)inBDBaptiste Debever(CTO)inJDJulien Do Vale(M.D., MSc, Chief Medical Officer)inMax Guerois

BoardAAAntoine Andremont(M.D., PHD, President of the scientific board)JBJérémy Bos(MD, MSc, Specialist in public health and clinical epidemiology)

Co-investorsCICircle & Co.CLCloverGEGeneral CatalystKIKima VenturesMOMotier VenturesNONorth South Ventures+7 more

Morris Laster, MD(Founder)in

Co-investorsSOSOSV

Notion offers a workspace platform for teams to manage projects, documentation, and tasks through customizable views like Gantt charts and Kanban boards.

AI & Machine LearningEnterprise SoftwareFuture of WorkSaaSSan Francisco, US

IZIvan Zhao(Founder)inAkshay Kothari(Founder)Simon Last(Founder)in

Co-investorsA.A.Capital VenturesA*A*BABase10 PartnersCOCoatue ManagementCRCraft VenturesDEDesigner Fund+34 more

Oisín Biotechnologies develops non-viral genetic therapies built on its Fusogenix Proteo-Lipid Vehicle (PLV) delivery platform, which delivers DNA and RNA payloads to tissues throughout the body and allows repeat dosing.

BiotechHealthtechLongevitySeattle, US

MSMatthew Scholz(Executive Officer, Director)inEric Garcia(Executive Officer)inStephen Hilbert(Executive Officer)JLJohn Lewis(Executive Officer)inGary Hudson(Executive Officer, Director)in

BoardDavid Gobel(Director)

Co-investorsIKIKJ CapitalMEMethuselah FundsHEHealthspan Capital

Renewal Bio is a biotechnology company conducting research related to aging and longevity.

Co-investorsGAGaingelsNFNFX

Repair Biotechnologies develops the Cholesterol Degrading Platform, a therapeutic approach for treating conditions caused by localized accumulations of excess cholesterol.

BiotechHealthtechMedical DevicesSyracuse, US

Guilherme Cherman Perdigao de Oliveira(Executive Officer, Director)Reason("CEO's full legal name is ""Reason""")Anthony Matthew Chow(Director)

BoardKelsey Moody(Director)

Co-investorsMEMethuselah FoundationQUquadraScope Venture FundTHThynk Capital

Revel Pharmaceuticals develops enzyme-based therapeutics designed to recognize and reverse molecular damage that accumulates in the body's structural tissue — collagen, elastin, and extracellular matrix — targeting age-related damage that drives disease.

BiotechDeep TechLongevitySan Francisco, US

ACAaron Cravens(Co-Founder & CEO)inJCJennifer Cochran(Director)

Co-investorsGAGaingels

Syntax Bio develops a discovery platform that accelerates stem cell-derived therapies by using its proprietary Cellgorithm technology to control and direct cell differentiation.

BiotechDeep TechMedical DevicesChicago, US

Ryan Clarke(Co-Founder, Chief Scientific Officer)inNBNiko Balanis, PhD(Co-Founder, Chief Technology Officer)inBrad Merrill, PhD(Co-Founder, Head of Innovation)MMMatt MacDougall, MD, PhD(Scientific Cofounder, Immunology Physician, Stanford University)inPatrick Shaddow(Executive Officer, Director)John Craighead, PhD(Chief Executive Officer)

Co-investorsASAstellas Venture Management LLCDCDCVC (Data Collective)DCDCVC BioDRDraper AssociatesILIllumina VenturesPOPortal Innovations+1 more

Vincere Biosciences develops small-molecule therapeutics targeting mitochondrial quality control and mitophagy, primarily for neurodegenerative diseases including Parkinson's disease.

AI & Machine LearningBiotechDeep TechLongevity

Co-investorsALAlumni VenturesBEBeiersdorf Innovation FundBEBeresford VenturesDRDraper AssociatesFRFreemind InvestmentsPOPortal Innovations+1 more