First Spark Ventures, Llc — Full Portfolio

Alljoined develops neural decoding technology using machine learning to enable computers to interpret human brain activity, aiming to enhance human capability, mental health, and interpersonal understanding.

AI & Machine LearningDeep TechDigital HealthHealthtechSan Francisco, US

JJonathan(CEO)AAnthony(Chief Scientific Officer)

Co-investorsANAngel Collective Opportunity FundCOCompoundCRCrosscourt VenturesEVEvolution VC PartnersMAMana VenturesTRTranspose Platform Management

ARIA (Advanced Research + Invention Agency) is a UK government R&D funding agency that provides grants and resources to scientists and engineers pursuing high-risk, high-reward scientific and technological breakthroughs.

AI & Machine LearningDeep TechGovTech

Confidencial provides data-centric security technology that protects sensitive information automatically at the point of creation or ingestion, for organizations across industries handling confidential documents and data.

AI & Machine LearningCybersecurityData & InfrastructureEnterprise Software

KEKarim Eldefrawy(CTO & Co-Founder)in

Co-investorsPEPerot Jain

Curve Pay is a digital wallet that combines multiple bank cards into one, letting users switch which card paid for a purchase after the fact, avoid foreign exchange fees, and earn cashback on top of existing card rewards.

ConsumerFintech

SBShachar Bialick(Founder)inAnna Mostyn-Williams(Founder)Frances "Franco" Stevens(Founder)Tom Foster-Carter(Founder)

Co-investorsCACathay InnovationCOCohen CircleFUFuel Venture CapitalGAGaingelsHAHanaco Venture CapitalLILifeX Ventures+12 more

Curve Bio builds Whole-Body Intelligence models from its Whole-Body Atlas, a molecular map of the body, to power blood tests that monitor organ health in chronic disease patients.

AI & Machine LearningBiotechDigital HealthDallas, US

NHNathan Hunkapiller(Founder)inProf. Shan Wang, PhD(Chief Innovation Officer and Scientific Founder)Ritish Patnaik, PhD(Chief Executive Officer)CHUBA OYOLU(Executive Officer)SHAN XIANG WANG(Executive Officer, Director)RITISH PATNAIK(Executive Officer, Director)

Co-investorsLILifeX VenturesLULuma GroupNZNZVCCICivilization Ventures Management, LlcMIMintaka

Endometrics is a molecular diagnostics company developing non-invasive tests for women's health that use menstrual blood as an organ-proximal liquid biopsy, with an initial focus on endometriosis.

AI & Machine LearningBiotechDigital HealthFemTechMedical DevicesSanta Clara, US

Dr. Aznavour(CEO & Founder)YAYana Aznavour(CEO & Founder)in

Co-investorsGRGranatus VenturesSUSupernode Ventures

Flower develops collaborative AI infrastructure and tools, including federated learning platforms, AI agents, and language models that enable organizations to build and deploy AI networks while maintaining data privacy and control.

AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareHamburg, DE

DJDaniel J. Beutel(Founder)inNLNic Lane(Founder)inTTTaner Topal(Founder)inJohn Diklev(Founder)Nicholas Lane(Founder)Marcel Roesberg(Vice President, Finance \u0026 Operations)

Co-investorsBEBetaworksFEFelicis VenturesMOMozilla VenturesPIPioneerY Y CombinatorBEBetaworks Ventures Management, Llc+5 more

Fundamental Research Labs builds autonomous, socially intelligent AI agents capable of reasoning and multi-agent collaboration.

AI & Machine Learning

NCNico Christie(Founder)in

Co-investorsANAndreessen HorowitzA1A16Z SpeedrunALAlumni VenturesCACastor VenturesFAFactorial FundsPAPatron+3 more

Inlyte Energy manufactures iron-sodium battery energy storage systems for utility-scale and industrial applications.

CleantechEnergyHardwareBerkeley, US

ABAntonio Baclig(Founder & CEO)WGWill Gent(Cofounder & VP of Engineering)in

BoardRWRichard Wang(Director)inLMLaurie Menoud(Director)in

Co-investorsATAt One VenturesCOCollaborative FundTETechEnergy VenturesVAValo VenturesCLClimate Capital

Inworld AI provides a full-duplex audio streaming platform that enables real-time conversational AI interactions with intelligent turn-taking, function calling, and multi-model routing capabilities for developers building conversational applications.

AI & Machine LearningDeveloper ToolsMountain View, US

IGIlya Gelfenbeyn(Founder)inKGKylan Gibbs(Founder)inMEMichael Ermolenko(Founder)in

Co-investorsA-A-Force VenturesBIBitkraft Esports VenturesBRBrave CapitalCRCRV (Charles River Ventures)DEDentsu VenturesDIDisney Accelerator+15 more

Latent AI builds tools and services for deploying, optimizing, and updating machine learning models at the edge, including in disconnected real-world environments across varied hardware and device fleets.

AI & Machine LearningDefense TechEnterprise Software

SCSek Chai(Founder)in

Co-investorsAUAUM VenturesBLBlackhorn VenturesBOBooz Allen VenturesDODoon CapitalFUFuture VenturesGRGrit Ventures+2 more

Nimble Science develops SIMBA Capsule Kits that enable researchers and commercial partners to study the small intestinal microenvironment; the company offers discounted access to these kits in exchange for research data and provides regulatory and clinical support services.

AI & Machine LearningBiotechDigital HealthHealthtechMedical Devices

SBSabina Bruehlmannin

Co-investorsALAlumni VenturesFUFusionJOJoyance PartnersSESeventure PartnersSTStartup TNTTHThin Air Labs+3 more

Normal is an applied research lab focused on AI for hardware design, providing data and evaluation methods to advance AI capabilities.

Advanced ManufacturingAI & Machine LearningDeep TechHardwareSan Francisco, US

AYAnson Yu(CEO)inHNHudhayfa Nazoordeen(Founder)inAntonio Martinez(Founder)Faris Sbahi(Founder)Matthias Tan(Founder)

Co-investorsARArcTern VenturesY Y CombinatorBABase Case CapitalDRDrive CapitalGOGolden VenturesMIMichael Chen+3 more

Normal builds open, AI-powered building automation software for portfolio managers, replacing siloed legacy systems with unified dashboards and centralized control across multiple properties.

AI & Machine LearningCloud ComputingEnterprise SoftwareIoTPropTechSaaS

Co-investorsARArcTern VenturesZIZigg CapitalDRDrive CapitalLALaude VenturesMIMicron VenturesSASamsung Catalyst Fund

Normal Computing develops software and hardware infrastructure optimizing AI models for physical systems through custom silicon design and advanced EDA tools.

AI & Machine LearningDeep TechDeveloper ToolsHardwareSemiconductorsSan Francisco, US

FSFaris Sbahi(Executive Officer, Director)inAMAntonio Martinez(Founder)inMTMatthias Tan(Founder)inASAaron Sisto(Director)inYui-Hong Matthias Tan(Executive Officer, Director)

BoardSFSteve Fu(Director)in

Co-investorsCECelesta CapitalDRDrive CapitalMIMicron VenturesSASamsung Catalyst FundSASamsung NextVIView Different

High quality outpatient surgical care.

Co-investorsMCMcKesson VenturesSTStar51 CapitalTATau Ventures

Radical Numerics develops AI models and architectures built for biology, including multimodal generative models trained on biological data to support genomic discovery and gene-editing.

AI & Machine LearningBiotechDeep Tech

Eric Nguyen(Founder)inMichael Poli(Founder)in

Co-investorsOBObvious VenturesSASabrina Hahn FundTRTranspose Platform ManagementEMEmergence Capital PartnersTRTriatomic Capital

Simulon builds an iPhone-based visual effects app that composites photorealistic 3D assets into live-action footage.

Co-investorsGMGMG VenturesMEMercuri.vc

SoloPulse develops advanced physics-based and AI-powered systems for threat detection and intelligence gathering, offering SIGMA™ for payload-based situational awareness and NOVA™ for synthetic aperture radar processing across unmanned and satellite platforms.

AI & Machine LearningDeep TechDefense Tech

Co-investorsCACantos VenturesCOCollaborative FundCRCrosscut Ventures

SynthLabs develops reinforcement learning methods for large reasoning models, such as Adaptive Length Penalty (ALP), which adjusts generation length to problem difficulty to reduce token usage.

AI & Machine LearningDeep Tech

NLNathan Lile(Founder)inFDFrancis deSouza(Founder)in

Co-investorsM1M12 (Microsoft's Venture Fund)

Thales develops products and solutions in defence, security, cybersecurity, digital identity, and aerospace for businesses, organisations, and governments.

CybersecurityDefense TechSpace Tech

Co-investorsNENewionSTStageOne Ventures

Tidal Metals uses patented electrochemical technology to produce primary magnesium from seawater or desalination brine using clean electricity, aiming to re-establish domestic magnesium production in the United States.

CleantechDeep TechNew Materials

HYHoward Yuh(Founder)in

Co-investorsDCDCVC (Data Collective)SCScrum Ventures

Unnatural Products is a drug discovery platform company that develops synthetic macrocycles to target previously undruggable disease targets.

AI & Machine LearningBiotechDeep TechMedical DevicesSanta Cruz, US

CPCameron Pye(Co-Founder & CEO)inJoshua Schwochert(Co-Founder & CSO)in

BoardVBVasudev Bailey(Director)in

Co-investorsABAbstract VenturesARArtis VenturesASAsset Management CompanyBEBetter Ventures Central LlcBLBlue Bear VenturesCOColorcon Ventures+10 more

Valitor develops bioactive molecule therapies using a multivalent biopolymer technology platform to create long-acting treatments for ophthalmologic diseases, with its lead candidate VLTR-559 targeting wet age-related macular degeneration.

BiotechMedical DevicesBerkeley, US

WJWesley Jackson(President, Chief Scientific Officer & Member of the Board)inGDGregory D. Kunst(Chief Executive Officer)Carole H Bellis(Executive Officer)Kevin E Healy(Director)Jackson M Wesley(Executive Officer, Director)

BoardDLDrew Lanza(Director)in

Co-investorsANAngel Physicians FundBEBerkeley CatalystEXExSight VenturesPAPandect BioventuresTATaihill Venture

Vitara Biomedical develops medical technology for the care of extremely premature newborns.

BiotechDeep TechHealthtechMedical DevicesPhiladelphia, US

Bernard Lyons(Executive Officer, Director)inJMJames McGlone(Executive Officer, Director)inJeffrey Kahn(Executive Officer)Jim McGlone(Founder)

BoardThomas Todorow(Director)Ian Ratcliffe(Director)

Co-investorsGVGV (Google Ventures)JAJazzya InvestmentsKHKhosla VenturesMYMyelin VC

Walking Fish Therapeutics develops cell therapies aimed at restoring health and function in patients.

AI & Machine LearningBiotechHealthtechMedical DevicesSouth San Francisco, US

Lewis Williams(Co-founder & CEO)inRusty Williams(Founder)Antonin de Fougerolles(Director)Momo Wu(Director)Stella Xu(Director)Alexis Ji(Director)

Co-investorsPAPandect BioventuresILIllumina VenturesNONorthpond Ventures

Xona Space Systems operates Pulsar, a positioning, navigation, and timing (PNT) service delivered from a constellation of small satellites in Low Earth Orbit that broadcasts a new signal to augment or replace GPS.

Deep TechHardwareSpace TechBurlingame, US

BMBrian Manning(Co-founder and CEO)inTRTyler Reid(Co-founder and CTO)inAdrien Perkins(Co-founder and SVP of Engineering)inPaul Tarantino(Founder)Jay Zaveri(Director)Kaz Gunning(Co-founder and VP of Navigation Service)

Co-investorsALAloniqARArmada Investment AGBEBeyond Earth VenturesCACapital InnovatorsCRCraft VenturesCRCross Culture Ventures+21 more