First Spark Ventures, Llc β Full Portfolio
31 tracked investments Β· listed companies and verified rows first
FIGUR8 is an FDA-registered platform that provides objective, actionable insights for musculoskeletal health diagnosis and treatment.
AI & Machine LearningHardwareHealthtechMedical DevicesBoston, US
Nan-Wei Gong(Founder and Chief Executive Officer)in
Co-investorsPhoenix Venture PartnersChloe CapitalConvergent VenturesDigiTx Partners LLCEvolution VC PartnersGRIDS Capital+3 more
Alljoined develops neural decoding technology using machine learning to enable computers to interpret human brain activity, aiming to enhance human capability, mental health, and interpersonal understanding.
AI & Machine LearningDeep TechDigital HealthHealthtechSan Francisco, US
Jonathan(CEO)Anthony(Chief Scientific Officer)
Co-investorsAngel Collective Opportunity FundCompoundEvolution VC PartnersTranspose Platform Management
Confidencial provides data-centric security technology that protects sensitive information automatically at the point of creation or ingestion, for organizations across industries handling confidential documents and data.
AI & Machine LearningCybersecurityData & InfrastructureEnterprise Software
Karim Eldefrawy(CTO & Co-Founder)in
Co-investorsPerot Jain
Curve Pay is a digital wallet that combines multiple bank cards into one, letting users switch which card paid for a purchase after the fact, avoid foreign exchange fees, and earn cashback on top of existing card rewards.
ConsumerFintech
Shachar Bialick(Founder & CEO)in
Co-investorsCohen CircleFuel Venture CapitalHanaco Venture CapitalLifeX VenturesMouro CapitalOutward VC+7 more
Curve Bio builds Whole-Body Intelligence models from its Whole-Body Atlas, a molecular map of the body, to power blood tests that monitor organ health in chronic disease patients.
AI & Machine LearningBiotechDigital HealthDallas, US
Nathan Hunkapiller(Founder)inProf. Shan Wang, PhD(Chief Innovation Officer and Scientific Founder)Ritish Patnaik, PhD(Chief Executive Officer)
Co-investorsLifeX VenturesNZVC
Endometrics is a molecular diagnostics company developing non-invasive tests for women's health that use menstrual blood as an organ-proximal liquid biopsy, with an initial focus on endometriosis.
BiotechDigital HealthFemTechSanta Clara, US
Dr. Aznavour(CEO & Founder)Yana Aznavour(CEO & Founder)in
Co-investorsGranatus VenturesSupernode Ventures
Flower develops collaborative AI infrastructure and tools, including federated learning platforms, AI agents, and language models that enable organizations to build and deploy AI networks while maintaining data privacy and control.
AI & Machine LearningData & InfrastructureEnterprise SoftwareHamburg, DE
Daniel J. Beutel(Founder)inNic Lane(Founder)inTaner Topal(Founder)inNicholas Lane(Founder)in
Co-investorsBetaworksFelicis VenturesMozilla VenturesY Combinator
Flower builds a full-stack platform for collaborative and federated AI, including a federated learning framework (Flower SuperGrid), an LLM (Flower Model), and an AI agent (Flower Agent), enabling model training across decentralized data without centralizing it.
AI & Machine LearningData & InfrastructureDeveloper Tools
Fundamental Research Labs builds autonomous, socially intelligent AI agents capable of reasoning and multi-agent collaboration.
AI & Machine Learning
Nico Christie(Founder)in
Co-investorsAndreessen HorowitzA16Z SpeedrunCastor VenturesFactorial FundsPatronVamosVentures+3 more
Inlyte Energy manufactures iron-sodium battery energy storage systems for utility-scale and industrial applications.
CleantechEnergyHardwareBerkeley, US
Antonio Baclig(Founder & CEO)Will Gent(Cofounder & VP of Engineering)in
BoardRichard Wang(Director)inLaurie Menoud(Director)in
Co-investorsAt One VenturesTechEnergy VenturesValo VenturesClimate Capital
Inworld AI provides a full-duplex audio streaming platform that enables real-time conversational AI interactions with intelligent turn-taking, function calling, and multi-model routing capabilities for developers building conversational applications.
AI & Machine LearningDeveloper ToolsMountain View, US
Ilya Gelfenbeyn(Founder)inKylan Gibbs(Founder)inMichael Ermolenko(Founder)in
Co-investorsBitkraft Esports VenturesBrave CapitalCRV (Charles River Ventures)Dentsu VenturesDisney AcceleratorIntel Capital+11 more
Latent AI builds tools and services for deploying, optimizing, and updating machine learning models at the edge, including in disconnected real-world environments across varied hardware and device fleets.
AI & Machine LearningDefense TechEnterprise Software
Co-investorsBlackhorn VenturesBooz Allen VenturesDoon CapitalFuture VenturesGrit VenturesLockheed Martin Ventures
Nimble Science develops SIMBA Capsule Kits that enable researchers and commercial partners to study the small intestinal microenvironment; the company offers discounted access to these kits in exchange for research data and provides regulatory and clinical support services.
AI & Machine LearningBiotechDigital HealthHealthtechMedical Devices
Co-investorsFusionStartup TNTThin Air LabsUCeed FundsBoxOne VenturesSeventure Partners
Normal is an applied research lab focused on AI for hardware design, providing data and evaluation methods to advance AI capabilities.
Advanced ManufacturingAI & Machine LearningDeep TechHardwareSan Francisco, US
Anson Yu(Founder)inHudhayfa Nazoordeen(Founder)in
Co-investorsY CombinatorMicron VenturesSamsung Catalyst Fund
Normal builds open, AI-powered building automation software for portfolio managers, replacing siloed legacy systems with unified dashboards and centralized control across multiple properties.
AI & Machine LearningCloud ComputingEnterprise SoftwareIoTPropTechSaaS
Co-investorsArcTern VenturesZigg CapitalDrive CapitalLaude VenturesMicron VenturesSamsung Catalyst Fund
Normal Computing develops software and hardware infrastructure optimizing AI models for physical systems through custom silicon design and advanced EDA tools.
AI & Machine LearningDeep TechDeveloper ToolsHardwareSemiconductorsSan Francisco, US
Faris Sbahi(Executive Officer, Director)inAntonio Martinez(Founder)inMatthias Tan(Founder)inAaron Sisto(Director)inYui-Hong Matthias Tan(Executive Officer, Director)
Co-investorsCelesta CapitalCelesta CapitalDrive CapitalSamsung Catalyst FundSamsung NextMicron Ventures
Radical Numerics develops AI models and architectures built for biology, including multimodal generative models trained on biological data to support genomic discovery and gene-editing.
AI & Machine LearningBiotechDeep Tech
Eric Nguyen(Founder)inMichael Poli(Founder)in
Co-investorsObvious VenturesEmergence CapitalEmergence Capital PartnersTriatomic Capital
Simulon builds an iPhone-based visual effects app that composites photorealistic 3D assets into live-action footage.
Co-investorsGMG VenturesMercuri.vc
SoloPulse develops advanced physics-based and AI-powered systems for threat detection and intelligence gathering, offering SIGMAβ’ for payload-based situational awareness and NOVAβ’ for synthetic aperture radar processing across unmanned and satellite platforms.
AI & Machine LearningDeep TechDefense Tech
Co-investorsCrosscut VenturesCantos Ventures
SynthLabs develops reinforcement learning methods for large reasoning models, such as Adaptive Length Penalty (ALP), which adjusts generation length to problem difficulty to reduce token usage.
AI & Machine LearningDeep Tech
Nathan Lile(Founder)inFrancis deSouza(Founder)in
Co-investorsM12 (Microsoft's Venture Fund)
Tidal Metals uses patented electrochemical technology to produce primary magnesium from seawater or desalination brine using clean electricity, aiming to re-establish domestic magnesium production in the United States.
CleantechDeep TechNew Materials
Howard Yuh(Founder)in
Co-investorsDCVC (Data Collective)
Unnatural Products is a drug discovery platform company that develops synthetic macrocycles to target previously undruggable disease targets.
AI & Machine LearningBiotechDeep TechMedical DevicesSanta Cruz, US
Cameron Pye(Co-Founder & CEO)inJoshua Schwochert(Co-Founder & CSO)in
BoardVasudev Bailey(Director)in
Co-investorsAbstract VenturesArtis VenturesAsset Management CompanyBetter Ventures Central LlcBlue Bear VenturesDroia Ventures+6 more
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Valitor develops bioactive molecule therapies using a multivalent biopolymer technology platform to create long-acting treatments for ophthalmologic diseases, with its lead candidate VLTR-559 targeting wet age-related macular degeneration.
BiotechMedical DevicesBerkeley, US
Wesley Jackson(President, Chief Scientific Officer & Member of the Board)inGregory D. Kunst(Chief Executive Officer)Carole H Bellis(Executive Officer)Kevin E Healy(Director)Jackson M Wesley(Executive Officer, Director)
BoardDrew Lanza(Director)in
Co-investorsAngel Physicians FundBerkeley CatalystExSight VenturesPandect BioventuresExSight
Vitara Biomedical develops medical technology for the care of extremely premature newborns.
BiotechDeep TechHealthtechMedical DevicesPhiladelphia, US
Bernard Lyons(Executive Officer, Director)inJames McGlone(Executive Officer, Director)inJeffrey Kahn(Executive Officer)
BoardThomas Todorow(Director)Ian Ratcliffe(Director)Manish Kothari(Director)in
Co-investorsJazzya InvestmentsKhosla VenturesMyelin VC
Walking Fish Therapeutics develops cell therapies aimed at restoring health and function in patients.
AI & Machine LearningBiotechHealthtechMedical DevicesSouth San Francisco, US
Lewis Williams(Co-founder & CEO)inRusty Williams(Founder)Antonin de Fougerolles(Director)Momo Wu(Director)Stella Xu(Director)Alexis Ji(Director)
Co-investorsPandect BioventuresNorthpond Ventures
Xona Space Systems operates Pulsar, a positioning, navigation, and timing (PNT) service delivered from a constellation of small satellites in Low Earth Orbit that broadcasts a new signal to augment or replace GPS.
Deep TechHardwareSpace TechBurlingame, US
Brian Manning(Executive Officer, Director)inTyler Reid(Director)inAdrien Perkins(Director)
BoardSky Dayton(Director)inLewis Jones(Director)inJeff Crusey(Director)in
Co-investorsArmada Investment AGBeyond Earth VenturesCapital InnovatorsCross Culture VenturesIceNineIndustrious Ventures+16 more
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Other
Tracked investments with no reachable website or further public details β typically companies that wound down, renamed, or were absorbed.
Curve BiosciencesFundamental LabsOathOath SurgicalSolopulse
Rows marked βSEC filingβ are inferred from directors named on the company's SEC Form D β public regulatory data, not a portfolio list published by the firm.