Portal Innovations — Full Portfolio

Cardiosense develops wearable sensing hardware and deep-learning algorithms that convert physiological signals into clinical insights for cardiovascular disease detection and management.

AI & Machine LearningDigital HealthHealthtechMedical DevicesChicago, US

OIOmer Inan(Co-founder, Chief Scientific Officer)inACAndrew Carek(Co-founder, Chief Technical Officer)inAGAmit Gupta(Co-founder, Advisor)inMEMozziyar Etemadi(Co-founder, Head of AI)OIOmer Inan, PhD(Co-founder, Chief Scientific Officer)inACAndrew Carek, PhD(Co-founder, Chief Technical Officer)in

Co-investorsBABayMed Venture PartnersBRBroadview VenturesCRCross-Border Impact VenturesLALaerdal Million Lives FundOSOSF VenturesARArboretum Ventures+1 more

CiRC Biosciences develops cellular reprogramming therapies that convert fibroblasts directly into specific neurons and cell types lost in degenerative eye and brain diseases.

BiotechDeep TechMedical DevicesChicago, US

Darien Parhad(Executive Officer)Patrick Morris(Executive Officer, Director)Sai Chavala(Director)

BoardTimothy Cunniff(Director)AGAntonio Gracias(Director)inJeffrey Aronin(Director)

Co-investorsPAParagon Biosciences LLCVAValor Equity Partners

ClostraBio develops next-generation probiotics and a platform for delivering bacterial metabolites to support gut health, targeting inflammatory bowel disease (IBD) and food allergy.

BiotechDigital HealthHealthtechChicago, US

Jeffrey Hubbell(Secretary)CNCathryn Nagler(President)inBrett Newswanger(Chief Operating Officer)

BoardJFJohn Flavin(Executive Chairman)in

Co-investorsSTStone Mountain Ventures

CrossBridge Bio, launched in 2023, develops next-generation antibody-drug conjugates (ADCs) to address a range of cancer indications.

BiotechHealthtechHouston, US

KTKyoji Tsuchikama(Executive Officer, Director, Promoter)MTMichael Torres(Executive Officer, Director, Promoter)

BoardWFWilliam F. McKeon(Director)Damir Illich(Director)Patrick James Crutcher(Director)

Co-investorsTMTMC Venture FundPOPortal

cTRL is a biotech company developing cell-based immunotherapies for cancer, drawing on expertise in the adaptive immune system, immuno-oncology, biomedical engineering, and cell therapy research and development.

BiotechDeep TechHealthtech

Dimension Bio is a biotechnology company developing regenerative therapeutics using its BioNidum platform, which combines materials science, 3D printing, and digital manufacturing to produce implantable and injectable biosynthetic scaffolds that promote tissue healing.

BiotechHealthtechMedical DevicesNew MaterialsChicago, US

CNCaralynn Nowinski Collens, M.D.(Co-founder & CEO)inRSRamille Shah, Ph.D.(Co-founder & CSO)CCCaralynn Collens(Executive Officer, Director)inCNCaralynn Nowinski Collens(Co-founder & CEO)inRamille Shah(Co-founder & CSO)AJAdam Jakus(Co-Founder)in

Co-investorsBEBetter Ventures Central LlcHAHAWKTAILLOLofty VenturesPAPathway BioventuresSOSolas BioVenturesALAlumni Ventures+2 more

Grove Biopharma develops Bionic Biologics, a drug discovery platform combining AI-enabled molecular design, precision polymer chemistry, and experimental biology to target protein-protein interactions that are inaccessible to conventional therapeutics.

AI & Machine LearningBiotechDeep TechChicago, US

GDGeoffrey Duyk(CEO)inGMGeoffrey M. Duyk, M.D., Ph.D.(Chief Executive Officer)in

Co-investorsDCDCVC (Data Collective)DCDCVC BioINInVivium Capital

Inomagen Therapeutics develops a non-viral gene therapy delivered via a single-dose, minimally invasive procedure to target the underlying mechanisms of atrial fibrillation.

BiotechHealthtechMedical DevicesChicago, US

RARishi Arora(Founder)GAGerard Abate(Chief Medical Officer)ESEric Sandberg(Chief Business Officer)in

BoardMarc Penn(Director)James R. Vogler(Director)

Iterion Therapeutics is a clinical-stage biopharmaceutical company developing cancer therapies targeting the Wnt/β-catenin pathway.

BiotechHealthtech

RARahul Aras(Chief Executive Officer)inOTOvid Trifan(Chief Medical Officer)inSHSteve Horrigan(Chief Scientific Officer)in

Co-investorsGRGreen Park & Golf VenturesLULumira Ventures

March Bioscience is a cell therapy company assembling leading scientists and drug developers to advance cell therapy treatments.

BiotechMedical DevicesHouston, US

SHSarah Hein(CEO, Co-Founder)inMaksim Mamonkin(Co-Founder, Chair Scientific Advisory Board)MBMalcolm Brenner(Co-founder)

BoardTLThomas Luby(Director)inPeter Olagunju(Director)inJoseph Petrosino(Director)

Co-investorsMIMission Biocapital4B4BIO CapitalCACancer FundFIFitz Gate VenturesMOModi VenturesTMTMC Venture Fund+1 more

Moonlight Therapeutics is a clinical-stage biotech company developing an intradermal stamp-based immunotherapy for people with food allergies.

BiotechHealthtech

Co-investorsALAllerfund Ventures, Llc

NovaScan develops a platform technology combining AI and spectral bioimpedance for oncology applications, with multiple diagnostic and intraoperative products built on a shared hardware and software foundation currently in clinical trials.

AI & Machine LearningHealthtechMedical Devices

Co-investorsDIDipalo VenturesGRGreen Park & Golf Ventures

Pelagos Pharma develops drugs targeting hard-to-treat receptors for age-related diseases, with a focus on extending healthspan and longevity.

BiotechDeep TechHealthtechLongevity

Reaxbio develops a chemoproteomics platform that identifies and targets novel protein sites for drug discovery across disease-relevant biological contexts.

AI & Machine LearningBiotechDeep Tech

JMJeff Montgomery(Founder)in

Co-investorsOMOMX Ventures

Rhaeos develops FlowSense, a noninvasive wireless wearable skin patch that monitors fluid flow in the body, initially targeting hydrocephalus patients who depend on implantable shunts for cerebrospinal fluid management.

HardwareHealthtechMedical DevicesEvanston, US

Dr. Chad WebbJAJohn A. Rogers(Executive Officer, Director)RGRoozbeh Ghaffari(Director)inALAnna Lisa Somera(Executive Officer)inChad Seaver(Director)R. Chad Webb(Executive Officer, Director)

Co-investorsCRCreative VenturesLALateral Capital

RNAV8 Bio develops a toolkit for engineering mRNA therapeutics, optimizing non-coding sequences to improve expression and efficacy of mRNA-based treatments.

AI & Machine LearningBiotechLaguna Niguel, US

Devan ShahinMLMichelle Lynn Hall

Co-investorsBIBioBritELElmehøj VenturesSEService Provider Capital

Synaptrix develops NOVABLOC, a non-opioid neuromodulation therapy that uses electrical stimulation to provide targeted, long-lasting postoperative pain relief.

BiotechDigital HealthMedical DevicesAlpharetta, US

Shyamy Sastry(Executive Officer, Director)

BoardDoug Reed(Director)Robert Crutchfield(Executive Officer, Director)AWAnita Watkins(Director)inKurt Jacobus(Director)in

Co-investorsHAHatteras Venture Partners

Syntax Bio develops a discovery platform that accelerates stem cell-derived therapies by using its proprietary Cellgorithm technology to control and direct cell differentiation.

BiotechDeep TechMedical DevicesChicago, US

Ryan Clarke(Co-Founder, Chief Scientific Officer)inNBNiko Balanis, PhD(Co-Founder, Chief Technology Officer)inBrad Merrill, PhD(Co-Founder, Head of Innovation)MMMatt MacDougall, MD, PhD(Scientific Cofounder, Immunology Physician, Stanford University)inPatrick Shaddow(Executive Officer, Director)John Craighead, PhD(Chief Executive Officer)

Co-investorsASAstellas Venture Management LLCDCDCVC (Data Collective)DCDCVC BioDRDraper AssociatesILIllumina VenturesWAWalder Ventures

Syntis Bio develops oral therapies that use the biology of the small intestine to treat conditions ranging from rare genetic disorders to common diseases.

BiotechDeep TechDigital HealthHealthtechBoston, US

RDRahul Dhanda(Executive Officer, Director)inCGCarlo Giovanni Traverso(Director)RLRobert Langer(Director)

BoardTBTeymour Boutros-Ghali(Director)inTBTEYMOUR BOUTROS-GHALI(Director)inMartin Madaus(Director)

Co-investorsBIBill & Melinda Gates FoundationBOBold Capital PartnersCECerity Partners VenturesSASafar PartnersSKSky9 Capital

Transcera is a biotech company developing a new class of therapeutics that use lipid trafficking pathways to direct extracellular proteins into lysosomes for degradation, aimed at treating chronic diseases.

BiotechDeep TechBoston, US

WLWayne Lencer(Co-Founder & SAB Chair)HGHunter Goble(Co-Founder & CEO)inJWJustin Wolfe(Co-Founder & CSO)in

Co-investorsTATau VenturesDIDigitalis VenturesKDKdT VenturesPEPear VCTATAU VenturesXOXora Innovation Pte Ltd

Vincere Biosciences develops small-molecule therapeutics targeting mitochondrial quality control and mitophagy, primarily for neurodegenerative diseases including Parkinson's disease.

AI & Machine LearningBiotechDeep TechLongevity

Co-investorsBEBeiersdorf Innovation FundBEBeresford VenturesDRDraper AssociatesQUquadraScope Venture Fund

Vivtex is a drug development company applying computational science and pre-clinical research to advance new medicines.

AI & Machine LearningBiotechDeep TechMedical DevicesCambridge, US

TVThomas von Erlach(CEO & Co-founder)inRLRobert Langer(Co-founder)GTGiovanni Traverso(Co-founder)JAMES WINSCHEL(Executive Officer, Director)JUAN LOPEZ(Executive Officer)JACQUES BARBUT(Director)

Walder Ventures is a mission-driven investment vehicle established by Joseph and Elizabeth Walder to support programs and organizations benefiting the Chicago region, with a focus on life sciences and sustainability.

BiotechImpact & Social GoodChicago, US

Joseph Walder(Co-founder)EWElizabeth Walder(Co-founder & President)

Zylem Biosciences develops Metabolic Redox Modulators (MRMs), a patented platform of drug candidates targeting the SR-B1 receptor to treat cancer, cardiovascular disease, and other age-related conditions.

BiotechLongevityMedical Devices

STShad Thaxton(MD, PhD)Kaylin McMahon(PhD)Philip Bligh

BoardJay Venkatesan(MD, MBA)Leo Gordon(MD)