About
Laurence Midgley co-founded Ångström AI, which develops molecular simulation software for pharmaceutical and biotechnology companies. He previously worked as a research engineer at InstaDeep and completed a PhD at the University of Cambridge focused on generative AI for molecular systems.
Laurence Midgley @silkydogfish
The highlight of this project has been working closely with @AstraZeneca's CSP team for the past several months to understand how they do CSP and how @Angstrom_ai can build something useful for them! 5/5
May 29, 2026 · ♥ 4 · ⇄ 1
Laurence Midgley @silkydogfish
Density functional theory (DFT) is the current workhorse of CSP in pharma. While valuable, these calculations take days to weeks. CSP-MACE-Å matches DFT accuracy and is 10,000 times faster - so we can cut this down to minutes! Furthermore, the speed improvement allows for far
May 29, 2026 · ♥ 2 · ⇄ 1
Laurence Midgley @silkydogfish
Alongside experimental screening, computational characterisation of possible crystal forms is an important way for pharma companies to mitigate these risks. See this video by @veritasium for an awesome explanation of the importance of crystal polymorphism: https://t.co/fvmeR7muvK
May 29, 2026 · ♥ 4 · ⇄ 3
Founder at Ångström AIYC S24
Intro paths
Laurence went through Y Combinator (Summer 2024) — any YC alum in your network can reach them through the YC community.
Their group partner at YC was Ankit Gupta, General Partner at Y Combinator — the partner who ran Ångström AI's batch and knows the company first-hand. YC profile ↗
In turn, Laurence can intro founders to Ångström AI's investors below.
Ångström AI's investors · 5
Co-founders at Ångström AI
