Deep Tech Startups

Odyssey is an AI lab developing general world models trained on multimodal observations of the physical world. The company builds foundational AI systems including Odyssey-2, Starchild-1, and Agora-1 for advancing physical simulation and multi-agent interaction.

13 investors

Helicons develops a peptide-based therapeutic platform designed to target intracellular proteins previously considered undruggable by combining the specificity of antibodies with the cell-penetrating properties of small molecules. The platform uses AI and simulation to engineer helical peptides with non-canonical amino acids for precision binding across a range of therapeutic applications.

13 investors

Red 6 develops augmented reality flight training technology for military aviators, enabling pilots and autonomous systems to train together in simulated threat environments. Its focus is on defense and military flight training applications.

13 investors

Senti Bio develops cell and gene therapies for cancer and difficult-to-treat diseases using synthetic biology and engineered Gene Circuits to enhance precision, control, and selectivity in targeting tumor cells. The company is a clinical-stage biotech firm leveraging proprietary platform technology across multiple cell types and modalities.

13 investors

Siren develops technology for early detection of diabetic foot ulcers to reduce injury risk. The company serves healthcare providers and patients managing diabetes.

13 investors

Solarcore develops aerogel-based thermal insulation technology, derived from NASA aerogel research, for use in consumer, commercial, and government applications such as footwear and outdoor gear. Its insulation is licensed to product makers, including Helly Hansen's BiFrost work boot rated to -40°C.

13 investors

Umbra designs, builds, tests, and operates satellite systems with precision radar imagery capabilities for space-based missions and intelligence applications. The company provides end-to-end spacecraft and sensor solutions for government and defense customers globally.

13 investors

Zanskar develops geothermal energy projects using AI and advanced geoscience to map subsurface resources and deliver utility-scale, carbon-free power. The company operates projects in the western United States that provide 24/7 firm power generation.

13 investors

ALETHIA AI builds AI systems at the intersection of artificial intelligence and blockchain, having introduced intelligent NFTs (iNFTs) and now developing autonomous agents and decentralized, user-owned AI. The company works with the AI Protocol, a permissionless framework for agentic AI, through research, model development, and on-chain deployments.

12 investors

Anjuna provides software that runs applications and data inside hardware-encrypted secure enclaves across major chip, cloud, and system vendors, protecting them from malware, insiders, and other threats. Its "lift and shift" approach lets enterprises achieve confidential computing protection without recoding applications.

12 investors

Axiom Math is a platform that enables users to test proof verification, extract theorems, and experiment with proof transformations quickly.

12 investors

Big Hat Bio develops therapeutics under development across multiple programs. The company is a STEM-focused team working on therapeutic discovery and development.

12 investors

BioOrbit produces pharmaceutical-grade crystals in microgravity environments via space-based facilities, enabling development of biologic drugs and treatments for patients. The company bridges orbital research with terrestrial medicine to make advanced pharmaceutical manufacturing accessible beyond hospital settings.

12 investors

BO Materials develops novel materials for industrial applications across trillion-dollar industries. The company creates new material solutions to solve technical problems and reduce conventional trade-offs.

12 investors

Chemify builds automated chemical synthesis systems combining chemistry, AI, and robotics to digitize molecular design and manufacturing. The company serves pharmaceutical, materials, and chemical discovery partners seeking faster and more scalable access to novel molecules and drugs.

12 investors

EarthGrid is a company focused on building energy grid infrastructure, presenting a team with engineering, safety, logistics, and finance roles. The page does not describe a specific product beyond its team.

12 investors

Eli develops and manufactures at-home hormone level tests that collect longitudinal data on daily hormonal patterns. The company serves individuals interested in tracking their hormone levels through accessible, simple testing.

12 investors

Emerald AI develops software to enable power flexibility in data centers by orchestrating power demand in response to grid needs. The company applies AI and machine learning to optimize cloud computing systems for grid-aware operations.

12 investors

Exodigo maps utilities, foundations, and geotechnical conditions beneath infrastructure projects without excavation, using multi-sensor fusion and AI to produce subsurface maps, insights, and visualizations. It serves infrastructure, transit, and utility teams to reduce underground risk during planning, design, and construction.

12 investors

Fabric8Labs develops Electrochemical Additive Manufacturing (ECAM), a room-temperature metal 3D printing technology that produces dense, high-purity metal parts with micron-scale resolution and no post-processing. Its patented microelectrode array printhead enables mass-scale production of components, including direct printing onto temperature-sensitive substrates such as PCBs, silicon, and existing metal parts.

12 investors

Formlabs designs and manufactures professional desktop 3D printers using stereolithography (SLA) and selective laser sintering (SLS) technologies, along with proprietary materials and software. Its customers span industries including medical research, footwear, automotive and aerospace manufacturing, as well as entrepreneurs and small businesses.

12 investors

Harmonic builds an advanced reasoning engine, a mathematical and computational tool for solving complex problems across scientific and technical domains.

12 investors

Icarus designs and manufactures solar-powered autonomous aircraft that fly for months at the edge of space. The company serves applications requiring long-duration stratospheric surveillance and monitoring.

12 investors

IonQ builds trapped-ion quantum computing systems along with quantum networking, sensing, and security products, offering commercial systems accessible through major cloud providers and integration with common quantum libraries. It serves enterprise and government customers across applications such as chemistry simulation, materials science, AI model fine-tuning, and quantum-secure communications.

12 investors