/Companies

Siren Care

500 Global '16Plug and Play Ventures

San Francisco, US · Founded 2016 · 28 employees on LinkedIn · 13 known investors

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Siren develops technology for early detection of diabetic foot ulcers to reduce injury risk. The company serves healthcare providers and patients managing diabetes.

Also known as Siren · Siren Socks

Founders & leadership

Siren Care was founded in 2016 by Ran Ma, Jie Fu, and Henk Jan Scholten.

RMRan Ma
Ran MaCo-Founder, CEO
JFJie Fu
Jie FuCo-Founder, CTO
HJHenk Jan Scholten
Henk Jan ScholtenCo-Founder, COO

Investors · 13

500 Globallisted by 500 GlobalPalo Alto · $150K

How we know: open dataset · Top 3000 Accelerator Startups (no YC) 2026-08 · open dataset · 500 Global portfolio 2026-08 · Not right? Tell us

FundersClubreportedSan Francisco · $290K

How we know: a partner's Signal profile · Not right? Tell us

Plug and Play VenturesreportedSilicon Valley · $50K – $400K

How we know: open dataset · Top 3000 Accelerator Startups (no YC) 2026-08 · Not right? Tell us

Company profile

researched Aug 2026

Siren Care develops Siren Socks, wearable socks that continuously measure foot temperature to help identify early signs of injury in people living with diabetes. Rising foot temperature is used as an indicator of developing inflammation, which may signal an injury that could progress to a diabetic foot ulcer. The company positions the product as a way to reduce ulcer risk through earlier detection.

The offering combines the socks with a monitoring service: licensed nurses review the temperature data for signs of inflammation and call patients regularly to check on their health, while providers are alerted to potential injuries and decide whether a clinic visit is warranted. The socks are designed for daily wear and require no smartphone and no charging; they are machine washable and are replaced automatically as they wear down. Siren cites published research (Lavery et al., Diabetes Care, 2004) indicating that home temperature monitoring has been shown to reduce diabetic foot ulcers by up to 87.5%.

Business model

Siren supplies its temperature-sensing socks together with an ongoing remote monitoring service staffed by licensed nurses, with worn socks replaced automatically, and it works alongside providers who receive alerts and manage patient care.

Traction

The company publishes testimonials from a patient with type 1 diabetes who credits Siren notifications with catching Charcot foot symptoms, and from a Bay Area podiatrist whose patients use the socks for prevention of diabetic foot sores.

▸Full profile — market position, technology, go-to-market

Market position

Siren focuses on early detection of diabetic foot ulcers, a condition it describes as affecting more than 30% of people with diabetes over their lifetime, with 10% of those ulcers resulting in amputation.

Technology

Socks with embedded sensing that continuously measure foot temperature as an early indicator of inflammation and injury; the design requires no smartphone connection and no charging, and the socks are machine washable.

Go-to-market

Siren addresses both patients and providers directly through separate paths on its website, and cites podiatrist users of the product.

People living with diabetes who are at risk of foot ulcers, and the healthcare providers such as podiatrists who manage their foot care.

Compiled by commissioned research from 1 cited public sources — announcements, filings, and press listed under research sources below.

Key figures

latest reported
Lifetime risk of foot ulcer among people with diabetes (cited)Jan 2025greater than 30%
Reported reduction in diabetic foot ulcers from temperature monitoringJan 200487.5%
Share of diabetic foot ulcers resulting in amputation (cited)Jan 202510%

Company-reported or press-reported figures, each dated to when it was claimed — not independently audited.

Related companies · 2

Companies working in the same space as Siren Care.

▸Research sources · 1

primary sources listed

1 public sources were cited for this profile; the first-party ones are listed here.

Frequently asked questions

What does Siren Care do?
Siren makes temperature-sensing socks with nurse monitoring to detect early signs of diabetic foot injury.
Who founded Siren Care?
Siren Care was founded by Ran Ma, Jie Fu, Henk Jan Scholten in 2016.
Who are Siren Care's investors?
Siren Care's investors include 500 Global, Aloft VC, Beni Venture Capital, DCM Ventures, Flucas Ventures, HCVC, Manta Ray Ventures, Mighty Capital and 5 more.
Where is Siren Care headquartered?
Siren Care is headquartered in San Francisco, US.