Deep Tech Startups

ReOrbit is a space technology company that manufactures satellites and connected systems for national security, serving government and military customers seeking sovereign control of their space infrastructure and data. It offers co-development and knowledge transfer to help countries build national satellite capabilities, supporting clients from concept through deployment.

5 investors

Rezo maps disease networks to find insights into disease biology for drug discovery. The company operates in the biotechnology and drug discovery space.

5 investors

Samara Aerospace designs and builds high-performance satellite platforms featuring the Hummingbird satellite bus, which combines pointing stability, agility, and power generation in a compact form for commercial, civil, and national security missions. The company's core technology integrates control authority into large deployable structures to enable precise maneuverability without sacrificing payload capacity.

5 investors

Scribe is a molecular engineering company developing CRISPR-based genetic therapies to treat cardiometabolic disease and other conditions. The company uses advanced engineering of natural CRISPR systems to create targeted genetic medicines.

5 investors

Sensible Biotechnologies develops a cell-based mRNA design and manufacturing platform that produces pure, low immunogenicity mRNA therapeutics for drug development. The platform addresses limitations of synthetic mRNA by enabling design-based biology approaches.

5 investors

ShennonBio develops immunotherapy technologies using microfluidic engineering, computational biology, and immunology to advance T cell engineering for cancer treatment. The company serves therapeutic development organizations working on cell and gene therapies.

5 investors

Sibylla Biotech develops PPI-FIT, a drug discovery technology that uses quantum physics and mathematical modeling to characterize protein folding pathways at atomic resolution. The company focuses on protein misfolding diseases, particularly prion diseases.

5 investors

Signaloid develops UxHw technology, a compute platform that propagates uncertainty by evaluating a distribution of inputs in a single program execution to produce distribution-based results. It targets stochastic workloads in quantitative finance, AI/ML, robotics, industrial automation, supply chain, and engineering, claiming large speedups over conventional Monte Carlo methods.

5 investors

SiTration develops silicon-based electro-extraction (SEE) and nano-filtration (SNF) technologies that recover metals and critical minerals from mining waste, leachate, and recycled material using electricity and no added chemicals. Its process serves mining, refining, and recycling operators seeking to turn tailings and wastewater into recoverable resources such as rare earth concentrates, copper, and precious metals.

5 investors

Skyroot builds small-satellite launch vehicles, including the Vikram series of rockets that deliver satellites to low Earth and sun-synchronous orbits via dedicated and rideshare launches. Based in India, it launched Vikram-S, the country's first privately developed rocket, in 2022.

5 investors

Smallest AI develops small, efficient multi-modal voice AI models, including text-to-speech, speech-to-text, and a sub-3B language model, along with an agentic platform for building and deploying voice agents. It offers production-grade audio models and developer tools aimed at enterprises building real-time voice applications.

5 investors

Solestial develops and manufactures radiation-hardened silicon solar power modules for satellites and space applications. The company serves commercial and government customers requiring power solutions for large satellite constellations and space infrastructure.

5 investors

SonoThera is developing a nonviral, non-invasive gene delivery technology that uses ultrasound and microbubbles (ultrasound-mediated delivery) to deliver genetic payloads to targeted sites in a redosable way. The company works on genetic medicine, aiming to address limitations in delivery, safety, durability, and cost.

5 investors

SOSV is a deep tech venture capital firm that makes pre-seed investments (up to $550k) in about 60 startups per year and joins follow-on rounds, backing founders in biotech, therapeutics, climate, energy, and physical AI. It operates labs and offices in San Francisco, New York City, and Newark, with additional teams in India, China, and the EU.

5 investors

Spacebackend builds software infrastructure for integrating multi-vendor aerospace and defense hardware systems, automating the translation of hardware specifications into flight-ready software to collapse integration timelines. The company serves aerospace, defense, and space companies seeking to accelerate the integration and deployment of complex mission-critical systems.

5 investors

SpinDrive develops active magnetic bearing (AMB) technology and provides services spanning client-specific AMB system design, parts supply, and commissioning for manufacturers of high-speed machines. It offers a flexible engagement model and proprietary design software, serving customers across industries as an independent AMB service provider.

5 investors

SpinLaunch develops a kinetic orbital launch system that uses a rotating accelerator to propel satellites into space at ultra-high speeds, reducing fuel and structural requirements compared to traditional rockets. The company targets enterprise customers seeking cost-effective satellite deployment and broadband connectivity services.

5 investors

Stämm develops a high-throughput bioprocessor for biomanufacturing, offering hardware for biologics production in research-use settings. It serves research and biopharmaceutical teams working on biologics.

5 investors

Steady Energy develops the LDR-50, a low-temperature heat reactor based on technology from the Technical Research Centre of Finland. The company commercializes this reactor technology for industrial and environmental applications.

5 investors

Step Pharma develops dencatistat (STP938), a first-in-class, orally bioavailable CTPS1 inhibitor in clinical development as a targeted oncology therapy for blood cancers such as lymphoma and essential thrombocythaemia as well as solid tumours including ovarian cancer. The company focuses on CTPS1 inhibition for cancer treatment.

5 investors

SWIR Vision Systems designs shortwave infrared (SWIR) cameras and sensors based on colloidal quantum dot (CQD) thin-film photodiodes fabricated on silicon readout wafers. Its Acuros CQD imaging products serve applications such as silicon inspection, laser beam profiling, machine vision, surveillance, and autonomous vehicle imaging.

5 investors

Synchron develops brain-computer interface technology delivered via catheter to restore or improve motor and cognitive function in people with impairment or decline. The company serves patients with motor impairment and cognitive decline using a minimally invasive approach inspired by cardiac interventional procedures.

5 investors

Transfr provides career awareness, exploration, preparation, and training programs to help learners discover and transition into in-demand jobs. The company connects organizations and employers to deliver hands-on, immersive career pathways for youth and adults seeking alternatives to traditional four-year college routes.

5 investors

Tynt develops a patented Reversible Metal Electrodeposition (RME) platform for dynamic dimming and smart tinting of transparent surfaces, ranging from smart eyewear to building facades. The technology enables tunable light transmission, blackout, and switchable mirror functions for adaptive hardware applications.

5 investors