Deep Tech Startups

Quaise Energy develops ultra-deep geothermal drilling using gyrotron-powered millimeter-wave technology to reach depths up to 20 km and temperatures up to 500°C, aiming to build superhot geothermal power plants. The company repurposes existing oil and gas workforce, infrastructure, and supply chains to produce clean geothermal energy at scale.</parameter> <parameter name="founders">[]

7 investors

QD-ST develops quantum sensing microscopy systems for semiconductor failure analysis and defect localization in integrated circuits. The company serves R&D and manufacturing teams in the semiconductor industry with non-destructive imaging and metrology tools.

7 investors

Renaissance Fusion develops fusion energy technology in Grenoble, France, focusing on high-temperature superconductors and liquid metal technologies to create clean, abundant energy. The company works to address climate change and sustainable development goals through innovations in fusion reactor design.

7 investors

Reverie Labs built machine learning software for pharmaceutical companies and later developed its own drug pipeline using those ML tools. The company was acquired by Ginkgo in February 2024.

7 investors

Robust.AI develops AI and robotics technology with a focus on human-centered design. The company builds expertise in artificial intelligence, robotics systems, and human-robot interaction.

7 investors

Roebling provides integrated software for capital project teams to connect process models, cost estimates, and business cases in a single system. The platform enables teams to test assumptions and scenarios without rebuilding spreadsheets, serving engineering and project finance teams in capital-intensive industries.

7 investors

Ruby Bio develops biosynthesis technology and scale-up solutions for specialty chemicals, biofuels, and alternative proteins. The company serves manufacturers and food producers seeking sustainable, bio-derived alternatives to traditional chemical and protein sources.

7 investors

Salt OS builds a platform for deploying and managing AI solutions on-premises for regulated enterprises, emphasizing data sovereignty and maintainability of AI workflows.

7 investors

SciRhom is a biotech company developing first-in-class humanized antibodies against iRhom2, which regulates the enzyme TACE/ADAM17 to block pro-inflammatory signaling pathways. Its pipeline targets autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, and lupus nephritis.

7 investors

Seneca develops autonomous drone systems that use AI and computer vision to detect and suppress fires, deploying aerial foam suppression from portable, modular electric copters. Its systems are aimed at fire agencies, utilities, and property owners for fire prevention, early response, structure protection, and hazmat situations.

7 investors

ShennonBio develops immunotherapy technologies using microfluidic engineering, computational biology, and immunology to advance T cell engineering for cancer treatment. The company serves therapeutic development organizations working on cell and gene therapies.

7 investors

Sibylla Biotech develops PPI-FIT, a drug discovery technology that uses quantum physics and mathematical modeling to characterize protein folding pathways at atomic resolution. The company focuses on protein misfolding diseases, particularly prion diseases.

7 investors

Silimate builds AI-powered EDA software that accelerates chip design workflows by combining fast computation engines, machine learning models, and user-friendly interfaces. The platform serves SoC and IP companies in hardware design by functioning as a copilot to help chip designers understand design tradeoffs and iterate faster.

7 investors

SimScale provides a cloud-based simulation platform that combines computational fluid dynamics, finite element analysis, thermal, and electromagnetics capabilities with AI-powered tools for engineers. The platform enables engineering teams to rapidly test design options and make decisions without requiring specialized CAE expertise or dedicated hardware.

7 investors

Sirona builds Direct Air Capture (DAC) machines that remove CO₂ from the atmosphere and store it permanently in rock formations or deep saline aquifers, selling the resulting carbon removal credits. The company sites its operations in regions with abundant underused clean energy such as geothermal and hydro, and targets both the voluntary carbon market today and future compliance markets.

7 investors

Skyroot builds advanced launch vehicles and rocket engines to provide satellite operators with lower-cost, faster access to space. Founded in 2018 and based in Hyderabad, India, it developed the Vikram line of rockets and launched India's first privately built rocket.

7 investors

SOSV is a venture capital firm that provides pre-seed funding (up to $550,000) to founders in deep technology sectors including life sciences, robotics, industrial automation, energy transition, and medical technology. The firm operates accelerator programs in New York City, San Francisco, and Newark, NJ, and does not invest in enterprise software, fintech, blockchain, crypto, cybersecurity, or ecommerce.

7 investors

Spaceium builds in-orbit refueling stations that store fuel and supply it to spacecraft, aiming to enable longer missions, larger payloads, and farther travel. The company operates in the space infrastructure sector.

7 investors

SpinLaunch develops a kinetic orbital launch system that uses a rotating accelerator to propel satellites into space at ultra-high speeds, reducing fuel and structural requirements compared to traditional rockets. The company targets enterprise customers seeking cost-effective satellite deployment and broadband connectivity services.

7 investors

SpliceBio develops genetic medicines using a proprietary protein splicing platform to treat diseases caused by mutations in large genes. The company is currently in clinical stages, with its lead program targeting Stargardt Disease.

7 investors

Stanhope AI develops a Free Energy Minimizing (FEM) world model, an AI architecture for autonomous machines that controls behavior, enables mission planning, and supports human-machine teaming. The company demonstrated the model in drones capable of describing their own reasoning and decision-making across real-world missions.

7 investors

Strateos develops remote access laboratory software and automation platforms that enable scientists to design, execute, and analyze experiments through cloud-based robotics and control systems. The company serves life science researchers globally seeking more efficient and reproducible research capabilities.

7 investors

Surf Therapeutics develops a non-invasive broad-beam ultrasound platform that stimulates nerves to activate the body's cholinergic anti-inflammatory pathway, aiming to restore immune balance and treat inflammatory and autoimmune disorders without drugs. The technology is designed for at-home use to manage chronic inflammation.

7 investors

Switch Therapeutics develops RNA interference (RNAi) therapeutic applications targeting central nervous system diseases, leveraging research from Caltech, Harvard Medical School, and City of Hope.

7 investors