Deep Tech Startups

Sigma Genetics is a biotechnology company developing devices that use magnetic fields to deliver DNA, RNA, and other charged molecules into cells as an alternative to conventional electroporation. The platform technology targets applications including cell therapies, cancer drug delivery, DNA vaccines, biopharma manufacturing, and cosmetics.

3 investors

Signapse builds AI-powered sign language translation technology that generates signed interpretations for video and other content, aiming to make communication accessible to d/Deaf communities. It serves businesses and organisations seeking to provide sign language accessibility, with a stated UK focus and partnerships.

3 investors

Silence Laboratories develops privacy-preserving computation technology, with a team drawing on cryptography, academic, and industry expertise. It operates R&D centers and contributors distributed across multiple countries.

3 investors

Silvec develops RNA-based therapies to protect trees, vines, and bushes from viral, bacterial, and fungal diseases without modifying the host genome. Its treatments use a proprietary type of RNA and are aimed at agricultural and horticultural crops such as citrus, olive, cacao, and banana trees.

3 investors

Singular Photonics develops digital image sensors based on single-photon avalanche diode (SPAD) technology, which convert photons directly into digital signals to capture depth and temporal data as 4D images. The sensors are designed for time-resolved imaging at very low light levels without analogue signal processing.

3 investors

Sinn Studio is an XR game studio specializing in virtual and mixed reality melee combat, building proprietary tools and single- and multiplayer combat games. It develops titles for VR/MR players and is based in Toronto, Canada.

3 investors

SiriusXT develops the SXT-100 soft X-ray microscope, a laboratory-based imaging system that produces nanometer-resolution 3D images of fully hydrated intact cells. The instrument serves research institutions and biotech companies studying subcellular structures and cellular biology.

3 investors

Sirrus develops chemical building blocks based on patented methylene malonate monomers and oligomeric crosslinkers that polymerize anionically at ambient temperatures. Its technology targets high-performance coatings, adhesives, sealants, binders and other polymer products for chemical industry partners.

3 investors

SiTime develops silicon-based (MEMS) precision timing solutions as an alternative to traditional quartz timing components, with devices used across more than 400 applications. It operates in the semiconductor and timing hardware industry.

3 investors

Sixfold Bioscience develops patented drug delivery systems for RNA therapeutics, including siRNAs for gene silencing and mRNAs for gene expression. The company works on commercialising these delivery technologies in the gene therapy and nanomedicine space.

3 investors

Skeletalis is developing OASIS, a targeted small-molecule platform for musculoskeletal and bone health that concentrates therapy at sites of active bone loss while preserving the body's natural bone remodeling. The company translates bone biology research into therapies designed to protect and rebuild bone.

3 investors

SkymatiX provides cloud-based remote sensing and drone surveying services for industries including construction, agriculture, and infrastructure. The company develops and sells software platforms that analyze satellite imagery, drone data, and geospatial information to solve operational challenges.

3 investors

Kyocera-SLD Laser develops laser-based technologies for applications including high-speed communications, sensing, and AR/VR.

3 investors

Snap Fusion is developing a semiconductor-scale approach to nuclear fusion, aiming to make clean fusion power a manufacturable technology through precision control of matter, starting with physics and simulation before building physical proof. The company operates in the fusion energy and deeptech space.

3 investors

SNOW produces lab-grown diamonds using atomic-level crafting methods. The site presents the diamonds as a manufactured product available for wholesale purchase.

3 investors

Softdrive builds Softstream, remote desktop streaming software that lets users connect to any device remotely with low-latency, high-definition performance. It targets enterprise and high-performance use cases such as CAD, medical imaging, geospatial analysis, and media production, transmitting only pixel data with TLS/SRTP AES 256-bit encryption for security.

3 investors

SOLA Biosciences is a preclinical-stage biopharmaceutical company developing gene therapies for neurodegenerative diseases like ALS, Huntington's Disease, and Alzheimer's Disease by targeting misfolded proteins. The company uses its proprietary JUMP70 platform to restore protein homeostasis and deliver disease-modifying treatments.

3 investors

Solinide develops silicon nitride photonics technology for optical interconnect infrastructure with 60%+ efficiency, serving hyperscale datacenters, AI systems, telecommunications networks, quantum computing, and edge computing applications.

3 investors

Solve Therapeutics is a clinical-stage oncology biotech developing antibody-drug conjugates (ADCs) and radiopharmaceuticals for solid tumors, built around its CloakLink hydrophilic cleavable linker platform and an integrated diagnostic for patient selection. The company has two lead programs in Phase 1 clinical development.

3 investors

ADAR One is an ultrasonic 3D sensing system for industrial automation and robotic safety that detects people and objects in complete 180×180° sensing volumes at distances up to 4 metres, operating reliably in conditions where cameras and LiDAR struggle. Designed for autonomous robots in warehouses, factories, logistics, and manufacturing environments, it provides certified safety perception (SIL2/PLd) for human-robot collaboration and machinery hazard detection.

3 investors

Sorex Sensors develops film bulk acoustic resonator (FBAR) technology for sensor applications in semiconductor markets. The company leverages deep expertise in semiconductor design and sensor commercialization to deliver technology-based solutions.

3 investors

Soul Machines develops "Experiential AI" technology to create lifelike, human-like Digital Workers that can see, hear, react, remember and respond emotionally, using cognitive modeling and a patented Digital Brain. Its Digital Workforce product orchestrates across AI systems such as LLMs, autonomous agents, workflows and private data sources to deliver personalized interactions for businesses.

3 investors

SpaceCadet Ventures is a marketing and growth-support firm that works with founders of science- and technology-driven startups, offering story sprints to develop vision, decks, and growth, along with partner support in design, PR, and community.

3 investors

SpaceRyde builds a space cargo transportation system that uses a stratospheric balloon to launch a reusable, multi-functional rocket, aiming to reduce emissions from reaching orbit. After an initial mission the vehicle stays in orbit as part of a rocket network for tasks such as refuelling, deep space missions, and space junk removal.

3 investors