Deep Tech Startups

Root Ventures is a San Francisco-based seed-stage venture fund that leads initial funding rounds for deep tech founders, with typical first checks of $3–5M. Run by engineers, it invests in companies across hardware, robotics, developer tools, AI/ML, and industrial technology.

3 investors

RyboDyn develops breakthrough immunotherapies by identifying and targeting previously hidden disease markers through its proprietary RyboCypher™ technology platform. The company serves patients in need of next-generation treatments for diseases associated with cryptic biological targets.

3 investors

Rypplzz builds a 3D positioning infrastructure, described as a spatial intelligence layer, that runs across telecom networks to turn physical space into a programmable layer for coordination and automation. It works with telecom operators, carriers, and government agencies.

3 investors

S32 is a venture capital firm that invests in technology founders and companies, with particular focus on deep tech, AI, healthcare, and enterprise software. The firm's partners bring operational and scientific expertise from building companies at Alphabet, healthcare organizations, and other major technology ventures.

3 investors

Safe Intelligence provides a software platform, tooling, and services that use formal verification, testing, and robust learning to validate and harden machine learning models such as neural networks and tree ensembles. Its offering targets ML/MLOps teams seeking more reliable, robust models, with deployment locally or via private/single-tenant cloud and API-based pipeline integration.

3 investors

SafeTraces develops technology to measure and verify indoor air quality and ventilation performance, aimed at ensuring air safety in indoor environments. The company applies scientific methods to assess and improve air quality standards for building and facility safety.

3 investors

Sage Geosystems develops pressure geothermal technology to generate energy from the earth's subsurface heat, drawing on decades of experience drilling wells worldwide. The company operates in the geothermal energy sector, aiming to provide sustainable power generation.

3 investors

Salem Robotics develops autonomy software for robotic radiological surveys and inspections in nuclear and hazardous environments. The platform automates route planning, radiation measurement collection, and compliance reporting on existing robot hardware to reduce worker exposure and improve data consistency.

3 investors

Samp builds AI-powered software that generates an always-up-to-date 3D virtual replica of industrial sites from 3D scans, helping teams prepare and execute maintenance, modernisation, and modifications faster. It serves industrial facilities such as those in the water and energy sectors, supporting engineering-to-operations handover and asset visibility.

3 investors

Sand.ai develops video generation models and tools that enable content creation with minimal barriers and cost. The company serves creators and enthusiasts seeking to produce video content efficiently.

3 investors

Sawback Technologies develops remote sensing and machine learning tools to collect, visualize, and analyze near-surface data while reducing environmental impact. It serves the near-surface industry, including oil/gas, construction, and remediation sectors.

3 investors

Scala develops computational protein stability design technology that enables bacterial production of complex human enzymes, applied here to redesign human acetylcholinesterase (AChE) for high-yield, active expression in E. coli. The company's approach supports structural biology, enzyme engineering, and therapeutic and biodefense development in the biotechnology sector.

3 investors

Scentian Bio combines synthetic biology and AI to develop biosensors based on synthesized insect odorant receptors, creating a digital sense of smell and taste that can detect and measure the concentration of thousands of compounds. Spun out of Plant & Food Research, the company holds patents around its odorant-receptor biosensing technology.

3 investors

Scrona is an ETH Zurich spin-off developing a MEMS-based electrohydrodynamic (EHD) inkjet printing platform for micro-manufacturing, enabling sub-micrometer-precision printing on various materials at scale. Its technology targets the manufacturing of semiconductors, displays, PCBs, and advanced micro electronic devices.

3 investors

SecuLetter is a content security company that protects against malware and threats hidden in files and documents, serving public sector, financial, and defense customers. The KOSDAQ-listed cybersecurity firm is expanding its content security category since its 2023 listing.

3 investors

Seer develops proteomics tools for large-scale protein analysis, including an assay, automation instrument, and analysis software for studying the proteome across human and non-human samples. Its products serve researchers running deep, reproducible proteomic studies at scale.

3 investors

Seismos provides an AI intelligence layer that converts acoustic signals and sensor measurements into real-time completion decisions for oil and gas well operators. Built on a database of perforation efficiency and uniformity measurements across thousands of wells, its physics-based platform delivers recommendations to optimize field operations and enable autonomous control.

3 investors

SemiQon designs and fabricates semiconductor-based quantum processing units (chips) intended to make quantum computers more compact and affordable. The company focuses on chip design, fabrication, and measurement, drawing on quantum and microelectronics research within the European and global quantum industry.

3 investors

Sorrento Therapeutics is a biotechnology and life sciences company that develops therapeutics and technologies through in-house programs, acquisitions, and mergers. Its portfolio spans areas including antibody-drug conjugates, cell therapy, and lymphatic drug delivery systems.

3 investors

Sensome develops medical technology solutions at the intersection of engineering and life sciences, focusing on healthcare applications.

3 investors

ShapeTX develops programmable RNA medicines by combining artificial intelligence with RNA technology to address genetic causes of disease.

3 investors

Shift Thermal develops thermal storage technology for data center cooling systems, enabling efficient power allocation between cooling and computing infrastructure.

3 investors

Shone develops retrofit technology that adds autonomous capabilities to existing cargo ships, serving the maritime shipping and logistics industry.

3 investors

Si-Ware Systems develops sensing technologies combining MEMS, optical components, embedded processing, and AI to create sensing solutions for industrial and scientific applications. The company offers OEM components, standalone devices, and sensor management software serving customers across multiple industries.

3 investors