Deep Tech Startups

Sphere is device-agnostic XR (augmented/mixed reality) software for spatial collaboration, enabling enterprise teams to collaborate remotely, train frontline workers with hands-free guidance, run immersive sales demos, and simulate construction and manufacturing processes. It serves enterprises across industries such as manufacturing, construction, and healthcare/telemedicine.

2 investors

Spirea develops a multivalent ADC linker technology called ELIVATE that expands the range of usable payloads for antibody-drug conjugates, aiming to enable next-generation ADCs for oncology, inflammation, and autoimmune diseases. The company develops proprietary linker-payloads and offers ADC design and conjugation expertise for partnering with pharmaceutical and biotech companies.

2 investors

spotLESS Materials develops nature-inspired liquid-entrenched smooth surface (LESS) coatings that repel liquids, sludge, and contaminants while enabling self-cleaning properties for industrial applications including sanitation, automotive, and medical sectors.

2 investors

StairMed develops invasive brain-computer interface technology, including ultra-flexible micro-nano electrodes, an implantation-assist device, an implantation surgical robot, and a high-throughput neural signal acquisition system. Its products target neuroscience research and clinical applications addressing conditions such as paralysis, aphasia, blindness, and deafness.

2 investors

Starling Systems designs and builds fixed-wing VTOL drones with over three hours of flight endurance, along with a portable ground station ("Starling Hub") that supports rapid battery replacement, precision QR-code landing, onboard cameras/sensors, and optional cellular and satellite communication. The products are designed and built in California and aimed at professional drone operators.

2 investors

SSNF develops precision nanoscale manufacturing equipment using projection-based two-photon polymerization for high-throughput fabrication of complex sub-micron structures. The company targets inertial confinement fusion energy applications and aims to enable industrial-scale production of fusion capsules.

2 investors

Stellaria develops an advanced molten salt reactor (AMR-MSR), the Stellarium, a fast-neutron liquid-core nuclear reactor that renews 100% of its fuel during operation and burns long-lived high-activity waste. It targets industrial sites such as petrochemical plants, mines, and datacenters, providing decarbonized electricity, e-fuels, and high-temperature steam.

2 investors

Stimdia Medical develops neuromodulation technologies, with a leadership team focused on clinical and regulatory affairs and R&D in critical care and pulmonary medicine. The company operates in the medical device sector.

2 investors

StimOxyGen develops a pH-sensitive polymer-coated nanoparticle formulation that dissolves in low-pH environments and transiently generates oxygen within hypoxic solid tumours to improve the efficacy of cancer treatments such as radiotherapy and chemotherapy. The nanoparticle can also carry additional therapeutic payloads on its polymer coating.

2 investors

Stralis develops hydrogen-electric aircraft for long-range passenger and cargo delivery applications. The company is designing aircraft that combine hydrogen fuel cells with electric propulsion for aviation.

2 investors

Street Smarts builds virtual reality simulation, content, and data systems for standards-based weapons and readiness training, letting military and uniformed units run repeatable, measurable training without range time, ammunition, or on-site instructors. It serves defense and uniformed service organizations across North America.

2 investors

String Bio develops products using a synthetic biology and gas fermentation platform combining chemistry, process engineering and fermentation, serving customers in nutrition, agriculture and personal care. The India-based company scales its technology from lab to commercial production of target products.

2 investors

NeuraNova (formerly StrokeDx) develops non-invasive neurovascular diagnostic technology aimed at rapid detection for stroke and brain-related conditions. Its product is not yet FDA cleared or commercially available.

2 investors

Studio 3e8 builds a desktop metal 3D printing system with an integrated hardware, software, and materials platform that runs on a standard outlet. The company targets designers and fabrication users, aiming to lower the cost and complexity of professional-grade metal additive manufacturing.

2 investors

subdron builds autonomous underwater inspection technology with proprietary relative-object navigation (RON) that works in zero-visibility, confined environments and integrates with any AUV or ROV. It serves port authorities, fleet operators, naval commands and engineering firms across Europe to inspect and protect subsea infrastructure such as cables, pipelines and energy assets.

2 investors

SunDrive is a solar technology company developing methods to lower the cost of high-efficiency solar cells while improving their performance and sustainability by using more abundant materials. It builds unique chemistries (photoresist, pretreatment, plating) alongside equipment design and automation to scale novel processes into industrial solar cell production.

2 investors

Sunthetics develops machine learning algorithms and software for chemical engineering applications. The company serves industrial and R&D teams in the chemical and materials sectors.

2 investors

SuperCom is a secure solutions integrator and technology provider offering biometric identification and cyber security systems for governments and other consumer-facing organizations. The company deploys end-to-end secured digital identity solutions internationally across multiple countries and continents.

2 investors

Surf Bio is a preclinical biopharmaceutical company developing its SnapShot technology, which uses a proprietary polymer to create ultra-high-concentration antibody and biologic formulations (600+ mg/mL, doses over 1,000 mg) for delivery via a standard autoinjector. The technology enables at-home subcutaneous self-injection of monoclonal antibodies and biologics as an alternative to in-clinic IV infusion, and is offered to pharmaceutical API manufacturers through partnerships.

2 investors

Surrey Nanosystems develops and manufactures Vantablack, an advanced nanomaterial coating that absorbs up to 99.965% of light, used to eliminate stray light and reflections. The coating serves aerospace, automotive, optics, and design industries.

2 investors

Sweetch Energy develops INOD nanotechnology to convert osmotic energy — the salinity difference between fresh and saltwater — into continuous carbon-free electricity. Its technology targets applications such as grid-scale renewable power, off-grid coastal communities, desalination and wastewater plants, and industrial sites with saline effluents.

2 investors

SymbolicMind develops CPU-native AI that uses symbolic rather than matrix computation to reduce training and inference energy consumption and costs by over 100x in reasoning workloads. It targets chipmakers, server manufacturers, and data centers seeking higher AI density and lower power and cooling requirements without custom accelerators.

2 investors

Synaffix develops antibody-drug conjugate (ADC) technology, providing linker-payload platforms that attach small-molecule, peptide, and protein-based payloads to antibodies for use in targeted cancer therapies. The company has been integrated into Lonza's Advanced Synthesis business platform.

2 investors

SYNthesis med chem is a global contract research organization providing small molecule drug discovery services, combining medicinal chemistry expertise with synthetic chemistry resources. It supports biotech and pharma clients across programs from hit discovery through lead optimisation to clinical candidate nomination, including emerging modalities such as PROTACs, molecular glues and ADCs.

2 investors