Deep Tech Startups

SparingVision develops neuroprotective gene therapies for rare genetic diseases affecting the eye and nervous system. The company's lead candidate, SPVN06, is being evaluated in the PRODYGY clinical trial.

3 investors

SparkNano designs and commercializes spatial Atomic Layer Deposition (ALD) tools for industrial-scale nanofabrication, enabling manufacturers to deposit ultra-thin functional layers while improving performance and reducing costs for fuel cells, batteries, and solar cells. The company serves energy and advanced electronics manufacturers seeking to optimize material efficiency and reduce supply chain waste.

3 investors

Spectra Plasmonics develops chemical analysis technology that detects chemicals for organizations across government, clean technology, and other industries requiring actionable chemical insights.

3 investors

Spectral Labs builds foundation models with spatial intelligence to design and reason about physical systems for engineering and manufacturing applications.

3 investors

SpectraWAVE develops optical and computational imaging technologies to diagnose and guide treatment decisions for patients with coronary artery disease and cardiovascular disease. The company operates vertically integrated design, manufacturing, and commercialization operations for its medical devices.

3 investors

Spectrohm develops radio-wave imaging technology that simultaneously images the interior of objects and identifies their material composition while they move on high-speed conveyors. The system is aimed at automated, high-throughput inspection, combining machine vision with AI to distinguish materials such as different liquids.

3 investors

Sphere develops unified augmented reality software that integrates with enterprise systems like CRM, ERP, and LMS platforms. The platform supports 60+ file types and works across AR headsets, VR devices, smartphones, tablets, and PCs for organizations needing XR deployment at scale.

3 investors

SphingoTec develops proprietary biomarkers for critical care diagnostics, addressing acute kidney injury, sepsis, and acute heart failure through partnerships with in vitro diagnostics companies and pharmaceutical firms. The company licenses its biomarker portfolio to global IVD partners to make clinical diagnostic products available worldwide.

3 investors

Spirea develops a multivalent ADC linker technology called ELIVATE that expands the range of usable payloads for antibody-drug conjugates, aiming to enable next-generation ADCs for oncology, inflammation, and autoimmune diseases. The company develops proprietary linker-payloads and offers ADC design and conjugation expertise for partnering with pharmaceutical and biotech companies.

3 investors

Spora discovers and cultivates wild fungal strains from pristine ecosystems, processing them with proprietary biotechnology and nanotechnology to create mycelium-based products. The company combines scientific research with ancestral knowledge from remote communities to develop sustainable, nature-inspired solutions.

3 investors

Spotless Materials develops PFAS-free repellent coatings that reduce surface fouling and contamination on glass, metal, ceramic, and plastic surfaces. Initially launched as a consumer product, the coatings are now used in industrial applications including medical devices, diagnostic equipment, and automotive components.

3 investors

Spraywerx supplies industrial coating equipment, including HVOF and plasma thermal spray systems, laser cladding systems, powder feeders, and coating powders. It serves industrial coating providers needing tools for wear- and corrosion-resistant coatings.

3 investors

Staex builds a secure autonomous agent platform for connected devices and machines, enabling cryptographically verified data exchange and autonomous transactions across IoT ecosystems. The technology is designed for industrial applications, mobility, and the emerging machine economy.

3 investors

Standard Machines is building reinforcement learning environments for long-horizon chip design tasks. Its first product targets the semiconductor design workflow using RL-based methods.

3 investors

Stark Defence describes itself as a defense company emphasizing speed of assembly and investing over 45% of its expenditure into R&D to convert innovation into capability.

3 investors

Stateful builds a decision intelligence engine that turns operational requirements into optimised, adaptive missions for mobile robots, coordinating single-robot, multi-robot, and human-robot operations across changing real-world environments. A spin-out from the University of Oxford, it serves robotics operators across sectors including energy, marine, defence, warehousing, mining, construction, agriculture, healthcare, and logistics.

3 investors

Steinmetz designs and manufactures high-voltage motor controllers and traction inverters for electric vehicles, industrial automation, and robotics. The company produces power electronics with industry-leading power density and efficiency for EV drivetrains and motor control systems.

3 investors

SSNF develops precision nanoscale manufacturing equipment using projection-based two-photon polymerization for high-throughput fabrication of complex sub-micron structures. The company targets inertial confinement fusion energy applications and aims to enable industrial-scale production of fusion capsules.

3 investors

Strand AI predicts missing biological data modalities from existing patient data, converting single histopathology slides into spatial protein maps and inferring gene expression from genotype. The platform serves researchers and clinicians in computational pathology and genomics.

3 investors

Street Smarts builds virtual reality simulation, content, and data systems for standards-based weapons and readiness training, letting military and uniformed units run repeatable, measurable training without range time, ammunition, or on-site instructors. It serves defense and uniformed service organizations across North America.

3 investors

String Bio develops technology at the intersection of biology, engineering, and chemistry to produce next-generation ingredients addressing challenges in food, feed, health, and the environment. The company operates a proprietary technology platform and a product portfolio aimed at sustainable and scalable bio-based solutions.

3 investors

Striveworks builds AI-powered automatic target recognition (ATR) software that detects, classifies, and tracks objects across sensor types ranging from overhead satellite imagery to low-angle drone feeds, using dynamic model routing to maintain target custody. Its technology is aimed at defense and intelligence surveillance applications.

3 investors

Substrate is developing a U.S.-based semiconductor foundry, inventing technology aimed at extending Moore's Law while lowering the cost of leading-edge fabs and the wafers they produce.

3 investors

SunDrive is a solar technology company developing methods to lower the cost of high-efficiency solar cells while improving their performance and sustainability by using more abundant materials. It builds unique chemistries (photoresist, pretreatment, plating) alongside equipment design and automation to scale novel processes into industrial solar cell production.

3 investors