Longevity Startups

System Labs sells premium peptide treatments sourced from licensed U.S. pharmacies, pairing customers with a licensed clinician who guides them through treatment via an online intake flow. Its products, such as NAD+ and glutathione, are aimed at supporting performance and longevity, with medications compounded by certified U.S. pharmacies.

3 investors

The Akkermansia Company produces a consumer dietary supplement containing proprietary Akkermansia MucT™ bacteria formulated to support weight management, glucose metabolism, gut health, and immune function.

3 investors

Total Life provides online therapy delivered by licensed therapists specializing in late-life mental health, available to adults 65 and older through Medicare coverage.

3 investors

Cogent Biosciences is a biotechnology company developing small molecule precision therapies for genetically driven diseases where the cause is linked to a specific genetic mutation. It runs a discovery organization in Boulder, Colorado, aiming to create treatments for patients with unmet medical needs.

3 investors

Vandria is a pharmaceutical development company focused on translating scientific innovation into first-in-class therapeutics. The company's management team specializes in mitochondrial function and neurological disease treatment.

3 investors

Vasa Therapeutics is a biopharmaceutical company focused on discovering and developing therapeutics that target the pathophysiology of cardiovascular aging. It operates from locations in California and Poland.

3 investors

Yuva Biosciences develops and licenses Y100, a cosmetic active ingredient that enhances mitochondrial health to reduce visible signs of aging for use in skincare and haircare products.

3 investors

AgeWellJapan creates services and spaces that connect seniors with younger generations and bridge communities of residents, researchers, and business stakeholders around the concept of aging positively through challenge and discovery. The company positions itself as a "life companion" for elderly people, supporting active lifestyles and social engagement in Japan's super-aging society.

3 investors

Reprocell is a biotechnology company that manufactures and sells iPS cell-related research reagents, provides drug discovery support services including iPS cell establishment and CRO services, and offers clinical testing and regenerative medicine product development.

2 investors

Accuitis is developing a lead drug compound that restores mitochondrial SIRT3 expression to recover healthy cellular function, targeting neurodegenerative diseases including Alzheimer's, Parkinson's, and methamphetamine addiction. Its work is in preclinical research and development.

2 investors

Acumen Pharmaceuticals is developing treatments for Alzheimer's disease and other neurodegenerative diseases, focusing on understanding and targeting amyloid beta oligomers in neurodegeneration.

2 investors

AcuraStem is a biotechnology company developing antisense oligonucleotide treatments for neurodegenerative diseases such as ALS and frontotemporal dementia, using its iNeuroRx technology platform for disease modeling and drug discovery. It targets PIKFYVE, discovered by its co-founders, to advance a pipeline of therapies.

2 investors

AdipoPharma is a biotech company developing therapies based on the endocrine biology of adipose tissue and targeted rare genetic disorders. Founded in 2022 (formerly ALMS Therapeutics), its work relates to metabolic diseases such as diabetes and obesity.

2 investors

Ahead Health provides preventive health check-ups combining whole-body MRI scans and blood tests (80+ biomarkers) reviewed by Swiss doctors using AI-assisted diagnostics, delivering personalized health reports and recommendations. It offers a membership model with clinic partners for consumers in Switzerland seeking early detection and long-term health monitoring.

2 investors

Akribion Therapeutics develops an RNA-guided, nuclease enzyme-based technology for programmable cell depletion using its G-dase E payload. The company initially targets HPV-induced oropharyngeal head and neck cancer (OPSCC) and is exploring further applications in precision oncology.

2 investors

A senior care consulting firm serving Greater Boston families since 1993, offering life care management and aging support services with clinical expertise in geriatric social work.

2 investors

Alpha-9 is a clinical-stage radiopharmaceutical company developing a portfolio of targeted molecules to treat cancer cells with precision. It operates in the oncology and precision medicine space.

2 investors

Amyriad Therapeutics develops disease-modifying therapies for Alzheimer's disease, with a lead candidate called Ismidenon that employs novel cholinergic enhancement mechanisms. The company is led by neuroscientists and clinical experts focused on restoring cognitive function in aging-related neurodegeneration.

2 investors

ANI.AI is a San Francisco research lab building a computational platform for longevity medicine that integrates deep multiomics, longitudinal digital phenotyping, and physician-supervised intervention into a unified model of an individual's biological state. It runs the ELITE healthspan intervention trial and an intervention layer (AgeBiotics) to make individual response to aging interventions measurable, working with research groups and clinical teams studying aging, cognition, muscle, immunity, metabolism, and microbiome.

2 investors

APstem develops regenerative medicine therapies based on the activation of dormant pluripotent cells found in adult blood, with an initial focus on treating Type 1 Diabetes and other currently incurable diseases.

2 investors

Arexera Therapeutics, formerly Atalanta Therapeutics, is a biotechnology company developing small interfering RNA (siRNA) medicines to treat severe neurological diseases, with a franchise focused on Huntington's disease.

2 investors

Arvada Therapeutics is a biotechnology company focused on drug development for rare and degenerative diseases, working across preclinical research and clinical stages. Its work spans biologics development, including areas such as cardiovascular and immunology-related programs.

2 investors

Atria Health and Research Institute provides personalized preventive medicine and longevity services, combining clinical care with research to demonstrate and advance disease prevention strategies. The institute serves individuals and health professionals seeking to prevent chronic disease and enhance healthy lifespan through precision-based approaches across medical specialties.

2 investors

AutoPhagyGO is a biotech company focused on autophagy research with applications in longevity and age-related disease prevention and treatment. The company leverages cellular regeneration mechanisms to develop therapeutics that promote healthy aging.

2 investors