Longevity Startups

LifeX is a venture capital firm led by scientists and serial entrepreneurs who provide strategic guidance to founders on complex business decisions.

3 investors

Lindora provides metabolic health assessments and personalized wellness plans guided by medical frameworks and lab analysis. The company serves individuals seeking to optimize body composition and sustained energy through data-driven, medically supervised recommendations.

3 investors

LUCA Science develops mitochondrial therapies that supply functional, storable mitochondria to damaged or dysfunctional cells and tissues to restore cellular energy production, targeting conditions such as ischemia-reperfusion injuries including cerebral and myocardial infarction. The company works in the biopharmaceutical field, building a platform based on its proprietary iMIT mitochondria technology.

3 investors

Mimio makes a daily supplement built from fasting metabolites that aims to recreate the cellular health and longevity benefits of prolonged fasting without requiring users to fast. The consumer product is positioned around autophagy support, healthy aging, appetite control, and metabolic health.

3 investors

Mitra develops a non-invasive skin diagnostics platform that combines clinical trials, skin sampling, next-generation sequencing, and data science to guide the design of age-rejuvenating skincare compounds. The company applies genomics to skin health and precision dermatological therapies.

3 investors

Nagi Bioscience provides in vivo toxicity testing services using organism-on-chip technology with C. elegans models, serving pharmaceutical, chemical, and biotech companies seeking faster, ethical alternatives to traditional animal testing. The company delivers high-throughput developmental, reproductive, and eco-toxicity assays aligned with regulatory frameworks.

3 investors

Nectome offers a whole-body and whole-brain human preservation method intended to retain every synapse and cell at end of life for potential future revival. The protocol is compatible with traditional funerals at room temperature and remains stable for hundreds of years when stored cold.

3 investors

Oak Street Health operates a network of primary care centers focused on preventive and comprehensive care for older adults, offering personalized wellness plans, integrated health services, and care coordination with specialists. Founded in 2012, it is now part of CVS Health.

3 investors

Oisín Biotechnologies develops non-viral genetic therapies built on its Fusogenix Proteo-Lipid Vehicle (PLV) delivery platform, which delivers DNA and RNA payloads to tissues throughout the body and allows repeat dosing. Its pipeline targets the biology of aging, with programs in targeted fat removal, muscle building, and longevity biology across aesthetic and longevity medicine.

3 investors

Omniscope develops diagnostics and therapeutics technology based on the convergence of AI and immunology, aiming to interpret immune system data to generate therapeutics, develop diagnostics, and monitor patients. Founded in 2020, the company applies machine learning to immunology with a focus on health equity.

3 investors

Opt Health connects patients with medical experts for personalized consultations via telemedicine, providing preventive care guidance and treatment plans delivered online and through an integrated pharmacy service.

3 investors

Pelage develops regenerative medicines for hair loss based on stem cell biology, with a lead candidate (PP405) that is a topical small-molecule drug designed to reactivate dormant hair follicle stem cells. It targets conditions including androgenetic alopecia, drug-induced alopecia, and telogen effluvium, and is currently in clinical trials.

3 investors

Permanence Bio is a biotech company developing therapies aimed at cancer prevention by protecting the genome from damage, drawing on aging and DNA repair research. It works to discover cancer-preventing compounds and advance lead compounds from mechanism of action through IND-enabling studies and into the clinic.

3 investors

Photys Therapeutics develops bifunctional small-molecule medicines that use induced proximity to recruit kinases and drive targeted protein phosphorylation, aiming to modulate and repair disease-driving proteins. It is building a therapeutic pipeline for autoimmune, inflammatory, oncology, and cardiometabolic diseases.

3 investors

Rehab for JAPAN develops and provides "Rehab Cloud," a SaaS platform for elderly care and rehabilitation providers, along with "Rehab Studio," an online rehabilitation service, and conducts R&D on AI-based care technology. The company serves care facilities and elderly-care operators in Japan.

3 investors

Retro Biosciences is a biotechnology company focused on research aimed at extending healthy human lifespan. Its work is carried out by a team of scientists, entrepreneurs, and operators in the longevity space.

3 investors

Revel Pharmaceuticals develops enzyme-based therapeutics designed to recognize and reverse molecular damage that accumulates in the body's structural tissue — collagen, elastin, and extracellular matrix — targeting age-related damage that drives disease. The company screens natural enzyme variants against real substrates to identify and engineer them into treatments.

3 investors

Rona Therapeutics develops siRNA-based therapeutics using its GAIA platform to target metabolic and cardiovascular conditions including hypertriglyceridemia, obesity, ASCVD, and MASH. Its pipeline includes APOC3, INHBE, PCSK9-Lp(a), and angiotensinogen-targeting candidates for patients with cardiovascular and metabolic diseases.

3 investors

Savvly offers an SEC-registered investment vehicle designed for extended retirement spans, providing scheduled cash payouts at ages 80, 85, 90, and 95 through a pooled S&P 500 index fund with longevity-focused reallocation. The product serves individuals planning for retirements lasting 25-30 years and their financial advisors.

3 investors

Sorrento Therapeutics is a biotechnology and life sciences company that develops therapeutics and technologies through in-house programs, acquisitions, and mergers. Its portfolio spans areas including antibody-drug conjugates, cell therapy, and lymphatic drug delivery systems.

3 investors

Serenity Smart provides a software platform for senior living, hospice, home health, and long-term care operators that coordinates messaging and workflows between care staff, families, and older adults. The platform is available on web, mobile, and smart assistant applications and is built to improve operational visibility and reduce staff burden.

3 investors

Shift Bioscience develops siRNA therapeutics for cell rejuvenation, using a target identification platform that has identified an anti-fibrotic candidate initially aimed at liver fibrosis. The company works in the aging and longevity biotech field, having discovered novel aging targets linked to disease states.

3 investors

Sironax is a biopharmaceutical company focused on the discovery and development of therapies for neurodegenerative, inflammatory and immunological, metabolic, and rare diseases. Its research targets conditions affecting longevity, those requiring supportive care, and certain rare diseases.

3 investors

Squared Circles is a consumer health venture studio that partners with scientists and operators to conceive, launch, and scale consumer brands in health and longevity. It focuses on bioscience-grounded products aimed at the consumer wellness market.

3 investors