Longevity Startups

Nucleus provides genetic testing and analysis for couples planning pregnancy, screening for over 200 hereditary diseases, traits, and health conditions. For those undergoing IVF, the company offers embryo selection guidance to reduce disease risk and optimize traits including eye color, height, and intelligence.

5 investors

ONTO Health provides personalized fertility, hormone, and longevity care for patients at various stages of reproductive health, combining evidence-based medicine with diagnostics and wellness therapies. The company offers technology-enabled, human-centered care led by reproductive specialists, serving individuals planning fertility, seeking treatment, or exploring preventive reproductive health options.

5 investors

Samsara Therapeutics develops small-molecule therapeutics that activate autophagy to slow the progression of age-related neurodegenerative diseases such as ALS, Parkinson's, and Charcot-Marie-Tooth disease. It runs an in-house phenotypic screening platform using patient-derived iPSCs to identify and validate autophagy activators for drug discovery.

5 investors

Viome offers at-home tests that analyze the gut and oral microbiome plus cellular blood samples using mRNA/metatranscriptomic sequencing, returning 70+ health scores (including biological age and inflammation) and personalized food and supplement recommendations. The direct-to-consumer service, analyzed in a CLIA-certified lab, is aimed at individuals seeking insights into digestion, metabolism, and overall wellness.

5 investors

Aardvark Therapeutics is a clinical-stage biopharmaceutical company developing small-molecule drugs that inhibit hunger to treat metabolic diseases. Its lead compound, ARD-101, is an oral investigational drug for hunger-associated rare diseases that activates bitter taste receptors in the gut to trigger satiety signals, with potential applications in hyperphagia and obesity.

4 investors

Adipo develops investigational therapeutics that promote weight loss by activating brown fat to increase energy expenditure, offering an alternative to appetite-suppressing drugs like GLP-1s. The company targets people seeking weight management solutions beyond diet and calorie restriction.

4 investors

Affini-T Therapeutics develops TCR-based immunotherapies aimed at treating solid tumors, using two complementary therapeutic modalities. The company operates in the biotech and cancer immunotherapy space.

4 investors

AvenCell Therapeutics develops next-generation cell therapies for hard-to-treat cancers, including solid tumors, combining switchable universal CAR-T technology with a CRISPR/Cas9-based allogeneic platform. The clinical-stage biopharmaceutical company creates autologous and allogeneic reprogrammable T-cell products and operates in both the US and Europe.

4 investors

BIOIO develops a genetics-based platform for elucidating drug mechanisms of action, combining decades of research in pharmacology with big data and automation to accelerate drug discovery and development. The company serves pharmaceutical and biotech organizations seeking to understand how drugs work.

4 investors

BreezeBio develops a programmable platform called NanoGalaxy for targeted delivery of genetic medicines, aiming to move genetic payloads to specific cells and tissues. The company operates in the biotech and genetic therapeutics space.

4 investors

Candoo Tech provides technology support and training services designed for older adults, helping them use devices, software applications, and smart home technology safely and effectively. The company serves seniors and their adult children or caregivers who need assistance with technology adoption and ongoing support.

4 investors

Celularity is a regenerative and cellular medicine company developing and commercializing biomaterial products and allogeneic, cryopreserved cell therapies derived from the postpartum placenta to target age-related diseases. It operates its own integrated manufacturing, translational research, and biobanking facility for placenta-derived cellular medicines and advanced biomaterials.

4 investors

Cenegenics is a physician-led age management and performance health system that uses diagnostics and data-driven interventions to help individuals optimize strength, cognition, metabolic health, and longevity. The company serves individuals seeking personalized, medically grounded approaches to extending peak physical and cognitive performance.

4 investors

Circle provides personalized functional medicine and preventive healthcare, offering consultations, targeted health checks (including at-home gut tests), and treatments such as infusion therapies. It serves individuals seeking structured, proactive health guidance beyond standard short appointments.

4 investors

Cleara Biotech develops compounds to eliminate senescent cells for treating late-stage cancer and chronic age-related diseases. The company translates academic research on cellular senescence into clinical therapeutics.

4 investors

Cumulus Oncology is a drug development company specializing in oncology therapeutics, leveraging experienced leadership with track records in new drug applications and successful M&A transactions. The company builds a risk-adjusted portfolio in the life sciences and pharmaceutical sector.

4 investors

dNovo develops cellular reprogramming technology that converts patient-derived cells (blood, skin, or fat) into other cell types, with an initial focus on generating new hair to treat hair loss. The company, with research origins at Stanford and Harvard, aims to eventually produce cells, tissues, and organs on demand.

4 investors

Edifice Health offers the Inflammatory Age test, a biomarker composite scoring system that measures and monitors a person's inflammatory and immune health for early detection and prevention of chronic disease. The test, derived from Stanford University research using omics platforms and AI, is provided to clinics, physicians, and healthcare providers to help manage patients' chronic inflammation and longevity.

4 investors

Forever Labs collects and cryogenically stores adult stem cells for individuals and develops therapies based on stem cell rejuvenation. The company operates in the longevity and anti-aging biotech space.

4 investors

Gerostate Alpha develops therapeutics aimed at aging and chronic disease. The company operates in the biotech and therapeutics space.

4 investors

Gila Therapeutics is a clinical-stage biotech company developing a topical lingual signaling platform that delivers micro-dose PYY dissolving on the tongue to activate brain regions regulating food intake and metabolism. Its treatments target obesity, type 2 diabetes, and associated cardiometabolic disorders.

4 investors

Hepatx develops regenerative medicine treatments delivered via infusion as an alternative to organ transplants for patients with chronic liver disease. The company focuses on repairing diseased and damaged liver tissue.

4 investors

Lifeforce offers a health membership that measures over 50 biomarkers and provides personalized insights, health tracking, and one-on-one clinician support. It serves consumers looking to monitor and improve their long-term health and physical performance.

4 investors

Livez is an AI-based health platform that combines behavioral science, medical protocols, and in-house doctors to deliver personalized, preventive care aimed at reducing chronic disease before symptoms appear. It targets individuals across all health statuses, ages, and lifestyles with automated preventive health guidance.

4 investors