Longevity Startups

Holobiome discovers and develops therapies derived from the human gut microbiome, working to translate microbiome science into probiotics and targeted treatments for whole-body health. The company was founded by research scientists from Northeastern University.

5 investors

Hone is an online clinic offering telehealth consultations, doctor-prescribed medications, and biomarker testing to help aging men and women manage their health. It provides personalized, proactive care aimed at Americans seeking to improve health and longevity.

5 investors

Jona is a health company focused on gut and microbiome analysis, drawing on gastroenterology and microbiome science to interpret an individual's microbiome for health insights. It is advised by physicians and scientists specializing in gastroenterology, microbiome research, and longevity.

5 investors

Loyal develops longevity drugs for dogs, targeting the biological processes of aging to extend healthy lifespan and reduce age-associated disease. Its lead drug candidate, LOY-002, is a once-daily pill for senior dogs that addresses metabolic dysfunction and is progressing through FDA conditional approval, alongside a broader portfolio of aging therapeutics and educational resources for veterinarians.

5 investors

NodThera develops NLRP3 inflammasome inhibitors, with a clinical-stage pipeline of targeted medicines aimed at cardiometabolic and neuroinflammatory diseases. The company focuses on treating inflammation at its source for patients affected by age-related conditions.

5 investors

OneSkin develops topical skincare products built around OS-01, a proprietary peptide the company says reduces cellular senescence in skin to address visible signs of aging such as wrinkles and hyperpigmentation. It sells science-backed anti-aging skincare directly to consumers, supported by its own peptide and skin-health research.

5 investors

Siphox Health develops early diagnostic testing technology to detect and manage chronic diseases at home, delivered as a painless 5-minute test that enables frequent monitoring. The company targets the U.S. healthcare system to reduce the health and economic burden of chronic disease.

5 investors

Vincere develops therapeutics for age-related diseases such as Parkinson's and kidney disease, using a computational platform that combines human genetics, cellular network models, and in-silico biology to identify drug targets like USP30 for mitochondrial repair. The company is developing small-molecule candidates aimed at human trials and pharma partnerships.

5 investors

Zymeworks is a royalty-driven biotechnology company that develops multifunctional antibody-based therapeutics, including antibody-drug conjugates and multispecific antibodies, for solid tumors and other difficult-to-treat diseases. It manages a portfolio of licensed healthcare assets — including the approved drug Ziihera (zanidatamab) and pasritamig — and partners its therapeutic platforms with biopharmaceutical companies to generate royalty and milestone revenue.

5 investors

AvenCell Therapeutics develops next-generation cell therapies for hard-to-treat cancers, including solid tumors, combining switchable universal CAR-T technology with a CRISPR/Cas9-based allogeneic platform. The clinical-stage biopharmaceutical company creates autologous and allogeneic reprogrammable T-cell products and operates in both the US and Europe.

4 investors

Candoo Tech provides technology support and training services designed for older adults, helping them use devices, software applications, and smart home technology safely and effectively. The company serves seniors and their adult children or caregivers who need assistance with technology adoption and ongoing support.

4 investors

Cenegenics operates a personalized medicine program that measures over 100 biomarkers to establish a health baseline and delivers concierge physician care, diagnostics, and a data-driven plan focused on healthspan and human performance. It serves individuals seeking to improve longevity, metabolism, energy, cognition, and biological age.

4 investors

Curana Health provides on-site primary care and value-based care for senior housing residents, operating Accountable Care Organizations (ACOs) and Medicare Advantage Special Needs Plans. It partners with senior living and skilled nursing operators across the United States to deliver care to seniors in assisted living and similar communities.

4 investors

Edifice Health offers the Inflammatory Age test, a biomarker composite scoring system that measures and monitors a person's inflammatory and immune health for early detection and prevention of chronic disease. The test, derived from Stanford University research using omics platforms and AI, is provided to clinics, physicians, and healthcare providers to help manage patients' chronic inflammation and longevity.

4 investors

Eternal is a personalized health platform that combines wearable data, lab results, and AI coaching to deliver customized podcasts, daily texts, and in-person care for fitness, health, and longevity. The service integrates diagnostics, training, and professional medical oversight for consumers seeking comprehensive health optimization.

4 investors

Everlab is a health platform offering preventative diagnostics, longevity testing (bloodwork, genetics, and fitness), and access to longevity-trained doctors, dietitians, and physios, with results and care plans tracked in a single app. It serves individual consumers seeking proactive and preventative healthcare across Australia.

4 investors

EXCIVA is a privately held biotech company developing clinical-stage therapeutics for neuropsychiatric indications, with a focus on treating neuropsychiatric symptoms of dementia such as agitation and aggression in Alzheimer's disease. Its lead candidate, Deraphan, is in Phase 2/3 trials.

4 investors

Ezra offers advanced MRI-based full-body scans designed to screen for early signs of cancer and hundreds of other medical conditions. The service targets individuals seeking preventive health screening, with scans potentially eligible for HSA/FSA reimbursement.

4 investors

Forever Labs operates a stem cell banking service that collects, processes, and cryopreserves adult stem cells from individuals for potential use in future regenerative therapies. The company connects patients with a network of board-certified physicians across the United States and coordinates cell storage and therapeutic activation.

4 investors

Fountain Life is a private preventive health membership service that uses AI-guided diagnostics, physician-led interpretation, and restorative therapeutics to detect issues early and create personalized plans focused on healthspan and longevity. It offers members always-on access to an integrated care team and an AI medical expert platform (Zori), delivered through clinics located across the United States.

4 investors

Holoclara develops therapeutics derived from symbiotic intestinal organisms (helminths) that modulate inflammation, metabolism, and tissue regeneration to address chronic disease, immune-related conditions, and aging. The company aims to reintroduce beneficial worm-derived components without live worms.

4 investors

Immunis Biomedical develops multi-active biologics based on stem cell-derived secretomes — cell-free therapeutics containing proteins, lipids and growth factors — aimed at treating age-related and immune-related diseases. Its approach targets multiple biological pathways at once rather than a single protein or mechanism.

4 investors

LifeQ develops a health technology platform focused on longevity, biological age optimization, and performance metrics for individual health monitoring and management.

4 investors

Maxwell Biosciences develops therapeutics aimed at treating infectious diseases. The company works with research and defense institutions on biodefense and antimicrobial-related work.

4 investors