Deep Tech Startups

Relation is an end-to-end biotech company that combines single-cell multi-omics from patient tissue, functional assays, and machine learning to identify druggable targets and develop therapies for serious diseases. Its "Lab-in-the-Loop" platform integrates single-cell analysis, genomics, and machine learning to drive disease understanding from cause to cure.

4 investors

Relectrify develops battery energy storage systems and cell-level management software to reduce the cost of renewable energy. The company serves energy storage operators and renewable energy developers seeking improved efficiency, longevity, safety, and financial returns.

4 investors

Reshape provides an AI-driven operating system that automates microbiology data capture and analysis for research laboratories. The platform structures experimental results and surfaces insights to help lab teams accelerate research and product development.

4 investors

Resonado is a hardware design and engineering lab focused on improving the acoustic performance of audio products. It develops technology for the next generation of audio hardware.

4 investors

Reveal Technology develops defense software solutions for warfighters, first responders, and military personnel. The company builds technology products that support tactical military and law enforcement operations.

4 investors

Ricursive Intelligence is an AI lab developing self-improving systems focused on chip design, aiming to close the feedback loop between AI and hardware development to accelerate progress toward artificial superintelligence.

4 investors

RLWRLD develops robotic hand dexterity solutions using proprietary motion capture data and foundation models for industrial automation tasks. The company serves manufacturing, logistics, and services sectors by enabling robots to perform precision hand tasks that currently require human workers.

4 investors

Roebling provides integrated software for capital project teams to connect process models, cost estimates, and business cases in a single system. The platform enables teams to test assumptions and scenarios without rebuilding spreadsheets, serving engineering and project finance teams in capital-intensive industries.

4 investors

Salient produces AI-powered subseasonal-to-seasonal weather and climate forecasts spanning one day to one year, using deep neural networks trained on ocean, land-surface, and climate data. Its forecasts and analytics serve industries including agriculture, energy, finance, and supply chain, delivered through decision tools, a map interface, and APIs.

4 investors

Satim provides AI-powered detection, classification, and identification of vessels, vehicles, and aircraft from synthetic aperture radar (SAR) data collected by satellites and unmanned aerial vehicles. The platform processes raw SAR sensor data into operator-ready intelligence for defense and intelligence applications.

4 investors

SCINTIL Photonics develops integrated silicon photonics laser sources, including a single-chip DWDM-native multi-wavelength laser (LEAF Light) built on its SHIP heterogeneous integration process, for optical interconnects in AI datacenters. Its products target the scale-up compute networks of AI accelerators that require high-speed, low-latency, power-efficient optical transceivers.

4 investors

Scioto Biosciences is a life sciences company with corporate offices and research facilities in Fishers, Indiana. This page describes its office locations and employee benefits rather than detailing its products.

4 investors

Scout Bio developed biotechnology therapies for pets, including a pipeline of monoclonal antibodies and gene therapy programs targeting chronic diseases in companion animals. The company was acquired by animal health firm Ceva in early 2024, and its work now operates as Ceva's biotechnology campus in Philadelphia.

4 investors

Sention provides battery analytics using ultrasound imaging, data fusion, and AI to give visibility into battery internals for researchers, manufacturers, and operators. Its tools detect anomalies, grade cells, forecast degradation, and track state-of-charge across the battery lifecycle for applications such as EV and BESS.

4 investors

Septerna develops oral small molecule drug candidates targeting G protein-coupled receptors (GPCRs) using its proprietary Native Complex Platform. The company's pipeline focuses on endocrinology, immunology and inflammation, and metabolic diseases for patients with unmet medical needs.

4 investors

Serna builds a platform to unlock the transcriptome as a drug target for drug discovery. The company integrates technology and biology to change drug discovery processes.

4 investors

Sieve creates high-quality multimodal datasets and training environments for frontier AI labs developing generative media, robotics, and agentic systems. The company combines exabyte-scale infrastructure with novel data collection and processing techniques to serve AI research teams and enterprise customers.

4 investors

Silimate builds AI-powered EDA software that accelerates chip design workflows by combining fast computation engines, machine learning models, and user-friendly interfaces. The platform serves SoC and IP companies in hardware design by functioning as a copilot to help chip designers understand design tradeoffs and iterate faster.

4 investors

SimScale provides a cloud-based simulation platform that combines computational fluid dynamics, finite element analysis, thermal, and electromagnetics capabilities with AI-powered tools for engineers. The platform enables engineering teams to rapidly test design options and make decisions without requiring specialized CAE expertise or dedicated hardware.

4 investors

Singular Genomics develops spatial pathology technology to map molecules and cells directly in tissue for disease characterization. The company serves researchers and pathologists in biomedical research and diagnostics.

4 investors

Sinumy develops hands-free authentication technology, described as a first-of-its-kind in Japan and globally. The company builds this deeptech recognition/authentication technology and pursues partnerships and new business ventures around it.

4 investors

Smack builds domain-specific AI models for military decision-making. The company serves defense and military organizations across branches including the Air Force, Navy, Marines, and Special Operations Command.

4 investors

Snowcap Compute develops superconducting computing platforms using Josephson Junctions to replace semiconductor transistors, delivering orders-of-magnitude greater energy efficiency for AI and high-performance computing workloads. The technology operates on proven cryogenic infrastructure and uses standard semiconductor manufacturing processes.

4 investors

Sofant develops satellite communication terminal technology, including RF MEMS beamforming phased array antennas, optimized for size, weight, power consumption and cost. Its terminals support multi-beam, multi-orbit connectivity across LEO, MEO and GEO networks for ground, sea, and airborne applications.

4 investors