Deep Tech Startups

AbCellera develops antibody-based medicines using a technology platform that integrates biology, computation, and engineering, working with pharmaceutical partners on antibody drug programs including bispecifics and antibody drug conjugates. The company operates in the biotech and drug discovery sector, focusing on first-in-class and best-in-class antibody therapeutics for complex targets such as transmembrane proteins.

5 investors

Abogen is a biotechnology company developing mRNA-based therapeutics and vaccines, including an mRNA shingles vaccine and mRNA-encoded T-cell engagers for cancer such as B-cell non-Hodgkin lymphoma. Its work spans preclinical research and clinical-stage programs in RNA technology and lipid nanoparticle formulation.

5 investors

Actithera develops a chemistry platform for targeted cancer treatment that optimizes radiation dose absorption in tumors while reducing exposure to healthy tissue, with flexibility to pair different radionuclides based on tumor characteristics.

5 investors

Active Surfaces develops flexible, thin-film solar panels using organic and perovskite photovoltaic materials and roll-to-roll manufacturing, aimed at deploying solar in locations where conventional rigid panels are unsuitable. The company builds on printed electronics and materials research to make lightweight solar for remote and unconventional surfaces.

5 investors

Addis Energy develops technology that combines oil and gas engineering expertise with advanced research to access energy and resources from subsurface geology.

5 investors

Adept Materials develops advanced materials for building envelopes that improve energy efficiency, durability, and moisture management without sacrificing comfort. The company's technology mimics biological moisture regulation mechanisms to help buildings reduce heating and cooling energy consumption.

5 investors

Advemto maps complex cell function to genetic sequences at scale without requiring new laboratory instruments. The platform targets therapeutic development and TechBio companies seeking to accelerate preclinical validation of next-generation therapeutics.

5 investors

Aera Therapeutics develops genetic medicines using next-generation delivery technologies and precision payloads optimized for specific diseases. The company focuses on advancing transformative treatments in areas including oncology, rare genetic diseases, and cell therapies.

5 investors

Aerospacelab designs, builds, and operates satellite infrastructure, including platforms, payloads, subsystems, and operations for Earth observation, intelligence, and connectivity missions ranging from single in-orbit demonstrations to full constellations. It serves government and commercial customers with an ITAR-free, European supply chain and is building a Megafactory in Europe capable of producing 500 satellites per year.

5 investors

Agile Devices develops microcatheters using patented coaxial deflection technology for interventional vascular procedures. The company's Angler® device is designed to improve vessel navigation and reduce procedure time and cost in peripheral and coronary applications.

5 investors

AgileRL develops an open-source reinforcement learning framework for training and tuning AI agents faster than existing RL libraries, along with Arena, an enterprise platform that converts raw data into production-ready agents. It works with companies in industries such as finance, defence, and technology.

5 investors

AheadComputing develops high-performance 64-bit RISC-V application processor cores designed to maximize per-core CPU performance for AI, cloud, client, mobile, and edge workloads. Founded by former Intel CPU architects, the company builds general-purpose compute IP aimed at eliminating CPU bottlenecks in latency-sensitive and agentic AI applications.

5 investors

ai-coustics provides an audio reliability layer with speech technology such as Voice Focus, which removes background noise and other voices to improve transcription accuracy and keep voice agents responsive in noisy environments. It offers an SDK with real-time, low-latency inference for developers building voice applications across STT, TTS, and LLM stacks.

5 investors

Alchemab operates a platform that identifies novel drug targets and therapeutics by analyzing patient antibody repertoires using deep B cell sequencing and computational analysis of samples from disease-resilient individuals. The company develops protective antibody therapeutics for hard-to-treat diseases, with an initial focus on neurodegenerative conditions and oncology.

5 investors

Alchemy is a nanotechnology company developing protective coatings and films, including the ExoShield windshield protection line for vehicle owners and an infrared camouflage technology developed with the Canadian Armed Forces. It serves the automotive aftermarket and defense sectors.

5 investors

Algen Biotechnologies discovers and develops small molecule therapeutics for cancer and inflammatory diseases using CRISPR, RNAi, and machine learning to decode functional gene networks and predict drug responses.

5 investors

Algorized develops edge-AI software and algorithms for wireless sensors that detect human presence, track positioning, and monitor vital signs, including through obstacles. Its perception technology is applied to people safety across robotics, industrial, automotive, human-machine interaction, and infrastructure use cases.

5 investors

Alixia develops therapeutics targeting tumor ecosystems to address cancer drug resistance and age-related diseases. The company integrates biology, biophysics, and computational chemistry to design compounds that disrupt metabolic and inflammatory triggers in multiple cell types within the tumor microenvironment.

5 investors

Alloy provides drug discovery services and platform technologies across genetic medicines, TCR mimics, and cell therapies, supporting pharmaceutical partners in developing novel treatments.

5 investors

Allozymes develops custom enzymes using high-throughput experimentation combined with AI-guided design for enzyme engineering and biocatalysis. It applies these engineered enzymes to industrial and scientific applications.

5 investors

Alsym Energy develops non-flammable, high-performance sodium-ion batteries for energy storage applications. The company serves the energy storage market with an American-made alternative to lithium-ion technology.

5 investors

Althea builds a blockchain-based settlement layer (Althea L1) for open-access telecom and infrastructure networks, enabling autonomous machines and community-owned internet service providers to operate. It works with ISPs, nonprofits, and cooperatives to deliver high-speed internet to rural and underserved communities in the US and abroad.

5 investors

Altos Labs develops computational and scientific approaches to reverse disease through breakthrough medicines, operating research institutes focused on cell health, computation, and drug discovery.

5 investors

Alva Industries develops electric motors and drive systems using a patented FiberPrinting production technology for ironless, slotless stator windings, offering compact torque motors such as SlimTorq and GearTorq. The company targets electrification across multiple industries with a focus on high torque-density and lightweight motor designs.

5 investors