Deep Tech Startups

SkyDrive is a Japanese company that develops, manufactures, sells, and operates flying cars, specifically electric vertical takeoff and landing (eVTOL) aircraft. It works in the advanced air mobility and aerospace industry.

6 investors

Smallest AI develops small, efficient multi-modal voice AI models, including text-to-speech, speech-to-text, and a sub-3B language model, along with an agentic platform for building and deploying voice agents. It offers production-grade audio models and developer tools aimed at enterprises building real-time voice applications.

6 investors

Somewear builds a software-defined edge networking system that routes mission data across narrowband, mesh, and satellite links to keep teams and unmanned platforms connected in contested or degraded conditions. Its hardware and software products, including an ATAK plugin, serve defense, special forces, and emergency response teams needing resilient tactical communications and command and control.

6 investors

SonoThera is developing a nonviral, non-invasive gene delivery technology that uses ultrasound and microbubbles (ultrasound-mediated delivery) to deliver genetic payloads to targeted sites in a redosable way. The company works on genetic medicine, aiming to address limitations in delivery, safety, durability, and cost.

6 investors

SKY-I is a platform that aggregates fragmented space environmental data into a single system, offering 3D mapping of orbital conditions, satellite positions, and environmental hazards from VLEO to cislunar space. It provides satellite operators and mission engineers with environmental intelligence, anomaly tracking, and API integration to speed up mission planning and reduce mission risk.

6 investors

Space Kinetic develops technology to enable frequent, low-cost maneuvering and operations for spacecraft and space systems. The company aims to make space exploration and commercial space activities more affordable and accessible by addressing fundamental constraints in orbital mechanics.

6 investors

Spectera Aerospace develops propulsion and flight systems for the aerospace industry. Based near Boston, the company has been innovating in aerospace technology for 13 years.

6 investors

Stämm is a biomanufacturing company founded in 2016 that builds the Bioprocessor, a continuous, bubble-free bioreactor using single-use 3D-printed cartridges for producing monoclonal antibodies, biosimilars, and cell and gene therapies. It serves biologics producers seeking lower costs and scalable, automated manufacturing.

6 investors

Steady Energy develops the LDR-50, a low-temperature heat reactor based on technology from the Technical Research Centre of Finland. The company commercializes this reactor technology for industrial and environmental applications.

6 investors

Sunthetics develops machine learning algorithms and software for chemical engineering applications. The company serves industrial and R&D teams in the chemical and materials sectors.

6 investors

Supercritical develops a high-pressure, efficient electrolyser technology for producing green hydrogen, enabling industrial transition away from fossil fuels. The company serves industries requiring hydrogen for chemical production, refining, and energy applications.

6 investors

Synteny develops an AI platform that models the rules of molecular recognition to design modular protein therapeutics, pairing generative biology models with high-throughput experimental validation. The company is building a pipeline of T cell receptor T cell engager (TCR TCE) therapeutics targeting intracellular proteins for solid tumour oncology and cell-specific depletion in immunology.

6 investors

Syntis Bio develops oral therapies that use the biology of the small intestine to treat conditions ranging from rare genetic disorders to common diseases. The company is advancing a pipeline of drug candidates across multiple therapeutic areas, beginning with obesity.

6 investors

Tacit Therapeutics develops RNA-based gene therapy approaches by redirecting cellular splicing processes to repair mutated genes. The company serves patients with genetic diseases and is based in San Francisco.

6 investors

Ten63 develops drug-discovery technology that combines generative chemistry with quantum-accurate molecular simulation, including BEYOND (a large quantum chemistry model) and Sentinel (a virtual CSO for target selection), to design therapeutics against previously undruggable targets. It runs an internal pipeline of first-in-class and best-in-class programs across oncology and other serious diseases.

6 investors

Teramount develops the Universal Photonic Coupler, a technology that connects optical fibers to silicon photonics for co-packaged optics, transceivers, and sensors used in AI/ML processors, switches, and other advanced computing. It targets data centers, telecom, and 5G/6G network applications, enabling high-volume manufacturing of high-bandwidth, low-power products.

6 investors

Third Dimension builds spatial reconstruction and generation technology that creates high-fidelity digital worlds for autonomous systems to train on and operate reliably in the real world. The company addresses the simulation-to-reality gap that currently constrains autonomous robotics development.

6 investors

TRIANA Biomedicines is a venture-backed biopharmaceutical company developing small-molecule "molecular glue" therapeutics that induce protein:protein interactions to degrade or alter disease-causing target proteins, with an initial focus on targeted protein degradation for cancer. The company applies a target-first molecular glue discovery platform to pursue disease targets previously considered undruggable.

6 investors

Trogenix develops precision gene therapies for cancer using its Odysseus platform and Synthetic Super-Enhancer (SSE) technology, engineered DNA elements activated only in diseased cell states to selectively target and kill tumour cells while activating the immune system. Its lead program, TGX-007, is a gene therapy for glioblastoma in a Phase I/II clinical trial, with potential applications in solid tumours and regenerative medicine.

6 investors

Unsiloed builds AI models that read and analyze document pages using attention-guided heatmaps to identify and extract structured data from tables, figures, and text regions. The product serves organizations that need to process complex multi-page documents and extract information while preserving hierarchical relationships.

6 investors

Thesis develops reusable, steerable microballoons for routine access to the stratosphere (40,000–130,000 feet), enabling persistent surveillance, communications relay, and atmospheric research for defense, intelligence, commercial, and scientific applications.

6 investors

Vaulted Deep repurposes oil and gas infrastructure and expertise to enable carbon removal and waste management at scale. The company injects carbon-rich waste streams underground to address carbon pollution and overburdened waste systems.

6 investors

Vena Medical develops a miniature camera designed for use inside blood vessels, aimed at physicians performing neurovascular procedures. The company has published pre-clinical results and is pursuing regulatory clearance to commercialize the technology.

6 investors

Veritas In Silico develops AI-driven drug discovery platforms targeting RNA and nucleic acid-based therapeutics, partnering with pharmaceutical companies for small molecule and mRNA drug creation.

6 investors