Deep Tech Startups

OneSky is a UAS Traffic Management (UTM) company building airspace assessment, operations, and traffic management software for the aviation industry, serving drone operators, drone manufacturers, and airspace authorities. Spun out of Analytical Graphics, Inc., it has deployed and validated its technology with organizations such as the FAA, NASA, the Civil Aviation Authority of Singapore, and Airservices Australia.</parameter> <parameter name="founders">[{"full_name": "Robert Hammett", "title": "CEO"}]

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OpenBench runs AI-enabled structure-based virtual screening to identify small molecule hit series for biotech drug discovery programs, screening large compound libraries and charging only for hits that meet a client-defined profile. It works with clients' own assays and CROs, offering a success-driven model where collaborators purchase resulting IP outright.

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Ophirex is a biotech company developing varespladib, an investigational oral capsule intended to treat snakebite envenomation by inactivating a key venom toxin found in most snake species. The drug is designed as a portable, field-administered rescue treatment to bridge the gap before hospital antivenom.

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Optex Systems manufactures optical sighting systems and assemblies for U.S. Department of Defense applications, with products installed on military vehicles including the Abrams, Bradley, and Stryker platforms. The company also produces periscopes, rifle sights, surveillance sights, and night vision optical assemblies for military and defense contractors.

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Optomec builds additive manufacturing systems, including 3D metal printers and 3D printed electronics equipment, for industrial production, repair, and prototyping. Its customers include manufacturers, academic institutions, and government organizations.

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Oragenics develops treatments for concussion and traumatic brain injury, focusing on clinical development of therapeutic candidates. The company combines neuroscience expertise with healthcare operational leadership to advance solutions for brain injury treatment.

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OSS manufactures testing technology for measuring contaminants in ammonia and related chemical products, including oil content, water content, and formaldehyde. The company provides extraction and analysis solutions for manufacturers of ammonia, DEF, urea, and related compounds.

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Otomagnetics develops a non-invasive magnetic injection system to deliver drugs and therapeutic payloads to the inner and middle ear, the eye, and the skin, aimed at treating conditions such as inner ear diseases. The technology has demonstrated drug delivery to the inner and middle ear in animal models without puncturing the eardrum.

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Outside Analytics builds operational software systems for remote sensing, real-time processing, and analytics in the aerospace industry, turning raw data into decision information. The company serves aerospace and mission-focused customers and is headquartered in Colorado.

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OyaGen is a preclinical drug discovery and development company that identifies and optimizes lead compounds as investigational new drugs for infectious diseases and cancer, then licenses or partners them with industry leaders for clinical development. It also offers fee-for-service assay development and high throughput screening to academic and industry partners.

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Pacific DT develops a patented prototype system emerging from university research with support from major health foundations and government agencies. The company is transitioning from research stage toward commercial clinical applications.

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Pandora Bio develops ML-based personalized diagnostics for mental health applications. The company works in the healthtech space, combining machine learning with clinical expertise to support diagnostic and therapeutic outcomes.

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ParcoData develops nuclear-powered, behind-the-meter data center campuses that generate their own clean electricity and use dry, sealed-loop cooling to serve hyperscaler and enterprise AI, inference, and HPC tenants. The campuses combine five revenue lines — powered shell leasing, on-site power contracts, immersion cooling technology, medical radioisotope production, and waste-heat carbon capture — anchored in Nevada with a planned six-metro U.S. footprint.</parameter> <parameter name="founders">[]

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ParkerVision develops radio-frequency and wireless communications technology used in mobile and consumer devices such as phones and earbuds, and is building technology aimed at reducing the cost of delivering 5G and 6G networks. The U.S.-based company focuses on semiconductor and RF innovation for next-generation wireless infrastructure.

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PDX Pharmaceuticals develops mesoporous silica nanoparticle platforms to co-deliver drugs, siRNA, and immunotherapy for treating multiple cancers and skin diseases. The company works in collaboration with OHSU on targeted and combination immunotherapeutics.

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Pebble Labs develops Directed Biotics technology, using microbes and RNA interference-based molecules to activate defense mechanisms in host crops. The company applies computational biology and bioinformatics to agricultural applications such as crop protection.

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Penrove provides tools and frameworks designed to simplify essential, safety-critical tasks for organizations in complex, high-stakes environments. The company aims to help teams gain clarity and speed in their work to focus on innovation.

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Permissionless Labs is an AI lab that builds serving, storage, and training infrastructure with first-class support for open-weight models and open standards, making its systems available to anyone who wants to build on them. It emphasizes data portability and no vendor lock-in, serving developers and companies building AI applications from prototype to production.

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PhenoVista provides contract research services focused on phenotypic and high-content imaging studies, using quantitative fluorescence microscopy and cell-based disease models to support R&D and drug discovery decisions. It serves life science and biotech researchers.

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Phio Pharmaceuticals is a clinical-stage biopharmaceutical company developing INTASYL, a proprietary self-delivering siRNA gene silencing technology that makes immune cells more effective at killing cancer cells. Its immuno-oncology pipeline targets cutaneous squamous cell carcinoma (cSCC) and melanoma.

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PiroGon is developing a closed-loop medical platform, based on technology from Yale University, that detects the backflow and spillover of stomach acid and dynamically restores airway protection to prevent aspiration pneumonia. It targets patients at risk of aspiration across neurologic, surgical, and critical-care settings.

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Plasmology4 develops Plaz4, a non-thermal (cold) plasma technology for medical applications, with its first product, the Plaz4 1000 system, aimed at treating antibiotic-resistant infections and chronic non-healing wounds. It is a pre-revenue medical device company in the emerging field of plasma medicine, and its lead product has received FDA Breakthrough Device designation but is not yet approved for sale.

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Pluristyx develops induced pluripotent stem cell (iPSC) technologies, including non-modified and genetically engineered cell lines, proprietary gene edits, and reprogramming platforms, along with related services. It provides these products and end-to-end development support to companies building cell and stem cell therapies.

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Polybiomics develops a live cell analysis platform that measures multiple phenotypes and functions of cells simultaneously and continuously without disrupting them or their 3D environments. The system combines a bioinstrument, consumable, and the PolyData analytics engine with AI to interpret multimodal datasets for research, pharmaceutical, biomanufacturing, and clinical workflows.

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