Deep Tech Startups

Myris Therapeutics applies polymer chemistry to develop next-generation medicines, with a flagship platform of ultra-high DAR antibody drug conjugates (ADCs). Its technology uses ATRP "growing from" methods to build polymer bottlebrushes that carry payloads, aimed at targeted cancer therapies across oncogenic pathways.

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Myrtelle develops gene therapies for neurological diseases, particularly white matter disorders of the central nervous system. The company is conducting clinical trials for Canavan disease using novel AAV vector technology to target oligodendrocytes.

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NANO Nuclear Energy is a vertically integrated company developing advanced portable microreactor technology, including the KRONOS MMR, spanning reactor design, safety analysis, fuel cycle facilities, and licensing. Publicly listed on NASDAQ, it serves the advanced nuclear energy sector.

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NanoGuard Technologies is a deep-technology company developing High Voltage Atmospheric Cold Plasma treatment technology and its applications. It works across scientific, technical, and commercial disciplines to evaluate application needs based on data.

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Nanoscale Powders manufactures high-purity metal powders including titanium, refractory metals, and silicon alloys using proprietary processes for aerospace, energy, and battery applications. The company serves industrial customers in advanced materials sectors.

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NantOptiFab produces thin film lithium niobate (TFLN) and silicon wafers in-house and fabricates photonic chips and devices for telecom, AI interconnects, defense, and quantum applications. The company operates its own electro-optics fabrication facilities in California with a fully US-based supply chain.

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Navrogen is a biopharmaceutical company developing therapeutic agents that counter tumor-produced Humoral Immuno-Oncology (HIO) factors linked to suppressed humoral immunity and poor response to immune-mediated anti-cancer therapies. It uses proprietary screening, antibody engineering technologies, and diagnostic assays to identify patients whose tumors produce HIO factors, targeting cancer and immune-related disorders.

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Near Space Corporation provides stratospheric balloon and high-altitude platform products and services for aerospace testing and flight operations. The company, based in Tillamook, Oregon, was acquired by Aerostar International LLC in March 2024.

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Nebula Space Enterprise, Inc. focuses on space exploration and access to deep-space resources, operating through five entities spanning blockchain, cybersecurity, computing, an incubator, and media.

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Neuroelectrics develops the Starstim platform, combining EEG monitoring headpieces, cloud-based delivery, and personalized protocols to deliver non-invasive Transcranial Electrical Stimulation (tES) neuromodulation therapy for brain disorders such as depression and epilepsy. It serves patients whose conditions are not controlled by drugs or surgery, as well as neuroscience researchers who use its tools for brain research.

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NewSight Reality develops optical and augmented reality technology, drawing on ophthalmic and photonic engineering expertise. The company's work spans optical instrumentation and display devices.

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Next Wave Partners is a venture studio and fund investing exclusively in companies at the intersection of autonomy, physical AI, and infrastructure, including agentic AI, robotics, edge computing, and intelligent infrastructure. The firm provides patient capital, embedded operational support from experienced executives, and founder-aligned revenue-based capital structures designed for deep tech companies.

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ni2o is a US-based company developing AI and brain-computer interface (BCI) technology to detect and treat neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. Its products span software for ultra-early detection, a wearable EEG-like headcap for monitoring and non-invasive stimulation, and a minimally invasive brain micro-implant.

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Personal site of Nicole Junkermann, a German-born entrepreneur and investor based in London who invests through NJF Holdings and its venture arm NJF Capital across fintech, AI, deep technology and life sciences, plus a sports investment platform. As an investor rather than an operating company, her portfolio spans early-stage technology firms and sports leagues and media.

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NioCorp is a mining and mineral extraction company developing the Elk Creek Project to produce niobium, scandium, magnetic rare earths, and titanium.

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Nona Technologies makes RECOVER, a modular retrofit system that uses an MIT-patented Ion Concentration Polarization process to clean and recycle cooling-tower blowdown water, reducing water waste and cooling OpEx. It targets data centers and industrial facilities facing water constraints on their cooling systems.

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Norsk Titanium manufactures aerospace-grade titanium preforms using additive manufacturing (RPD® technology) for structural applications in aerospace and defense. The company operates three facilities across the U.S. and Norway with ITAR-registered production capability and serves aerospace, defense, and industrial customers requiring repeatably qualified components.

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NovaSolix develops a solar energy device that uses nanoscale antenna arrays to convert the full solar spectrum (UV to IR) directly into electrical power, aiming for higher power density and efficiency than traditional photovoltaics. It targets manufacturers and integrators seeking high-output solar for applications needing maximum output in minimal space.

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Nuvvon develops next-generation battery technologies, focusing on polymer and battery materials research and development. The company works on solid-state battery materials and energy storage technologies.

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NV Therapeutics develops non-viral gene therapies designed to be safe, effective, and scalable. The company targets a new generation of genetic treatments for disease.

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Nxbeam is a technology company operating in the semiconductor and communications space. The about page profiles its leadership rather than detailing a specific product.

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Objective Biotechnology develops neurotechnology tools for cortex-wide optical access and neural recordings in unrestrained rodent models, along with automated microinjection systems for large-scale genetic manipulation and embryo microinjection. Its products serve researchers working with biological systems.

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Oboro Labs develops catalyst technology to mass-produce cyclic polymers, materials aimed at applications such as low-friction coatings, lightweight electronic materials, and drug delivery systems. The company, spun out of research at the University of Florida, works to commercialize these polymers for use across manufacturing and consumer product industries.

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Ommo develops spatial tracking technology that provides 3D pose and position data in complex real-world environments, including safety-critical medical settings. Its proprioceptive tracking layer is designed to complement and correct perception systems by delivering ground-truth pose data through contact and interaction.

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