How many investments has Region Cuatro made?

Region Cuatro has 13 tracked investments.

What stage does Region Cuatro invest at?

Region Cuatro invests at the Pre-Seed, Seed stages.

What sectors does Region Cuatro focus on?

Region Cuatro focuses on AI & Machine Learning, Fintech, Impact & Social Good, SaaS, Sector Agnostic.

Where is Region Cuatro located?

Region Cuatro is headquartered in California, US.

Who does Region Cuatro co-invest with?

Region Cuatro most often shares deals with Y Combinator, FundersClub, Soma Capital, among 49 tracked co-investors.

Region Cuatro

Venture capital

California · Pre-Seed–Seed · 2 people tracked

Also known as Region 4

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Investment thesis

Region Cuatro backs early-stage founders who demonstrate speed, grit, and product obsession, particularly those building AI-native companies with lean teams. The firm leverages its operator network of engineers, product builders, and founders to embed with companies from day one. The investment thesis emphasizes identifying emerging talent, especially from the Latin American startup ecosystem, that can scale globally using technology to remove friction and operate efficiently.

Invests inAI & Machine Learning Fintech Impact & Social Good SaaSSector AgnosticAsia-Pacific Europe Global Latin America North America United States

Source: firm website, verified Sep 5, 2026.

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Stage

Pre-Seed–Seed

California, US

Instruments

Equity

Founded

2021

Tracked investments

Unicorns

Team · 2 people

from public directories

Christian Van Der Henst· San Francisco, California, United Statesin

Christian Van Der Henst is Managing Partner at Region Cuatro and an angel investor in Latin American and Silicon Valley startups, including Rappi, Toku, OnTop, Nuvocargo, Pachama, Treble, Trii, April, and KiloCode. He co-founded Platzi, an online technology school in Spanish with over 6 million students, and began his career in 1997 with Maestros del Web, an early webmaster community in Latin America. He is a Y Combinator W15 alum.

Federico Soria

What they invest in

from 9 of 13 portfolio companies

SaaS ×4Enterprise Software ×3Fintech ×3Advanced Manufacturing ×2AI & Machine Learning ×2E-commerce ×2Hardware ×2Robotics ×2

HQs:United States×5Mexico×3Colombia×1Panama×1

Who they back

founder profiles across 9 portfolio companies

11%

solo founders

1 of 9 mapped founding teams

42%

repeat founders

of 19 founders with career history

Founding team size:solo founder×12 founders×33 founders×24+ founders×3

Where their founders studiedfrom 19 founders with education data

Pontificia Universidad Católica de Chile ×3Georgetown ×2Tecnológico de Monterrey ×2Universidad de Guadalajara ×2Universidad de Los Andes ×2

What their founders studiedfrom 18 founders with field-of-study data

Business & Management ×6Economics ×5Engineering ×5Computer Science ×2

Where their founders worked beforefrom 19 founders with career history

Sia Partners ×2

Accelerator rootsportfolio companies that came through a program

Y Combinator ×7

2 hold an MBA (of 21 with degree data)

Investments · 13 tracked

founders shown can be your intro path

Exit FinTech, Uruguaybrinta.com

Michel Golffed(Founder)Rodrigo Sanchez Prandi(Founder)

Co-investors17Sigma Gilgamesh Ventures Kaszek Ventures

Guardian RFguardianrf.com in 𝕏

Guardian RF builds sensing technology to provide visibility and monitoring of low-altitude airspace.

Advanced ManufacturingDeep TechDefense TechHardwareIoTRoboticsWashington, US

Lucas Raskin(CEO)in John Andrzejewski(COO)in Eli Kerstein(CTO)in

Co-investorsY Combinator Andreessen Horowitz Romulus Capital Space Capital

itemitem.app in 𝕏Seed

Item is an AI-native CRM designed to replace traditional customer relationship management systems, built for high-growth companies and teams in go-to-market operations.

AI & Machine LearningEnterprise SoftwareSaaSSales TechSan Francisco, US

Andres Santanilla(CEO)in Akshay Guthal(CTO)in

Co-investorsPioneer True Ventures Y Combinator 468 Capital Matrix Spot VC +1 more

L1 Advisorsl1.co in

Point Roberts, US

Miguel Kudry(Executive Officer, Director)in

Co-investorsVanEck

Lead Salesleadsales.io in 𝕏

Leadsales is a CRM platform that centralizes customer conversations from WhatsApp, Facebook, and Instagram in a single interface, enabling sales teams to manage leads, automate follow-ups, and organize sales processes.

Marketing TechSaaSSales TechSantiago de Querétaro, MX

Roby Peñacastro(Founder)in David Villa(Founder)in

Co-investorsAltered Ventures Breakaway Partners OÜ Gaingels Latitud Ventures StartX Ulu Ventures +1 more

PayCaddypaycaddy.com in 𝕏Seed

PayCaddy provides a platform that allows Latin American companies to launch financial products including digital wallets, payment automation, and card issuance through API integration rather than building from scratch or using traditional banks.

FintechPanama City, PA

Juan Diego Galvez(Founder)in Federico Benavides(Founder)in

Co-investorsAAF Management Ltd.Cathexis Ventures Flucas Ventures Kube VC Rebel Fund Soma Capital +4 more

Rappirappi.com in 𝕏

Rappi is a delivery and logistics platform that connects merchants and delivery partners with millions of users across multiple countries in Latin America, offering immediate delivery services and payment opportunities for couriers.

ConsumerE-commerceFintechFoodTechLogistics & Supply ChainMarketplacesBogotá, CO

Simon Borrero(CEO)in Sebastian Mejia(Founder)inFelipe Villamarin(Founder)in Simón Borrero(Founder)inFelipe Villamarina(Founder)Felipe Villamarín(Founder)

Co-investorsAndreessen Horowitz ARTFO Holdings LLC Base Partners DVC FJ Labs Floodgate +45 more

Red Barn Roboticsredbarnrobotics.com in 𝕏

Red Barn Robotics develops autonomous weeding robots for farms to eliminate intra-row weeds without human intervention, reducing labor costs and protecting soil health.

Advanced ManufacturingAgTechHardwareRoboticsSeattle, US

Adam Iseman(CEO)in Ilya Kelner(CTO)in Alex Neff(COO)in

Co-investorsPioneer Vermilion Cliffs Ventures Y Combinator Agrolimen Ventures Aliaksandr Hudzilin Batch Ventures +5 more

Riveterriveterhq.com in 𝕏Seed

Riveter is a web data extraction and automation platform that searches, navigates, and retrieves specific information from the internet for teams across e-commerce, marketing, real estate, and other data-dependent industries.

AI & Machine LearningData & InfrastructureDeveloper ToolsE-commerceEnterprise SoftwareSaaSSan Francisco, US

Abigail Grills(CEO)in Amy Nelson(Executive Officer, Director)inErica Clark(CTO)

BoardHope Cochran(Director)

Co-investorsTranspose Platform Management Y Combinator Alpha Edison Founders' Co-op Madrona Venture Group NAINARTHA UNLIMITED +2 more

Terapifyterapify.com in 𝕏Seed

Terapify is an online mental health platform that connects users with licensed psychologists for individual and couple therapy sessions, along with supplementary wellness content such as yoga classes and guided meditations.

HealthtechMental HealthWellness & FitnessMexico City, MX

Juan Daniel Velez Santiago(Founder)inEduardo Velez Santiago(Founder)inDaniel VelezinEduardo Velezin

Co-investors500 Global Y Combinator 1984 Ventures Management, Llc Bamboo Capital Partners Carabela Cibersons +6 more

Tokutrytoku.com in 𝕏Seed

Toku provides software for Latin American businesses to manage accounts receivable operations, including payment processing, retry logic for failed transactions, and customer notifications, allowing companies to improve cash collection efficiency.

Enterprise SoftwareFintechSaaSMexico City, MX

Francisca Noguera(Founder)in Cristina Etcheberry(Founder)in Enzo Tamburini(Founder)inDominika Stobiecka(Founder)Enzo Tamburini Heinz(Founder)Francisca Noguera Astaburuaga(Founder)

Co-investorsF-Prime Capital FundersClub Gradient Ventures Honey Island Capital Oak HC/FT Wollef Ventures +14 more

Other

Tracked investments with no reachable website or further public details — typically companies that wound down, renamed, or were absorbed.

ApprecioMercury

Portfolio news

latest coverage across their companies

Riveter - Turn any prompt into a fully enriched dataset

Riveter · ycombinator.com · Apr 14, 2026

item: The AI-Native CRM that works for you

item · ycombinator.com · Nov 3, 2025

Toku Raises $48M in Series A Funding

Toku · finsmes.com · Apr 17, 2025

Frequently asked questions

How many investments has Region Cuatro made?: Region Cuatro has 13 tracked investments.
What stage does Region Cuatro invest at?: Region Cuatro invests at the Pre-Seed, Seed stages.
What sectors does Region Cuatro focus on?: Region Cuatro focuses on AI & Machine Learning, Fintech, Impact & Social Good, SaaS, Sector Agnostic.
Where is Region Cuatro located?: Region Cuatro is headquartered in California, US.
Who does Region Cuatro co-invest with?: Region Cuatro most often shares deals with Y Combinator, FundersClub, Soma Capital, among 49 tracked co-investors.

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