Region Cuatro
Venture capitalCalifornia · Pre-Seed–Seed
Investment thesis
Region Cuatro backs early-stage founders who demonstrate speed, grit, and product obsession, particularly those building AI-native companies with lean teams. The firm leverages its operator network of engineers, product builders, and founders to embed with companies from day one. The investment thesis emphasizes identifying emerging talent, especially from the Latin American startup ecosystem, that can scale globally using technology to remove friction and operate efficiently.
Source: firm website, verified Aug 3, 2026.
What they invest in
from 8 of 12 portfolio companiesFintech ×3SaaS ×3Advanced Manufacturing ×2E-commerce ×2Enterprise Software ×2Hardware ×2Robotics ×2AgTech ×1
HQs:United States×4Mexico×3Colombia×1Panama×1
Who they back
founder profiles across 9 portfolio companiesFounding team size:solo founder×22 founders×33 founders×4
Where their founders studiedfrom 15 founders with education data
Pontificia Universidad Católica de Chile ×3Georgetown University ×2Platanus ×2Universidad de Guadalajara ×2Universidad de Los Andes ×2
Accelerator rootsportfolio companies that came through a program
Investments · 12 tracked
founders shown can be your intro pathCo-investorsStartupsLatitud Ventures
Co-investors17SigmaGilgamesh Ventures
Guardian RF builds sensing technology to provide visibility and monitoring of low-altitude airspace.
Advanced ManufacturingDeep TechDefense TechHardwareIoTRoboticsWashington, US
Lucas Raskin(Founder)inJohn Andrzejewski(Founder)inEli Kerstein(Founder)in
Co-investorsY CombinatorSpace Capital
Leadsales is a CRM platform that centralizes customer conversations from WhatsApp, Facebook, and Instagram in a single interface, enabling sales teams to manage leads, automate follow-ups, and organize sales processes.
Marketing TechSaaSSales TechSantiago de Querétaro, MX
Roby Peñacastro(Founder)inDavid Villa(Founder)in
Co-investorsAltered VenturesLatitud VenturesUlu Ventures
Breakout company in Region Cuatro's angel investing track record
PayCaddy provides a platform that allows Latin American companies to launch financial products including digital wallets, payment automation, and card issuance through API integration rather than building from scratch or using traditional banks.
FintechPanama City, PA
Juan Diego Galvez(Founder)inFederico Benavides(Founder)in
Co-investorsAAF Management Ltd.Cathexis VenturesFlucas VenturesY Combinator
Rappi is a delivery and logistics platform that connects merchants and delivery partners with millions of users across multiple countries in Latin America, offering immediate delivery services and payment opportunities for couriers.
ConsumerE-commerceFintechFoodTechLogistics & Supply ChainMarketplacesBogotá, CO
Simon Borrero(Founder/CEO)inSebastian Mejia(Founder)inFelipe Villamarin(Founder)inLars Niklas Ostberg(Director)Jeff Housenbold(Director)Michael Abramson(Director)
Co-investorsAndreessen HorowitzBase PartnersDVCFJ LabsFloodgateFundersClub+15 more
Red Barn Robotics develops autonomous weeding robots for farms to eliminate intra-row weeds without human intervention, reducing labor costs and protecting soil health.
Advanced ManufacturingAgTechHardwareRoboticsSeattle, US
Adam Iseman(Founder)inIlya Kelner(Founder)inAlex Neff(Founder)in
Co-investorsVermilion Cliffs VenturesY Combinator
Riveter is a web data extraction and automation platform that searches, navigates, and retrieves specific information from the internet for teams across e-commerce, marketing, real estate, and other data-dependent industries.
AI & Machine LearningData & InfrastructureDeveloper ToolsE-commerceEnterprise SoftwareSaaSSan Francisco, US
Abigail Grills(CEO & Co-founder)inAmy Nelson(Executive Officer, Director)
BoardHope Cochran(Director)
Co-investorsTranspose Platform ManagementY CombinatorAlpha Edison
Terapify is an online mental health platform that connects users with licensed psychologists for individual and couple therapy sessions, along with supplementary wellness content such as yoga classes and guided meditations.
HealthtechMental HealthWellness & FitnessMexico City, MX
Juan Daniel Velez Santiago(Founder)inEduardo Velez Santiago(Founder)inDaniel VelezEduardo Velez
Co-investors500 GlobalY CombinatorGoodwater Capital
Toku provides software for Latin American businesses to manage accounts receivable operations, including payment processing, retry logic for failed transactions, and customer notifications, allowing companies to improve cash collection efficiency.
Enterprise SoftwareFintechSaaSMexico City, MX
Francisca Noguera(Founder)inCristina Etcheberry(Founder)inEnzo Tamburini(Founder)in
Co-investorsF-Prime CapitalGradient VenturesHoney Island CapitalOak HC/FTWollef VenturesY Combinator+6 more
Portfolio news
latest coverage across their companiesRappi · latamlist.com · Jul 14, 2026
Riveter · ycombinator.com · Apr 14, 2026
Guardian RF · tipranks.com · Mar 10, 2026
Red Barn Robotics · agfundernews.com · Oct 23, 2025
PayCaddy · thebusinessyear.com · Aug 4, 2025
Toku · entnerd.com · Apr 19, 2025
Frequently asked questions
- How many investments has Region Cuatro made?
- Region Cuatro has 12 tracked investments.
- What stage does Region Cuatro invest at?
- Region Cuatro invests at the Pre-Seed, Seed stages.
- What sectors does Region Cuatro focus on?
- Region Cuatro focuses on AI & Machine Learning, Impact & Social Good, Sector Agnostic.
- Where is Region Cuatro located?
- Region Cuatro is headquartered in California, US.
- Who does Region Cuatro co-invest with?
- Region Cuatro most often shares deals with Y Combinator, Andreessen Horowitz, FJ Labs, among 37 tracked co-investors.
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