Region Cuatro
California · Pre-Seed–Seed
Investment thesis
Region Cuatro backs early-stage founders who demonstrate speed, grit, and product obsession, particularly those building AI-native companies with lean teams. The firm leverages its operator network of engineers, product builders, and founders to embed with companies from day one. The investment thesis emphasizes identifying emerging talent, especially from the Latin American startup ecosystem, that can scale globally using technology to remove friction and operate efficiently.
Source: firm website, verified Jul 20, 2026.
What they invest in
from 7 of 14 portfolio companiesSaaS ×3Advanced Manufacturing ×2Enterprise Software ×2Fintech ×2Hardware ×2Robotics ×2AgTech ×1AI & Machine Learning ×1
HQs:Mexico×3United States×3Panama×1
Investments · 14 tracked
founders shown can be your intro pathGuardian RF builds sensing technology to provide visibility and monitoring of low-altitude airspace. The company serves operators and stakeholders requiring airspace awareness and management capabilities.
Advanced ManufacturingDeep TechDefense TechHardwareIoTRoboticsWashington, US
Lucas Raskin(Founder)inJohn Andrzejewski(Founder)inEli Kerstein(Founder)in
Leadsales is a CRM platform that centralizes customer conversations from WhatsApp, Facebook, and Instagram in a single interface, enabling sales teams to manage leads, automate follow-ups, and organize sales processes.
Marketing TechSaaSSales Tech
Roby Peñacastro
Breakout company in Region Cuatro's angel investing track record
Portfolio company currently supported by Region Cuatro
Breakout unicorn in Region Cuatro's angel investing track record
Red Barn Robotics develops autonomous weeding robots for farms to eliminate intra-row weeds without human intervention, reducing labor costs and protecting soil health. The company offers a service model where it maps fields, schedules custom weeding plans, and deploys robots throughout the growing season.
Advanced ManufacturingAgTechHardwareRoboticsSeattle, US
Adam Iseman(Founder)inIlya Kelner(Founder)inAlex Neff(Founder)in
Riveter is a web data extraction and automation platform that searches, navigates, and retrieves specific information from the internet for teams across e-commerce, marketing, real estate, and other data-dependent industries. The platform uses AI to extract and classify data at scale, replacing manual research with automated workflows.
AI & Machine LearningData & InfrastructureDeveloper ToolsEnterprise SoftwareSaaSSan Francisco, US
Abigail Grills(CEO & Co-founder)in
Terapify is an online mental health platform that connects users with licensed psychologists for individual and couple therapy sessions, along with supplementary wellness content such as yoga classes and guided meditations. The service operates across Latin America and serves Spanish-speaking users seeking accessible virtual mental health care.
HealthtechMental HealthWellness & FitnessMexico City, MX
Juan Daniel Velez Santiago(Founder)inEduardo Velez Santiago(Founder)in
Portfolio company currently supported by Region Cuatro
Toku provides software for Latin American businesses to manage accounts receivable operations, including payment processing, retry logic for failed transactions, and customer notifications, allowing companies to improve cash collection efficiency.
Enterprise SoftwareFintechSaaSMexico City, MX
Francisca Noguera(Founder)inCristina Etcheberry(Founder)inEnzo Tamburini(Founder)in
Frequently asked questions
- What stage does Region Cuatro invest at?
- Region Cuatro invests at the Pre-Seed, Seed stages.
- What sectors does Region Cuatro focus on?
- Region Cuatro focuses on AI & Machine Learning, Sector Agnostic.
- Where is Region Cuatro located?
- Region Cuatro is headquartered in California, US.
Similar investors
Data Collective identifies and supports ambitious company founders developing technology-driven solutions. The firm focuses on companies using innovation to restore predictability in an unstable world, with demonstrated expertise across clean energy, gene therapy, sustainable agriculture, and machine learning applications in healthcare.
First Round is a venture capital firm that provided early funding to Notion, including writing the largest check in the company's 2013 seed round.
Foundation Capital is a venture investment firm that supports early-stage technology founders tackling challenging, regulated industries. The firm believes in backing technologists and entrepreneurs who approach established sectors with fresh perspectives and strong execution discipline.
A venture capital firm with $5 billion in assets under management that partners with founders from idea stage through exit, drawing on a team with an average of 15 years of collaborative experience.
Gelt VC is an early-stage venture capital firm that invests in pre-seed and seed-stage companies across multiple sectors and geographies. The firm focuses on markets with significant growth potential, ranging from artificial intelligence and deep technology to gaming and social commerce.