Creative Destruction Lab (CDL) — Full Portfolio

Copperstone Tech designs and operates HELIX robots, autonomous all-terrain vehicles equipped with sensor payloads to conduct surveys and data collection in extreme environments including mines, water bodies, and hazardous terrain while minimizing human exposure to dangerous conditions.

CleantechDeep TechHardwareRobotics

Co-investorsFOForesight Canada

Cordance Medical develops medical technology focused on diagnosing and treating patients with brain diseases, drawing on expertise from neurosurgery, neuroimaging, and biomedical engineering.

AI & Machine LearningBiotechDeep TechDigital HealthHealthtechMedical DevicesMountain View, US

RDRyan Dittamore(CEO)in

Co-investorsANAngel Physicians FundBEBeresford VenturesBLBlack Mountain VentuesSASamsung NextSHShanda GroupSMSmartGateVC+3 more

Builds AI intended to predict conflict/war.

Justin E. Lane(Founder)in

Co-investorsFIFinal Frontier (Space & Defence VC)RORockaway VenturesSISimpact VenturesZEZero Gravity Capital

Dalhousie University is a public university based in Nova Scotia, Canada, focused on teaching, research, and community engagement.

EdTechHalifax, CA

Deep Genomics develops AI-based biological foundation models to identify drug targets and design molecules, aiming to speed up drug discovery.

AI & Machine LearningBiotechDeep TechToronto, CA

BFBrendan Frey(Founder)inBOBrian O'Callaghan(Chief Executive Officer)inDJDavid Johnston(Chief Financial Officer)inCBClive Bertram(Chief Business Officer)inTMTom Masterson(Chief Operating Officer)inGHGreg Hoffman(Chief Scientific Officer)in

Co-investors1111.2 CapitalBLBloomberg BetaFUFuture VenturesKEKensington Capital Partners LimitedMAMagnetic VenturesSOSoftBank Vision Fund+2 more

Diffraqtion commercializes sub-diffraction imaging physics developed through DARPA and NASA programs for high-precision space domain awareness and exoplanet detection.

AI & Machine LearningDeep TechSpace TechSomerville, US

Johannes Galatsanos(Founder)inSaikat Guha(Co-founder)Dr. Saikat Guha(Co-founder)

Co-investorsCOCollaborative FundHEHEC Paris IncubatorMIMilemark Capital PartnersQDQDNL Participations

Eavor Technologies is a private geothermal energy company developing closed-loop geothermal technology.

CleantechClimate TechEnergyCalgary, CA

PAUL C. CAIRNS(Executive Officer, Director, Promoter)inJRJOHN REDFERN(Executive Officer)inJVJEANINE VANY(Executive Officer)inMAMATTHEW A. TOEWS(Executive Officer)inRYAN MICHALUK(Executive Officer)inDEREK NORMAN RIDDELL(Executive Officer, Director)

Co-investorsFEFelicis VenturesJAJapan Energy CapitalTHThird DerivativeVIVickers Venture PartnersBDBDC Capital CorporationBHBHP Ventures+3 more

Endeavor Composites develops proprietary nonwoven advanced composites technology targeting new markets with a focus on high production efficiency and sustainability.

Advanced ManufacturingCircular EconomyCleantechNew MaterialsKnoxville, US

Hicham Ghossein, Ph.D.(Chief Executive Officer)in

ESMT Berlin is an international business school in Germany offering degree programs, PhD programs, and executive education.

EdTechBerlin, DE

Co-investorsBUBusiness Angels Club Berlin-Brandenburg e.V.

FireSwarm develops autonomous ultra-heavy-lift drone systems and a mission coordination platform for wildfire suppression, logistics, resupply, and emergency operations in smoke, low-visibility, and remote terrain conditions.

AI & Machine LearningCleantechClimate TechDeep TechDefense TechRobotics

David Thanh(Founder / COO)inMelanie Anne Bitner(Founder)inAlex Deslauriers(Founder / CEO)Melanie Bitner(Founder / CMO)Juliet Jones(Fractional CFO)Christina Pattison(Program Management)in

Co-investorsBCBC CICE

HEC Montréal is a business school offering academic programs and training for students, faculty, and the broader community.

EdTechMontréal, CA

Icarus Robotics develops autonomous robots for space that use embodied AI, starting with human-in-the-loop control and learning from demonstration to handle tasks such as cargo handling and orbital construction.

AI & Machine LearningRoboticsSpace TechSan Francisco, US

EBEthan Barajas(CEO)inJPJamie Palmer(CTO)in

Co-investorsENEntrepreneur FirstHEHEC Paris IncubatorSOSoma CapitalTRTranspose Platform Management

Intella builds Mercury, software for continuous operational assurance of satellite fleets that correlates signals such as satellite telemetry, per-component degradation data, and AI detection to flag operational events and recommend actions to space operations teams.

AI & Machine LearningSaaSSpace Tech

IS-Wireless is a European deep-tech company that develops Open RAN-based private and public 5G/6G networks, including intelligent RAN controllers (RIC), for both industrial (Industry 4.0) and defense/tactical applications.

Deep TechDefense TechPiaseczno, PL

Dr. Sławomir Pietrzyk(President and Chief Executive Officer)Robert Cieloch(Chief Technology Officer)Kamil Pluskwa-Dąbrowski(Chief Legal Officer)Łukasz Bromirski(Chief Product and Revenue Officer)Łukasz Szarawara(Chief Financial Officer)

KA Imaging develops X-ray imaging technologies and systems, including dual-energy radiography, phase contrast micro-CT, and amorphous selenium detectors.

HardwareHealthtechMedical DevicesWaterloo, CA

KSKarim S. Karim(Chief Technology Officer (CTO), Co-founder)inSGSina Ghanbarzadeh(Co-founder & Design Team Lead)inAKAmol Karnick(President & CEO)inPTPhilip Templeton(Chief Medical Officer (CMO))in

Co-investorsFAFACIT (Fight Against Cancer Innovation Trust)INIn-Q-TelLALauder PartnersNONorthspring Capital Partners

Lodge builds fixed-wing airframes and deployable industrial manufacturing capacity, moving parts from prototype to production using the same suppliers, tooling, and manufacturing files.

Advanced ManufacturingDeep TechHardware

METHYS Dx develops liquid biopsy tests based on panels of methylation markers to characterize circulating tumor DNA (ctDNA) in biological fluids such as blood.

BiotechHealthtechMedical Devices

Metropolitan builds a zero trust, data-centric security platform that ingests sensor data at the edge in real time, protects it with two layers of quantum-safe encryption, and relays it peer-to-peer to authorized users and applications.

CybersecurityDeep TechDefense Tech

Thalmic Labs manufactures wearable armbands that detect electrical muscle signals to enable wireless control of computers and mobile devices.

ConsumerHardwareKitchener, CA

SLStephen Lake(CEO)inMBMatthew Bailey(Founder)inAGAaron Grant(Founder)Daniel Choi(Display Hardware Engineer)TATak Alguire(Manufacturing Quality Coop)in

Co-investorsY Y CombinatorACAcequia Capital (AceCap)FIFirst Round CapitalFOFormation GroupFUFundersClubGAGarage Capital+4 more

North Vector Dynamics is a Canadian defence technology company developing precision interception, autonomy, and advanced propulsion systems, including counter-UAS solutions and hypersonics.

Deep TechDefense TechHardwareCalgary, CA

PZPaul Ziadé(CEO)inPaul Ziade(Founder)

Co-investorsACACADEMY INVESTORAIAIN VenturesFEFeld VenturesNONorthside VenturesONOne 9 InvestmentsSISilent Capital+3 more

Northern Waves is a Swedish company that uses additive manufacturing (3D printing) to design and produce RF and microwave components such as waveguides, horn antennas, radomes, and antenna arrays.

Advanced ManufacturingDeep TechHardware

Pepe(CEO)Sara(COO)Omar(CTO)

Politecnico di Milano is an Italian university offering programs across schools of architecture and construction engineering, design, civil and environmental engineering, and industrial and information engineering.

EdTechMilan, IT

Propel Space develops spacecraft mechanisms and provides engineering support services including mechanical and electrical design, systems and program management, and space environmental testing for spacecraft programs.

Deep TechHardwareSpace Tech

Qtas develops a quantum-sensor-based microscopy platform, described as the world's smallest MRI, that detects, sorts, and recovers intact individual rare cells (such as circulating tumor cells and rare immune cells) directly from unprocessed biological samples like whole blood or spinal fluid.

BiotechDeep TechQuantum Computing

Co-investorsOVOVNI Capital

Seamore Tech works on water desalination technology aimed at improving the efficiency of freshwater production and reducing the harmful brine discharged into oceans by conventional desalination plants.

CleantechClimate TechDeep Tech

Sofia Delgado(Founder)in

Co-investorsFAFaber

Sigen AI develops a video integrity platform that turns live or recorded feeds into tamper-evident, cryptographically verifiable assets with object-level signing, role-based encryption, and real-time redaction.

AI & Machine LearningCybersecurityData & InfrastructureDefense TechDeveloper ToolsVancouver, CA

Co-investorsSFSFU VentureLabsTETechstars

Stratotegic develops navigable High-Altitude Platform Station (HAPS) stratospheric balloon systems with autonomous flight control and navigation, providing persistent intelligence, surveillance, and reconnaissance (ISR) and communications augmentation for defence, government, commercial, and research customers.

Deep TechDefense TechSpace Tech

TakeMe2Space builds satellite infrastructure for orbital compute, enabling data processing closer to the source in space.

AI & Machine LearningData & InfrastructureDeep TechHardwareSpace Tech

RKRonak Kumar Samantray(Founder)in

Co-investorsCHChiratae VenturesHEHEC Paris IncubatorARArtha Venture FundSESeafundUNUnicorn India Ventures

Texas A&M University is a public university that provides higher education across colleges and schools in fields such as engineering, medicine, law, business, agriculture, and the arts.

EdTechCollege Station, US

Thistle builds man-portable robotic weapon stations that detect, track, and neutralise incoming FPV and small drones at close range using edge AI and in-service weapons, with a human authorising each engagement.

Defense TechHardwareRoboticsTallinn, EE

Totex builds an AI-powered all-in-one home energy system that combines HVAC heating and cooling, water and pool heating, EV charging, energy storage, and backup power in a single unit.

CleantechEnergyHardware

uc2c.ai develops software for high-hazard industrial plants that connects a site's existing records—safety studies, change records, incident reports, drawings, procedures, and work history—into a single view of risk and ranks risk-reduction actions.

AI & Machine LearningEnterprise SoftwareSaaS

Bocconi is a university based in Milan, Italy, offering higher education and publishing academic content such as its viaSarfatti25 magazine.

EdTechMilan, IT

University of Tartu is Estonia's largest and oldest university (founded 1632), offering more than 140 degree programs and 1,200 continuing-education courses along with research-based education and doctoral study.

EdTechTartu, EE

The University of Washington is a public research university that conducts academic research and offers public events and programs across the arts, humanities, sciences, and social sciences.

EdTech

Co-investorsCHChris And Heidi Stolte

Vellex Computing develops on-device AI training technology that enables edge devices such as satellites, robots, and drones to learn and adapt continuously at milliwatt power levels without cloud retraining.

AI & Machine LearningDeep TechHardware

Palak Jain, PhD(CEO & Co-Founder)inJason(Product Engineer & Co-Founder)

Co-investorsCOCollaborative Fund

VXB Aerospace develops software using generative capabilities to help engineers design custom components involving complex multi-physics, such as antennas, electronics, and plasma propulsion.

Advanced ManufacturingAI & Machine LearningDeep TechDefense TechHardwareSpace TechEveleigh, AU

ARAlexander Ryan(CEO & Co-Founder)in

Co-investorsFUFulcrum VentureHEHEC Paris IncubatorINInvestible Climate Tech FundTETechstarsJEJelix Ventures