Medical Devices Startups

ZEISS Semiconductor Manufacturing Technology provides optics and manufacturing solutions for microchip production, including lithography optics and photomask systems for semiconductor manufacturers worldwide. The company's technologies enable the production of smaller, more efficient, and cost-effective microchips used across electronics, communications, and energy sectors.

1 investor

Zeph develops a digital health platform with clinical-grade sensors to help patients manage respiratory conditions like COPD through home-based rehabilitation and evidence-based exercises. The platform serves patients, clinicians, and care teams seeking better respiratory health management.

1 investor

Zepto develops a targeted liquid biopsy platform for infectious disease diagnostics, offering plasma-based molecular testing through its CLIA reference laboratory and an integrated sample-to-result platform for use in hospital laboratories. It also provides analytical performance and reference testing support to help diagnostics obtain FDA clearance.

1 investor

Zergo produces a urine-based test designed to assist women with fertility and conception.

1 investor

Zest Dental Solutions designs, manufactures, and distributes dental care solutions including implant anchors, restorative materials, and diagnostic equipment. The company serves dental practitioners and patients across the full spectrum of dental care, from natural tooth preservation to complete tooth replacement.

1 investor

Zetagen develops molecular therapies, including its ZetaMet (Zeta-BC-003) drug, that aim to suspend cancer, inhibit pain, and regenerate bone in patients with metastatic and primary bone cancers. The locally administered treatments are adjunctive to other cancer therapies and target patients living with bone metastases, primarily in the United States.

1 investor

Zeteo Tech develops mass spectrometry and detection technologies for biomedical, defense, and security applications, including bioaerosol detection and breath analysis. The company works across areas such as TB and breath diagnostics and defense/security programs.

1 investor

ZetrOZ Systems develops wearable, non-invasive bioelectronic ultrasound devices that deliver sustained acoustic medicine (sam®) to treat acute and chronic musculoskeletal conditions, supporting tissue recovery and pain relief. The company serves the sports medicine and healthcare market and manufactures its sam® product line in the United States.

1 investor

Zeus develops sleep improvement devices, including anti-snoring and obstructive sleep apnea management products, based on proprietary TESLA technology developed through collaboration with medical institutions and researchers.

1 investor

ZEV Biotech develops IRIS®, an integrated molecular diagnostics platform combining reagents, hardware, and software that can test multiple genomic biomarkers across small batches of patient samples. It targets laboratories, research institutions, and hospitals, aiming to make molecular diagnostics accessible in decentralized settings, with a focus on Latin America.

1 investor

Zevra Therapeutics develops and commercializes rare disease treatments, including therapies for Niemann-Pick disease type C and urea cycle disorders. The company serves patients with inherited metabolic and genetic disorders through FDA-approved pharmaceutical products.

1 investor

ZIBRIO develops a balance assessment technology using machine learning to measure postural stability through a one-minute standing test, designed for both self-administration and clinical settings to identify fall risk in older adults. The company serves healthcare providers and older adults seeking fall prevention and balance monitoring.

1 investor

Zidan Medical develops an endobronchial radiofrequency ablation system, using a small flexible RF catheter with "virtual electrode" forward-throw technology to deliver targeted, temperature-controlled energy to destroy lung lesions. The device is intended for treating lung cancer patients.

1 investor

Ziehm Imaging develops mobile medical imaging systems, such as C-arm imaging technology, used in healthcare facilities worldwide. It provides the imaging hardware along with clinical and technical support for healthcare providers.

1 investor

Zilia develops a medical imaging platform that measures biomarkers in the eye to enable early detection of preventable blindness, including glaucoma and diabetic retinopathy. The company leverages spectroscopy and artificial intelligence to provide non-invasive assessment of ocular metabolic activity.

1 investor

ZimVie provides dental implant solutions, including full-arch immediate load implant systems, designed to improve patient smiles, function, and confidence. The company serves dental professionals and patients in Canada.

1 investor

Zahnarzt-Helden offers brand-independent advisory and sales for dental practice equipment, including intraoral scanners, X-ray devices (OPG/DVT), 3D printing systems, and chairside restoration workflows. It serves dental practices in Germany with consultation, installation, financing options, and after-sales support.

1 investor

ZOLGENSMA is a gene replacement therapy that delivers a working SMN gene to treat spinal muscular atrophy (SMA), a rare genetic disease affecting motor nerve cells. The treatment is designed for infants and children with SMA to help restore survival motor neuron protein production.

1 investor

Zonova Tech develops Z-ROS, an antimicrobial technology engineered directly into medical or other devices to provide built-in protection against microbes.

1 investor

ZSFab manufactures porous titanium spinal implants featuring hierarchical lattice architectures designed to support bone integration and reduce subsidence risk in cervical and lumbar fusion procedures. The InterConnect™ system combines optimized porosity, surface texturing, and biomimetic structural design for orthopedic surgeons and spinal fusion patients.

1 investor

ZSX Medical develops surgical wound closure devices, including its lead product Zip-stitch, a clinical-stage device designed to assist surgeons with closure procedures more efficiently.

1 investor

Zuno Medical makes sealed sterilization containers for medical instruments that block microorganisms without relying on porous barriers or filters, maintaining a barrier even with residual moisture. The product is aimed at healthcare sterilization and surgical instrument processing.

1 investor

ZygoFix develops minimally invasive fixation solutions for joint stabilization and fusion procedures, targeting the ambulatory surgery center market. The company was founded by orthopedic experts and engineers specializing in medical device development and spinal implant technology.

1 investor

Zylem Biosciences develops Metabolic Redox Modulators (MRMs), a patented platform of drug candidates targeting the SR-B1 receptor to treat cancer, cardiovascular disease, and other age-related conditions. The company leverages fifteen years of research from Northwestern University to create therapeutics that induce metabolic dysfunction in disease cells while sparing healthy cells.

1 investor