Digital Health Startups

Universal DX develops blood-based tests for early cancer detection, with a focus on colorectal cancer screening. The company runs clinical studies through a network of hospitals and gastrointestinal clinical teams across the U.S. and Europe.

1 investor

Universitätsklinikum Leipzig is a university hospital providing clinical care, outpatient services, and medical research and education in Leipzig, Germany.

1 investor

Unpluq provides tools to help users feel more present and engaged with life by reducing unwanted digital interruptions and distractions. The platform focuses on creating quieter, more intentional digital experiences for individuals seeking to regain presence in their daily lives.

1 investor

Unravel Bio uses computational drug discovery and advanced animal models to accelerate pharmaceutical development with lower cost and risk. The company serves biopharma partners, foundations, and patients seeking treatments for rare and complex diseases.

1 investor

Unyte Health develops evidence-based listening therapies — including the Safe and Sound Protocol, Rest and Restore Protocol, and Integrated Listening System — that use sound-based interventions to support nervous system regulation. Its programs and MyUnyte platform are used by therapists, clinicians, educators, and wellness professionals to help clients build resilience and improve therapeutic outcomes.

1 investor

UpDoc builds agentic clinical AI that connects with patients between appointments to gather structured health data, coordinate with care teams, and deliver physician-prescribed interventions for chronic disease management. It is designed for enterprise health systems, providers, and payers, with integration into EHR environments and clinical workflows.

1 investor

Upfront develops healthcare solutions that activate patients and improve clinical, financial, and operational outcomes for providers. The company combines healthcare expertise, technology, and behavioral science to address healthcare challenges.

1 investor

UPGUYS is Canada's leading digital health platform providing testosterone replacement therapy, hormone optimization, and treatments for erectile dysfunction and hair loss through licensed Canadian practitioners and pharmacies.

1 investor

Uplevel Digital is a full-service digital agency that provides digital marketing and web development services to businesses across various industries. The company delivers strategy, design, and technical solutions aimed at growing clients' online presence and business growth.

1 investor

Uplift Labs offers an AI-powered computer vision platform that uses an iPhone for 3D motion capture and biomechanical movement analysis, replacing expensive motion-capture labs. It serves professional and youth sports teams (including MLB, NBA, and NCAA organizations), healthcare/rehabilitation providers, and media broadcasters for athlete evaluation, injury-risk detection, player development, and fan engagement.

1 investor

Upliv provides administrative management software for self-managed home care, helping people with disabilities organize scheduling, timesheets, records, and compliance in one platform. The solution reduces the administrative burden of independent living so users can focus on their daily life rather than logistics.

1 investor

UPMC is a regional healthcare provider that invests in community health through charity care, free and subsidized health programs, and support for seniors, veterans, and food-insecure populations.

1 investor

Upmedic develops software tools to simplify clinical documentation and reporting workflows for physicians. The platform targets healthcare professionals, particularly radiologists and other medical specialists seeking to improve operational efficiency.

1 investor

Upperline Health operates a multispecialty medical practice network offering podiatry, endocrinology, and primary care clinics across the United States, using a value-based, whole-person care model. Through its Upperline Plus offering, it provides patients with 24/7 access to a dedicated care team for coordinated support in the clinic and at home, and partners with providers who previously ran independent practices.

1 investor

Upswing Health offers virtual musculoskeletal care for muscle and joint pain, combining an AI-powered symptom assessment tool with licensed athletic trainers and board-certified orthopedic physicians. It provides remote injury guidance, virtual rehabilitation programs, and coordinated referrals to physical therapists, imaging centers, or orthopedic specialists when in-person care is needed.

1 investor

1 investor

Care for Kids (formerly Urgent Care for Kids) operates pediatric-focused urgent care clinics offering after-hours care in kid-friendly settings with extended hours and no appointment required. It serves children and their parents, with clinics in Texas.

1 investor

UrgentIQ provides an AI-native electronic medical record and practice management system designed specifically for urgent care centers, handling patient intake, clinical documentation, coding, and billing. The platform serves urgent care center staff and operators seeking to reduce administrative burden and improve patient outcomes.

1 investor

U.S. Urology Partners provides urology and radiation oncology services, including clinical research and advanced radiation treatment programs.

1 investor

Upstream Rehabilitation operates a network of outpatient physical therapy clinics across the United States, providing rehabilitation care to patients. The company also partners with and acquires independent physical therapy practices.

1 investor

USHP develops technology and care solutions for cardiovascular health, serving physicians and medical practices. The company focuses on integrating innovative tools to improve heart care delivery and patient outcomes.

1 investor

USHV is a physician-led management services organization serving independent cardiology practices across the United States, providing shared infrastructure including electronic medical records, analytics, ambulatory surgery centers, and administrative support while preserving local clinical leadership and practice independence.

1 investor

US Orthopartners (USOP) is an integrated orthopaedic care platform that provides a full continuum of musculoskeletal treatment through a network of physician-owned practices, clinics, and hospitals. It partners with orthopaedic physicians and practices, offering value-added services such as compliance support and performance benchmarking while practices maintain clinical autonomy.

1 investor

Us2.ai provides FDA-cleared AI software that automatically analyzes echocardiograms and generates structured clinical reports in real time. The platform detects cardiac diseases including amyloidosis, aortic stenosis, heart failure, and valvular disease, integrating seamlessly with existing ultrasound devices and hospital infrastructure.

1 investor