Deep Tech Startups

Open Bionics develops 3D-printed bionic hands called the Hero Arm, designed to be affordable, functional, and aesthetically appealing alternatives to traditional prostheses. The company serves individuals with upper limb differences and limb loss, operating in the medical devices and assistive technology space.

3 investors

OpenLight Photonics develops photonic integrated circuits and systems for data center, telecommunications, and sensing applications. The company serves enterprises and infrastructure providers requiring high-speed optical connectivity and signal processing.

3 investors

Opo develops bio-based ingredients and cell lines for cosmetic, medical, and cultivated meat applications using synthetic biology and biomanufacturing. The company supplies high-performance biomaterials and multi-species cell banks to biotech and food production customers.

3 investors

Optimeos develops a nanoparticle-based drug formulation and delivery platform (CINCs and LINCs) for complex biologics including mRNA, DNA, peptides, and proteins, targeting rare diseases, immunology, and metabolic conditions such as obesity. Its technology enables intracellular and long-acting delivery for pharmaceutical and biotech partners addressing challenges like tissue targeting and dosing profiles.

3 investors

Opus Genetics is a clinical-stage ophthalmic biopharmaceutical company developing therapies for inherited retinal diseases (IRDs) and other retinal and refractive disorders. It focuses on genetic medicine aimed at preserving and restoring vision for patients with rare eye conditions.

3 investors

OrangeQS provides automated testing and characterization equipment and software for quantum chips with several to hundreds of qubits. The company serves quantum hardware developers in industry and research with turnkey solutions that accelerate the quantum chip development cycle.

3 investors

Orbit works on complex problems in neuroscience.

3 investors

Orbital builds commercial AI compute infrastructure in Low Earth Orbit, deploying satellite-hosted GPU payloads with high-bandwidth ground links for AI inference. The company positions space-based data centers as a way to bypass terrestrial power grid constraints.

3 investors

Orbital Paradigm operates a logistics platform that connects shippers, carriers, and stakeholders to streamline global freight operations with real-time tracking and process automation. The platform serves businesses of all sizes seeking to simplify international shipping and logistics management.

3 investors

OrganoidSciences develops organoid-based regenerative therapeutics and evaluation solutions, operating dedicated GMP manufacturing facilities for cell/organoid drug production. Its lead program ATORM-C is an organoid therapy for inflammatory bowel disease, with clinical development across Korea, the US, and Europe.

3 investors

Oricell Therapeutics (原启生物) is a clinical-stage biopharmaceutical company developing cell therapies, including CAR-T products targeting GPRC5D for relapsed/refractory multiple myeloma and GPC3 for advanced liver cancer. Based in Shanghai, it builds proprietary antibody and CAR platforms (OriAb, OriCAR) to create cancer immunotherapies for unmet oncology needs such as liver, gastric, pancreatic, biliary, and ovarian cancers.

3 investors

Oriient provides indoor location technology that enables retailers, hospitals, and smart buildings to measure and navigate indoor spaces without requiring dedicated hardware. The platform makes indoor environments measurable and actionable for teams to improve movement visibility and space utilization.

3 investors

Oriole Networks develops PRISM, an all-optical circuit-switched networking fabric that uses photonic switching to connect GPUs at scale for AI/ML and high-performance computing data centers. The technology aims to increase GPU utilization and reduce network power consumption for AI training and inference workloads.

3 investors

OrsoBio develops therapies to restore energy homeostasis in patients with severe metabolic disorders, drawing on biological research including human liver organoids and insights from metabolic pathways. The company targets patients with metabolic diseases through precision therapeutic approaches.

3 investors

Orthofuse designs orthopedic implants and surgical systems using 3D printing technology for trauma and spinal procedures. The company targets orthopedic surgeons and hospitals to improve surgical outcomes and reduce procedure complexity.

3 investors

OSC designs and deploys customized simulation centres and virtual prototypes for offshore and marine operations, including vessel training, subsea operations, and heavy lift installations. The company serves operators in oil, gas, renewable energy, and decommissioning sectors across multiple continents.

3 investors

OSSTEC is a medical device startup developing a 3D-printed biomimetic knee implant intended for use in hospitals. Founded out of Imperial College London, the company focuses on orthopedic implants aimed at improving patient mobility and quality of life.

3 investors

Othram provides forensic DNA testing and analysis infrastructure for law enforcement agencies, medical examiners, and missing persons organizations to identify human remains and resolve cold cases. The company offers in-house DNA processing, genealogical analysis, and a DNA database (DNASolves) to match forensic evidence with potential relatives.

3 investors

oVRcome is a New Zealand-based digital mental health platform using virtual reality technology to treat phobias and anxiety disorders. The company aims to reduce the treatment gap by providing accessible, affordable clinical interventions delivered through smartphone apps.

3 investors

Oxford Science Enterprises is a venture-building investment firm, working in partnership with the University of Oxford, that funds and creates companies based on scientific research from Oxford, Harwell and Culham. It provides capital and company-building support to spin ventures out of academic breakthroughs across deep science fields.

3 investors

OXMIQ Labs is a Silicon Valley semiconductor startup developing AI chips, built by a team of GPU and AI architects. The company is building across the US and India.

3 investors

Paradox Immuno develops a platform for discovering therapies targeting protein misfolding diseases, leveraging proprietary research and lead identification technology to address rare conditions with no existing treatments.

3 investors

Parasma develops algorithms and infrastructure to train living neural systems for computation, aiming to make advanced AI far more energy-efficient and accessible by leveraging biological neurons as programmable compute. The company serves organizations seeking to reduce the energy footprint and hardware costs of AI systems.

3 investors

Paratus Sciences is a drug discovery company that uses AI-powered methods to identify first-in-class medicines by studying evolutionary traits, targeting serious diseases where current therapies are inadequate. The company combines computational discovery with drug development expertise to create new therapeutic programs.

3 investors