Deep Tech Startups

Iris Light develops photonic inks based on nanomaterials that enable integration of light-emitting and light-detecting components directly onto silicon wafers, addressing manufacturing bottlenecks in silicon photonics and infrared imaging. The company targets applications including optical communications, medical devices, autonomous vehicle LiDAR, and chemical/biological sensors.

3 investors

Iris Medicine is an early-stage biotech developing RNA therapies based on its small binding RNA (sbRNA) platform, which uses cooperative RNAi binding to selectively silence mutant genes carrying expanded pathologic repeat sequences while preserving healthy alleles. Its lead programs target repeat expansion disorders including Huntington's Disease, C9orf72 ALS, and the Spinocerebellar Ataxias.

3 investors

Irradiant operates a 3D nano-optics and photonics foundry, using flexible 3D nano-fabrication and lithography to manufacture optical and photonic components such as metalenses, optical interconnects, and integrated free-space optical microsystems. It works with engineering and hardware companies to prototype and mass-produce miniaturized light-based components for sensing, imaging, display, computing, and connectivity.

3 investors

Jacobio is a biopharmaceutical company developing novel oncology therapeutics, focusing on next-generation antibody-conjugated drugs including ATDCs, ISACs, and AOCs to treat cancer patients.

3 investors

Jaia Robotics develops autonomous aquatic drones and software that enable safe, simplified data collection from water environments. The company serves customers including military, government, research, and commercial organizations needing cost-effective marine observation capabilities.

3 investors

Janux Therapeutics is a clinical-stage biotech company developing precision-engineered immunotherapies for the treatment of cancer and autoimmune diseases. It uses its TRACTr, TRACIr, and ARM platforms to engineer drug candidates intended to direct the immune system against disease while limiting systemic safety issues.

3 investors

JetCool designs direct-to-chip liquid cooling modules that use microconvective cooling technology to reduce energy consumption, water usage, and carbon footprints in high-power electronics. It serves hyperscale and enterprise data center customers deploying AI and high-performance computing systems, and operates as a Flex company following its 2024 acquisition.

3 investors

Jua develops an AI agent that models physics and optimization to simulate and improve physical systems at scale, starting with energy pricing and grid optimization across global markets, and expanding to materials discovery, aerospace design, and drug development.

3 investors

JuliaHub provides a cloud-based SaaS platform for scientific and technical computing, offering development, deployment, and scaling capabilities for Julia programs along with specialized tools for pharmaceutical modeling, multi-physics simulation, and circuit design. It serves data scientists, engineers, and researchers across academia and industry.

3 investors

KAICO produces difficult-to-express proteins using silkworm technology for use as pharmaceuticals, diagnostic tools, and reagents. The company partners with pharmaceutical manufacturers to develop new drugs using its core platform for protein production in silkworms.

3 investors

Kilsar provides an AI-powered platform that captures and enriches technical documentation for industrial operations, serving aerospace, heavy equipment, manufacturing, and utilities sectors. The platform enables organizations to preserve expert knowledge, create standardized assembly guidance, and improve technician onboarding and maintenance execution across complex systems.

3 investors

Kimia is a therapeutics company developing new drugs through its ATLAS platform, working with partners in the pharmaceutical and biotechnology industries. It focuses on improving outcomes for patients.

3 investors

Kinitics Automation develops motion control actuators and pumps using shape memory alloy technology for applications in automotive, power generation, and industrial sectors.

3 investors

Korsana develops technology to deliver large-molecule biologic drugs across the blood-brain barrier using transferrin receptor shuttling, aimed at treating neurodegenerative diseases such as Alzheimer's. Its approach uses antibody engineering to enable therapies with meaningful central nervous system exposure delivered subcutaneously.

3 investors

GenKan is a manufacturing shop-floor monitoring system that uses installed sensors (including RFID) to automatically capture production data, making processing costs, material costs, and electricity consumption visible for high-mix, low-volume manufacturers. It also provides cost-management consulting support, from actual cost analysis to KPI setting, aimed at Japanese factory operators.

3 investors

KronosAI provides AI-powered multiphysics simulation software for engineers, combining frontier AI models with best-in-class numerical solvers to enable autonomous, high-fidelity simulations through natural language interfaces. The platform serves engineering teams across photonics design, geophysical exploration, and other physics-intensive domains.

3 investors

Kvantify develops software that runs on both quantum computers and classical computing architectures (CPU/GPU) to solve chemistry and biology problems for molecular and drug discovery. Its algorithms distribute calculations across quantum and classical compute resources in high-performance computing environments to accelerate the discovery of disease-curing molecules.

3 investors

Kyber builds real-time control infrastructure that reduces network latency to single-digit milliseconds, enabling operators to remotely control robots, drones, and autonomous systems with minimal delay. The platform synchronizes video, audio, control inputs, and telemetry for applications ranging from surgical robotics to warehouse operations across multiple industries.

3 investors

Ladder Bio (formerly ThirdLaw Molecular) develops Spiroligomer molecules, a class of synthetic, modular fused-ring compounds designed for highly selective binding to target proteins, along with computational design tools for targeted drug discovery. The platform is aimed at creating therapeutics and diagnostic tests as synthetic alternatives to peptides and antibodies.

3 investors

Lam Research designs and manufactures semiconductor processing equipment used in the fabrication of computer chips. The company serves chipmakers globally with deposition, etch, and advanced packaging solutions for next-generation semiconductor production.

3 investors

LastMile AI is building what it calls a "cognitive computer," an AI-native system designed to maintain context about a person, team, and organization, connect to authorized tools, and orchestrate tasks alongside humans and AI. It targets teams and organizations seeking to make generative AI useful and reliable for their work.

3 investors

Latent Technology develops AI-driven tools and technology for game creators and players to design and experience virtual worlds. The company applies deep learning to reinvent game development processes and player experiences.

3 investors

Lattica works on accelerated encrypted compute technology.

3 investors

Leaf Space operates a ground station network providing Ground Segment-as-a-Service infrastructure for satellite operators, enabling flexible access to satellite communications without owning ground infrastructure. The company serves commercial constellations, institutional missions, and defense programs globally through 40+ ground stations.

3 investors