Deep Tech Startups

DeepSim provides a physics simulation platform that automates complex setup procedures to accelerate engineering design workflows. The platform uses GPU-accelerated computation to enable engineers to run simulations at unprecedented scale without sacrificing accuracy.

2 investors

Deepwave Digital builds RF (radio frequency) intelligence products, including its AirStack software suite for managing AI and signal processing at the edge and its AIR-T software-defined radio hardware for wireless deep learning. Its products serve applications in avionics, autonomous systems, industrial IoT, 5G/6G communications, and electronics testing.

2 investors

DEFCON AI builds AI-powered execution platforms for complex operations under uncertainty, serving defense, infrastructure, supply chain, manufacturing, and healthcare sectors. The platform uses artificial intelligence and mathematical optimization to help organizations plan, evaluate scenarios, and make decisions in dynamic environments.

2 investors

Dennisson develops AURAFLEX, a light-activated artificial muscle actuator platform that provides slim, silent linear motion without gearing. The technology targets humanoid robotics as its lead market, along with wearables, prosthetics, automotive, and medical devices.

2 investors

Destinus develops the Hornet Block 2, a mobile canister-launched dual-role system that intercepts subsonic aerial threats and conducts precision strikes against maritime and ground targets. It uses AI-coordinated swarm operations with EO/IR and radar guidance for autonomous engagement in GNSS-denied environments.

2 investors

Kryla is a distributed saturation cruise system designed for high-volume strike and air defence saturation, using coordinated multi-effector engagement and time-on-target synchronization to overwhelm air defences in contested environments. It carries a 50 kg payload with a range of 800+ km and can be deployed via air-drop pallet or booster-assisted canister launch from a 20-ft container.

2 investors

DiffuseDrive builds synthetic data generation tools for physical AI systems, using its Atlas product to create real-world-grade scenarios from existing data for model training, validation, and edge case testing. It serves developers of physical AI across land, air, sea, and space applications.

2 investors

DINYA DNA builds an enzymatic "Exponential Synthesis" platform that directly synthesizes long, complex double-stranded DNA up to 5kb from a pre-built material library without oligo assembly, delivering custom sequences in 3-10 days. It serves scientists through an Early Access synthesis service, planned to launch in 2026, in the synthetic biology and gene synthesis space.

2 investors

Dipole Labs develops photonic (optical) hardware intended to serve as the optical layer for AI and quantum computing infrastructure, aiming to overcome the physical limits of silicon in speed, density, and efficiency. The company targets AI and quantum infrastructure providers.

2 investors

Diraq develops quantum computers based on modified silicon transistors, aiming for utility-scale quantum processing units the size of a single data-center rack. The company focuses on scaling to millions of qubits with error-corrected operations.

2 investors

Direct Kinetics (DKS) develops radioisotopic batteries based on beta-emitting isotope power sources, designed to provide continuous power for decades in an ultra-light form factor. The batteries target applications such as CubeSats, IoT sensors for asset tracking, and communications systems across land, sea, and space environments.

2 investors

DISC Alloys develops metal manufacturing and materials technology aimed at aerospace, defense, and high-performance industrial applications. The company applies materials science and advanced manufacturing methods to produce components for these sectors.

2 investors

Dispelix develops and supplies transparent waveguides that function as see-through displays for consumer and enterprise augmented reality devices. The company manufactures custom waveguide display components for high-volume and high-value AR markets through carefully vetted production partners.

2 investors

Distributed Spectrum builds software for radio spectrum management that combines machine learning, signal processing, and embedded systems. The company serves stakeholders in the radio domain with modular, flexible solutions positioned between low-cost hardware and expensive legacy systems.

2 investors

Particella, Inc. (formerly DNAlite Therapeutics) is a preclinical biotechnology company developing an oral lipid nanoparticle platform to deliver nucleic acids, such as mRNA, to the intestinal epithelium. It focuses on oral mRNA medicines.

2 investors

DNA Script develops enzymatic DNA synthesis technology, offered through its SYNTAX platform, that lets labs produce high-quality ssDNA oligos in-house and overnight. It serves research and life sciences customers including CROs, core facilities, biotech and pharma companies, and government agencies.

2 investors

Domaille Engineering, founded in 1990, provides precision machining and fiber optic solutions, including custom machining services and fiber optic equipment. It works with customers as an engineering partner to advance their technologies.

2 investors

Dorian Therapeutics was a biotechnology startup developing senoblockers, drugs designed to rejuvenate cells and tissues by targeting aging-related mechanisms. Acquired by Altos Labs.

2 investors

Dotomics builds foundation models for biology using AI and machine learning. The company serves researchers and organizations in the biotechnology and life sciences sectors.

2 investors

DSP Concepts develops Audio Weaver, a real-time embedded audio processing platform for designing, deploying, and managing audio across chipsets and products. It serves device makers in automotive, personal/wearable devices, conferencing, robotics, and smart home markets, with support for multicore SoCs and machine learning-based audio.

2 investors

Dunad Therapeutics is a biotech company developing oral small-molecule medicines using a covalent chemistry discovery platform to target neurodegenerative diseases such as ALS, Parkinson's disease, and FTD. Its programs aim to clear disease-driving proteins like toxic TDP43 to slow disease progression for patients and their families.

2 investors

Dynamic Biosensors develops the heliX biosensor instruments and switchSENSE and single-cell Interaction Cytometry (scIC) technologies for characterizing molecule-molecule and molecule-cell interactions and binding kinetics. Its instruments serve researchers in drug discovery and life sciences studying biophysical molecular interactions; the company was acquired by Bruker in 2024.

2 investors

Dynamic Dimension Technologies (DDT) builds engineering and software solutions—including simulation tools, robotics systems, and data solutions—for government and commercial clients, with a track record supporting the U.S. Navy, Army, and Air Force. Its work spans defense and industrial applications such as autonomous systems, factory automation, and Industry 4.0.

2 investors

Ebenbuild develops personalized, predictive digital twins for patients with severe illness, using computational models grounded in physics, physiology, biochemistry, and disease mechanisms. The company applies this digital twin technology to healthcare and life sciences to support more individualized and efficient patient care.

2 investors