Deep Tech Startups

Digzyme develops novel enzymes and bioprocesses to order, providing enzyme libraries, sample supply, IP licensing, and support for scale-up, commercialization, and regulatory approvals. It serves industrial clients seeking custom enzyme solutions in the biotech sector.

4 investors

FLOSFIA develops power semiconductor devices based on corundum-structure gallium oxide (α-Ga₂O₃), a material originating from Kyoto University in Japan, using its proprietary water-based "MISTEPITAXY" mist deposition process to achieve lower loss than SiC at silicon-level cost. It targets applications starting with small power supplies and expanding to industrial equipment, power infrastructure, and mobility including electric vehicles.

4 investors

Gaianixx develops, manufactures, and sells crystalline thin-film technology, including its "multifunctional intermediate film" and epitaxial materials based on a "dynamic lattice matching" mechanism researched at the University of Tokyo. The company aims to apply this materials technology to the semiconductor industry.

4 investors

gumi is a Japanese entertainment and blockchain company that develops mobile online games and operates digital asset and blockchain-related businesses through multiple subsidiaries across Japan, Asia, and North America.

4 investors

Jij is a startup founded by experts in mathematical optimization and quantum technology, providing software services such as the "JijZept" series that support the process from building mathematical optimization models to implementation. It also offers project support and talent development services, targeting a range of industries with a focus on the energy value chain, on a global basis.

4 investors

LINEA Innovations is a fusion energy company developing commercial reactors based on advanced-fuel fusion reactions and related technologies. Founded in 2023 and based in Tokyo, Japan.

4 investors

MOLCURE uses AI models trained on large experimental datasets to design molecules and accelerate drug discovery, working in collaboration with pharmaceutical partners. Its multidisciplinary team of machine learning scientists, biochemists, and bioinformaticians focuses on antibody and drug design.

4 investors

Photo Electron Soul develops and manufactures electron beam generation devices and components for research and industrial applications. The company is based in Japan with headquarters in Nagoya and operates development facilities in collaboration with Nagoya University.

4 investors

RICOS develops AI-powered simulation technology that combines computational analysis with machine learning to help manufacturers identify and visualize design and development challenges in product creation. The company serves manufacturing and product development teams across industries.

4 investors

IWAYA INC. develops high-altitude manned balloons, pressurized cabins, life support systems, and related equipment to carry people to the stratosphere for space viewing. The company also conducts research on unmanned, zero-pressure, super-pressure, and hydrogen balloons, and completed a manned flight above 20 km altitude in Japan in 2024.

4 investors

4Paradigm conducts research in AutoML and artificial intelligence technologies, partnering with universities and research institutions globally to advance AI applications across industries.

4 investors

Holoway develops precision surface-shape measurement instruments based on its own digital holography technology, offering measurement solutions for lab experiments, offline quality control, and inline/in-process measurement. Its systems measure flatness at nanometer resolution over large areas in a single shot without focusing, using a non-contact, non-destructive method.

3 investors

PRISM BioLab is a biotechnology company that develops PepMetics, a proprietary drug discovery platform of small molecules designed to mimic α-helix or β-turn peptides, aiming to target proteins previously considered "undruggable." The company maintains a screening library of over 20,000 compounds and partners with pharmaceutical firms on drug discovery programs.

3 investors

Intrinsic Semiconductor Technologies develops resistive random-access memory (RRAM) technology for non-volatile memory applications, enabling faster data access and write speeds with lower power consumption. The company's memory solutions target microcontrollers and edge AI applications in chip manufacturing.

3 investors

1s1 Energy develops materials innovations for green hydrogen production and utilization, targeting energy providers and utilities seeking low-cost, reliable decarbonization solutions. The company focuses on electrolysis stack technology and boron-based materials to enable hydrogen production at scale.

3 investors

2D Photonics develops graphene-integrated photonics technology for optical transceivers and interconnects used in data-intensive applications such as generative AI workloads. Its architecture aims to deliver high bandwidth density, wavelength-independent operation, and low power consumption while remaining compatible with silicon foundry manufacturing.

3 investors

310 AI develops generative AI foundation models for biology, including a molecular programming model that generates protein sequences from text descriptions of protein function. The company works toward making programmable biology a practical tool for solving real-world problems.

3 investors

4M offers a utility AI platform that aggregates and validates public utility records into a single comprehensive utility map for infrastructure project planning, design, and pre-construction. It serves project teams, designers, and field crews with utility conflict analysis, on-surface object detection, and data exports to GIS and CAD formats.

3 investors

4Point AI develops a Spatial Intelligence platform that provides geological insights for subsurface decision-making. The platform serves investors, mining operators, and governments by delivering decision-grade analysis for mineral discovery and earth science applications.

3 investors

4t2 Sensors develops fluid sensing technology aimed at providing measurement accuracy and insight in fluid analysis.

3 investors

A-SEEDS is a Shinshu University spin-out developing non-viral gene-modified immune cell therapies, including non-viral CAR-T cell products, to treat pediatric and young-adult cancers, including solid tumors, that lack effective treatments. The company focuses on advancing basic research through non-clinical development into clinical application of these cancer cell therapies.

3 investors

Abacus Power is developing power delivery and conversion technology for AI datacenters, focused on high step-down, high-efficiency, high-density conversion. The company is currently in stealth mode.

3 investors

Accelleran develops software for private 4G/5G radio access networks, including O-RAN compliant components for building and testing private cellular networks. The company works with partners such as Amarisoft on 5G network infrastructure and testing.

3 investors

Achira builds molecular world models that blend geometric deep learning, physics, and quantum chemistry to advance drug discovery and materials design. The company combines AI and physical simulation to enable out-of-sample prediction for biomolecular applications.

3 investors