Deep Tech Startups

Rondo manufactures thermal battery systems that store energy by heating refractory bricks with renewable electricity and release it as continuous industrial heat and power for manufacturing processes. The company serves cement, chemical, food and beverage, fuel, and textile producers seeking to decarbonize heat-intensive operations.

3 investors

Root Ventures is a San Francisco-based seed-stage venture fund that leads initial funding rounds for deep tech founders, with typical first checks of $3–5M. Run by engineers, it invests in companies across hardware, robotics, developer tools, AI/ML, and industrial technology.

3 investors

RUNWITHIT Synthetics builds synthetic environments and populations that model complex urban, infrastructure, and policy systems, using data science, simulation, and 3D visualization to support decision-makers in technology, policy, and infrastructure choices. It combines synthetic population modeling, GIS, and game-engine visualization for planning and resilience applications.

3 investors

Safe Intelligence provides a software platform, tooling, and services that use formal verification, testing, and robust learning to validate and harden machine learning models such as neural networks and tree ensembles. Its offering targets ML/MLOps teams seeking more reliable, robust models, with deployment locally or via private/single-tenant cloud and API-based pipeline integration.

3 investors

Sage Geosystems develops pressure geothermal technology to generate energy from the earth's subsurface heat, drawing on decades of experience drilling wells worldwide. The company operates in the geothermal energy sector, aiming to provide sustainable power generation.

3 investors

Sagence AI develops semiconductor technology based on analog in-memory compute methods to enable efficient AI computing for edge and data center applications. The company targets developers and customers building practical AI systems across various industries.

3 investors

Salad operates a peer-to-peer cloud computing network where users share spare computing resources for rewards while businesses run workloads like AI and gaming applications on the affordable, distributed infrastructure. The company uses a proprietary trust system to manage node performance and optimize hardware allocation across its community-powered cloud platform.

3 investors

Salt OS builds a platform for deploying and managing AI solutions on-premises for regulated enterprises, emphasizing data sovereignty and maintainability of AI workflows.

3 investors

SamanTree develops the Histolog Scanner, a real-time tissue imaging system that scans specimen surfaces at high resolution without slicing or slides, and supports remote physician collaboration. It targets surgeons and pathologists, offering intraoperative tissue assessment as an alternative to frozen section analysis.

3 investors

Scenic Biotech develops disease-modifying therapies for patients with neurological and metabolic genetic disorders using its Cell-Seq discovery platform to identify modifier genes. The company pursues "modifier therapy," which targets other genome functions that can neutralize disease impact rather than the primary disease-causing mutation.

3 investors

Scentian Bio combines synthetic biology and AI to develop biosensors based on synthesized insect odorant receptors, creating a digital sense of smell and taste that can detect and measure the concentration of thousands of compounds. Spun out of Plant & Food Research, the company holds patents around its odorant-receptor biosensing technology.

3 investors

SciRhom is a biotech company developing first-in-class humanized antibodies against iRhom2, which regulates the enzyme TACE/ADAM17 to block pro-inflammatory signaling pathways. Its pipeline targets autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, and lupus nephritis.

3 investors

Scrona develops InkLogic, a MEMS-based digital electrohydrodynamic (EHD) printhead that combines high-resolution electrostatic printing with a scalable multi-nozzle chip for industrial microfabrication. It targets advanced manufacturing and semiconductor packaging applications requiring ultra-high resolution and high-viscosity material processing.

3 investors

Secondmind builds cloud-native software using its Active Learning machine learning technology to help automotive engineers design and optimize complex vehicle systems with less data, fewer simulations, and fewer prototypes. It targets automotive engineering teams, aiming to reduce development time and support lower-emission vehicle development.

3 investors

S32 is a venture capital firm that makes concentrated, high-conviction investments in a small number of companies, focusing on areas such as artificial intelligence, computational biology, physical AI, infrastructure, cybersecurity, and enterprise. It also provides hands-on hiring support across engineering, AI, and go-to-market functions.

3 investors

Seer develops proteomics tools for large-scale protein analysis, including an assay, automation instrument, and analysis software for studying the proteome across human and non-human samples. Its products serve researchers running deep, reproducible proteomic studies at scale.

3 investors

Sensity AI develops deepfake detection technology that identifies synthetically generated or manipulated images, videos, and audio by using deep learning to detect pixel-level and acoustic artifacts left by generative AI. Its forensically robust analysis is aimed at states, organizations, businesses, individuals, and law enforcement handling cases of fraud, harassment, and abuse.

3 investors

SepPure Technologies develops nano-filtration membrane technology that replaces conventional energy-intensive chemical separation processes, reducing solvent use, energy consumption, and emissions. It serves industrial chemical manufacturers seeking cleaner separation methods.

3 investors

Sequence Bio discovers genetic causes of disease within Newfoundland and Labrador's founder population to develop breakthrough treatments, diagnostics, and preventions. The company focuses on translational biology and genetics research for patients globally.

3 investors

Seurat Technologies is a metal contract manufacturer that produces high-volume, industrial-scale metal parts using its proprietary Area Printing additive manufacturing technology, which decouples print speed from resolution. It serves conventional manufacturing markets and positions itself around decarbonization, with U.S. production based in a Boston facility.

3 investors

ShapeTX develops programmable RNA medicines by combining artificial intelligence with RNA technology to address genetic causes of disease.

3 investors

ShineFusion develops fusion energy technology, pursuing a step-by-step commercialization approach that generates revenue from intermediate applications to fund progress toward clean fusion power.

3 investors

Silicon Box develops semiconductor integration technology and chiplet solutions for manufacturers and semiconductor companies. The company focuses on overcoming supply chain bottlenecks in chip manufacturing and production.

3 investors

Silvec develops RNA-based therapies to protect trees, vines, and bushes from viral, bacterial, and fungal diseases without modifying the host genome. Its treatments use a proprietary type of RNA and are aimed at agricultural and horticultural crops such as citrus, olive, cacao, and banana trees.

3 investors