Deep Tech Startups

EtherealX (referred to as "The Guild") is developing Razor Crest Mk 1, a fully reusable medium-lift orbital launch vehicle designed to lower launch costs and support multi-customer, multi-payload missions with up to 16 orbit insertions per flight. The company operates what it describes as India's largest privately-owned rocket testing facility.

4 investors

Ethereal Machines provides precision CNC manufacturing services, machining aerospace-grade parts on in-house 3- and 5-axis platforms with full traceability and quality certifications (AS9100D, ISO 9001, ISO/IEC 27001). It serves customers needing high-precision components for demanding applications such as aerospace and space, designing and building its own machines, with an India-based and global focus.

4 investors

Evox Therapeutics develops exosome-based gene editing therapies using its ExoEdit platform, which combines exosome delivery with a proprietary CRISPR-based editor to treat severe neurodegenerative and other genetically-driven diseases. The therapies target the central nervous system to address the root cause of neurodegeneration.

4 investors

Exergy3 manufactures thermal energy storage systems that charge during low-cost electricity periods and deliver industrial heat, enabling decarbonization and cost reduction for manufacturing facilities. The technology operates at up to 1200°C with minimal heat loss and can co-fire with traditional fuel sources to reduce CO₂ emissions.

4 investors

Exo Therapeutics is a small molecule drug discovery company developing therapeutics through its ExoSight platform, which targets exosites—unique binding pockets on enzymes—to address previously undruggable diseases in oncology, inflammation, and other therapeutic areas.

4 investors

exo connects Macs and workstations into a single local inference cluster, automatically discovering devices, mapping network topology, and splitting AI models across device memory to run frontier models on-premises. It exposes standard OpenAI, Claude, Responses, and Ollama-compatible APIs for developers running AI locally without cloud infrastructure.

4 investors

Exotrail develops in-space mobility systems and services for satellite operators, including propulsion and orbital transfer to reposition satellites, avoid collisions, and deorbit at end of life. It also works on sustainable space operations such as in-orbit inspection, satellite refueling, debris removal, and Rendezvous, Proximity Operations and Docking (RPOD).

4 investors

ExpressionEdits builds a computational platform, the Genetic Syntax Engine, that uses AI and intron-based transgene design to improve protein expression for therapeutic applications. The company develops an internal pipeline of therapeutic proteins and works on gene therapy partnerships.

4 investors

Extellis is developing satellite technology to deliver high-resolution (1 m) Earth imagery at industrial scale for remote monitoring applications. It offers spaceborne insights to customers through an early adopters program ahead of its pathfinder launch.

4 investors

Exyn develops autonomous aerial robot systems designed to operate in GPS-denied environments, serving industries including mining, defense, and infrastructure inspection. The company offers full-stack robotic solutions that enable flexible multi-robot deployments with real-time environmental adaptation.

4 investors

Fuse Energy develops fusion energy technology, with work spanning hardened electronics and radiation testing (HEART) and recycling of radioactive waste, aiming to provide an on-demand clean energy source. It brings together a team across engineering, fusion science, energy policy, and manufacturing.

4 investors

Familiar builds an AI video-translation and dubbing model that combines voice cloning and full-face lip-sync in a single system, preserving tone, expressions, and background audio, with support for real-time streams. It offers an API, an MCP server for agents, and a self-serve dashboard for creators and platforms translating video into multiple languages.

4 investors

fibionic develops bionically optimized lightweight components using a patented process that places reinforcement fibers precisely where structural loads require them, reducing weight while increasing strength and sustainability. It offers a full-service package from FE-based topology optimization and rapid prototyping to large-series production, serving manufacturers of parts such as rotor blades, surfboard fins, and running shoes.

4 investors

Fifty Years is an investment firm founded and backed by 46 founders of tech companies valued between $1 billion and $100 billion, focused on supporting early-stage founders. The firm combines investor capital with hands-on operational expertise from experienced entrepreneurs to help the next generation build world-changing companies.

4 investors

1STBIO (퍼스트바이오) is a biotechnology company developing drug programs, including the HPK1 inhibitor immuno-oncology candidate FB849 and the NLY02 program. It focuses on advancing therapeutic pipelines to bring treatments to patients.

4 investors

Flightpath Biosciences develops microbiome-sparing, pathogen-specific drug candidates to treat infection-associated diseases by selectively targeting harmful bacteria while preserving healthy microbial communities. The company focuses on small molecule therapeutics for chronic and complex diseases, particularly those linked to pathogenic bacteria such as Crohn's disease.

4 investors

Floating Point builds high-fidelity datasets, evaluations, and benchmarks for visual AI systems, serving ML teams, startups, and model labs. The company offers both off-the-shelf data products and custom supervised dataset services to advance computer vision capabilities.

4 investors

FloodMapp develops operational flood forecasting and real-time inundation mapping technology using machine learning to provide early warning and situational awareness for communities and infrastructure. The company serves government agencies, emergency management organizations, and other clients seeking to reduce flood risk and protect lives globally.

4 investors

FluoRok, a spin-out of the University of Oxford, develops patented fluorinating technologies to produce fluorochemicals such as Li-ion battery electrolytes, agrochemicals, and pharmaceutical ingredients without generating toxic hydrofluoric acid. The company aims to offer safer, cheaper, and more sustainable chemical production methods.

4 investors

Focused Energy develops laser-driven fusion technology to commercialize fusion power generation at scale. The company applies proven physics and engineering to build fusion power plants for clean energy production.

4 investors

Folio Photonics develops optical storage media using multi-layer read/write materials science to provide enterprise-scale, immutable active archive storage. It targets organizations managing large-scale, long-term data archiving needs, positioning its technology on cost, security, and sustainability.

4 investors

Fortastra builds low-cost, maneuverable spacecraft designed to defend infrastructure in orbit, combining commercial components with custom engineering. Its systems use open-architecture software to autonomously sense, maneuver, coordinate, and respond to orbital threats when human operators cannot stay in the loop.

4 investors

Fortius Metals develops advanced materials for welding and manufacturing applications.

4 investors

Frenetic develops software for designing and optimizing magnetic components used in power electronics, using an AI-based modeling approach to replace traditional engineering methods. It serves companies working on power electronics and the electrification transition, with distribution through a global network.

4 investors