Deep Tech Startups

Texas Mineral Resources is a US-focused mining company developing its Round Top deposit to produce and refine heavy rare earth elements. It aims to supply these strategically important minerals for domestic defense and technology infrastructure.

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Tinos Tx develops first-in-class small molecule inhibitors targeting the RNA demethylase FTO to destabilize tumor-driving RNA and kill cancer cells. The company builds on research into how RNA methylation controls cellular survival to create cancer therapeutics.

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Titomic provides advanced metal manufacturing as a service using proprietary cold spray technology (Titomic Kinetic Fusion™) for on-demand production, repair, and materials engineering. The company serves defense, aerospace, oil & gas, mining, and industrial manufacturing sectors with field-based or in-facility deployments, design consulting, and custom materials solutions.

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Tnemec develops specialized coatings and linings designed to protect structures from corrosion, UV degradation, and abrasion across various industries. The company emphasizes rigorous performance testing and high-quality formulations to deliver long-lasting asset protection solutions.

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TNF Pharmaceuticals is a clinical-stage biopharma company developing therapies for autoimmune and inflammatory diseases, with lead candidates including MYMD-1, an oral TNF-alpha inhibitor, and Supera-CBD, a synthetic cannabidiol analog.

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Tomorrow Holding LLC develops and commercializes a patented "Fiber Reactor" liquid-liquid extraction and separation process that runs continuous reaction chemistry to cut energy use and improve yield and purity. Through subsidiaries it applies the technology to industrial processes such as vegetable oil purification (corn oil, cottonseed oil, palm oil), biodiesel conversion, nanoparticle creation, and chiral reactions.

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Topaz Bio develops therapeutics for skin diseases by engineering the skin microbiome using metagenomics and synthetic biology. The company targets the substantial patient population affected by skin conditions.

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Torch Technologies is an employee-owned company providing research, development, and engineering services to the U.S. Federal Government and Department of Defense. Its work spans software development, test and evaluation, lifecycle sustainment, systems engineering, and advanced sensor technologies for defense applications.

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TransCode Therapeutics is an RNA-focused drug developer building oncology therapeutic candidates and diagnostics, using its TTX delivery technology across immunotherapy, gene editing, radiotherapy, and cancer vaccines. Its pipeline targets cancers such as pancreatic cancer through RNAi, RIG-I agonism, CRISPR, radioisotope delivery, and mRNA-based vaccines.

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TreadStone Technologies manufactures specialized coatings for electrochemical systems used in energy applications. The company supplies global markets with patented coating technologies developed through materials science research and commercialized in industrial facilities.

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Triad Growth Partners is a venture studio that identifies and spins out cleantech companies focused on water and environmental challenges, working with universities and industry partners. The firm uses research-backed processes to de-risk and commercialize environmental technologies into operating companies.

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Turn Therapeutics develops topical therapies for skin diseases using its proprietary PermaFusion drug delivery platform. The company's lead program, GX-03, is designed to treat moderate to severe eczema by reducing IL-36 signaling and downstream inflammatory cytokines.

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Tusaar recovers rare earth elements from mine tailings and industrial waste using a proprietary media and chemical process, aiming to build a domestic U.S. supply chain for critical materials used in electric vehicles, wind turbines, defense, and electronics. The company operates a large-scale pilot facility in Broomfield, Colorado, and targets being the first U.S. company to extract rare earths at scale from non-traditional sources.

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U.S. Gold Corp. is a mineral exploration and development company advancing gold and other precious metal projects in Wyoming, Nevada, and Idaho. The publicly traded company (NASDAQ: USAU) focuses on exploration using geological expertise and technology.

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Ubiety builds AI-powered "presence intelligence" technology that passively detects and analyzes wireless RF signals to identify presence, behavioral patterns, and coordinated activity. Its platform, SignalWise, provides situational awareness for public safety, critical infrastructure, and national security organizations, integrating with existing security and surveillance systems.

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UC3 (UltraConductive Copper Company Inc.) is an energy-tech engineering startup developing copper/graphene composite meta-materials that increase copper's conductivity by embedding nano-layers of graphene, for use in ultra-conductive wires and foils. Its target applications include electric power grids, electric vehicles, electronics, and data networks.

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United Spaceports operates commercial spaceport facilities offering tourist experiences including zero gravity flights, fighter jet rides to the edge of space, and spacewalk experiences. The company has FAA and county runway approval with assets appraised at $84 million.

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URZ3 Energy is a uranium exploration company identifying strategic assets to meet rising demand for nuclear energy. The company serves the clean energy sector, particularly supporting sustainable AI data centers and North American energy independence.

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Vala Sciences develops high-content kinetic screening technologies, including imaging instruments, analysis software, and AI tools, to extract single-cell insights for drug discovery, disease modeling, and therapeutic research. It also provides contract research services such as cardiac safety screening, neuroscience applications, and high-content analysis for preclinical researchers.

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Valaurum manufactures the Aurum, a small verifiable unit of physical gold made from micro-layers of gold sealed between polymer, marketed as an investment product, collectible, and legal tender currency. It serves precious metals investors and mints through channels including national mint distributors and retail stores across North America, Europe, and Asia.

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Valliscor is a technology-driven chemical manufacturer specializing in high-value fluorine-containing compounds for the pharmaceutical, semiconductor, and polymer industries. The company produces pharmaceutical starting materials, semiconductor etchants, and specialty monomers leveraging proprietary and licensed technologies.

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Vaztec develops advanced internal combustion engine technologies, including rotary valve cylinder heads that replace conventional poppet valve systems, and licenses these technologies to product manufacturers. Its core offering aims to improve engine efficiency, power density, and lifespan while reducing vibration and noise across a range of engine applications.

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Ventiva develops ionic (electrohydrodynamic) thermal management modules that provide targeted, fanless cooling for electronic systems such as ultra-thin laptops, edge AI devices, and datacenter components. The technology has no moving parts and frees up board space for additional memory, storage, or battery, serving hardware and system designers building compact, high-performance AI systems.

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Verasonics builds research ultrasound platforms (including the Vantage NXT and Vantage Research systems) that let users acquire, store, process, and analyze ultrasound data with programmable SDKs and real-time raw channel data access. It serves researchers and product developers across fields such as biomedical, material sciences, earth sciences, and biometrics, and its systems are for laboratory research/development rather than approved clinical use.

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