Deep Tech Startups

Lightpath Technologies manufactures and sells optical components, assemblies, and modules for infrared and visible light applications, serving defense, industrial, and security customers globally. The company also provides engineering services and custom optical solutions to government and commercial clients.

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Lightwave Logic develops proprietary electro-optic polymers and modulator materials designed to increase data transmission speeds and reduce power consumption in AI and data center infrastructure. The company targets next-generation internet infrastructure serving data center operators deploying generative AI applications.

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LiNova Energy develops polymer cathode battery technology designed for safety, supply chain resilience, and reduced dependence on critical minerals. The company serves battery manufacturers and the broader energy storage market through materials innovation that works across multiple battery chemistries.

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Lisi Global develops Directed Energy Systems (DES), a precision electrification platform that applies controlled pulses of electrical energy to target weeds, pests, and nuisance organisms. The technology serves agriculture, infrastructure, and land management applications such as rail corridors, specialty crops, turf, and soil systems.

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Lodestone Biomedical develops biosensing and monitoring tools for the tumor microenvironment in preclinical cancer research models, enabling detection of immune response during early-stage drug discovery. Its research-use-only products and services serve drug development researchers conducting preclinical studies.

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Lotus Leaf Coatings manufactures and distributes superhydrophobic and superhydrophilic coating products for industrial applications. The company seeks licensing and supply partnerships with global businesses in industries requiring water-resistance or water-absorption performance improvements.

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Lucendi develops AI-enabled smart measurement platforms using computational microscopy and holographic imaging for micro-object detection and characterization across various industrial and scientific applications.

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MadHat Media develops and holds a portfolio of communications and networking technologies focused on next-generation network infrastructure and protocol innovation. Through its subsidiary MadHat TV, it also operates live and on-demand content delivery and distributed streaming systems.

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MagiQ Technologies develops sensing, communications, and security systems—rooted in quantum science, high-speed electronics, and digital signal processing—for defense agencies, energy companies, wireless carriers, and critical infrastructure operators. Founded in 1999 and based in the Greater Boston area, the company works with U.S. government bodies such as the Air Force, Navy, Army, DARPA, DOE, and NASA on demanding technical missions.

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Magstim develops neurotechnology and neurostimulation devices for healthcare providers and researchers, focusing on neuromodulation and neurophysiology applications. The company manufactures and supports innovative medical devices used in patient care and neuroscience research globally.

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Malcova develops medical imaging technology, including a Narrow-Beam CT system, aimed at early detection of diseases such as breast cancer and stroke with lower radiation and reduced patient discomfort. Its tools are intended for radiologists and healthcare providers to support more accurate diagnosis.

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Martin/Martin is an employee-owned structural and civil engineering firm that provides design and construction administration services for developers, architects, public agencies, contractors, and institutions. It works on projects such as hospitals, convention centers, data centers, advanced manufacturing facilities, and sports venues across the United States.

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Masten develops reusable vertical takeoff and vertical landing (VTVL) rocket vehicles that fly payloads on suborbital trajectories to test entry, descent, and landing systems for technology developers. Its vehicles support precision landing and hazard avoidance testing aimed at enabling landings on the Moon and Mars.

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Matinas BioPharma develops a Lipid Nano-Crystal (LNC) drug delivery platform that enables oral, intracellular delivery of small molecules and oligonucleotides. Its lead product MAT2203 is an amphotericin B formulation, alongside discovery programs in oncology and inflammation.

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Maykr is a holding company and investment platform that acquires and partners with operating companies at the intersection of AI, infrastructure, and industrial technology. It builds enterprise value through capital, operational support, and strategic expansion, with operating companies and a portfolio spanning AI, energy, healthcare, and applied intelligence.

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Atomera develops Mears Silicon Technology (MST), a patented quantum-engineered material that enhances transistors by adding partial monolayers of oxygen to silicon for faster, more controlled electron movement and better dopant diffusion control. The company licenses this technology and provides integration engineering support to semiconductor manufacturers for applications including mobile phones, 5G, IoT devices, DRAM, and image sensors.

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Melior Innovations develops materials technologies designed to address market needs across various industries. The company focuses on creating disruptive solutions through a culture emphasizing innovation and market application.

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MicroVision develops lidar and perception systems for automotive OEMs, supporting autonomous driving and advanced driver-assistance systems. The company focuses on scaling these hardware technologies from R&D to commercial products for the mobility sector.

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MIIR Audio Tech develops audio technology, with a team combining engineering and neuroscience/science advisory expertise. The company's product involves proprietary inventions in the audio space.

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MIVI develops medical devices to improve outcomes in neurointerventional procedures, specifically targeting aspiration in distal stroke occlusions and reducing distal embolization during mechanical thrombectomy.

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Mixed-Signal Devices builds an all-digital, CMOS-based precision timing platform, including oscillators and clock-generation technology, that replaces legacy analog clock chains with multi-gigahertz timing and sub-20 femtosecond jitter. Its clocks target AI infrastructure and GPU fabrics, 5G base stations, and automotive systems such as radar and ADAS.

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Molecular Vista builds nano-IR microscopes (the Vista series/VistaScope) using photo-induced force microscopy (PiFM) and photo-induced force IR spectroscopy (PiF-IR) for nanoscale chemical analysis. It sells these instruments and offers contract analysis services to researchers working in materials science, chemistry, physics, and semiconductor analysis.

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MyFloraDNA is a biotechnology company providing genomic testing products, services, and education for the cannabis industry. It serves growers worldwide, aiming to help improve crop yields, quality, and sustainability through access to genomic sciences.

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Myosana Therapeutics develops non-viral, muscle-targeted gene therapies aimed at slowing skeletal muscle degeneration and heart failure in Duchenne muscular dystrophy (DMD) and other neuromuscular and cardiac diseases. The company works in the biotech and gene therapy field.

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