Deep Tech Startups

Alex Metals is a mineral exploration company focused on discovering and developing high-grade silver and gold deposits in Southeast Alaska's Alexander Terrane. The company controls three exploration projects targeting volcanogenic massive sulfide (VMS) mineralization, a deposit type with significant precious metal content.

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Algemetric is a deep-tech cryptography company that develops privacy-enhancing technologies such as secure multi-party computation (MPC) and homomorphic encryption (FHE) for privacy-preserving data collaboration and secure machine learning. Founded in 2016, it works to translate cryptography research into practical applications for handling sensitive data and privacy requirements.

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Alio Labs develops advanced plasma processing technology for photonics manufacturing, delivering high-performance optical coatings for industrial metrology and factory automation applications. The company specializes in proprietary Quadrode plasma processing for substrate coating with optimized optical performance.

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Alligant Scientific (Iontra) develops patented battery charging technology, using signal processing and a "Charge-Control" algorithm to prevent cell damage, enabling rechargeable batteries to charge faster and last longer. It works with manufacturers to engineer custom charging recipes tuned to their product performance goals.

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AltaRock Energy (ARE) develops drilling technology for super-hot rock (SHR) geothermal energy, aiming to make geothermal power viable in more locations. The company works with developers of non-mechanical drilling methods, such as plasma and millimeter wave techniques, to reach depths of up to 15-20 km.

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Alzheon is a clinical-stage biopharmaceutical company developing oral small-molecule drugs for Alzheimer's disease and other neurodegenerative disorders, with a Phase 3 program for its lead compound valiltramiprosate (ALZ-801). It operates an anti-aggregation platform including two clinical-stage oral programs and a small-molecule discovery library.

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AmberGen operates the MaxOmic Laboratory, offering multiomic spatial biology imaging and analysis services along with probes, panels, and antibody conjugation kits based on its patented photocleavable mass-tag technology. It serves researchers, drug developers, and clinicians in the life sciences and biotech sector.

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Ambient Biosciences is a biotechnology company specializing in biostabilization technology. The company serves the broader life sciences and healthcare sectors with solutions to preserve biological materials and improve health outcomes globally.

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American Semiconductor develops and manufactures ultra-thin chip technology, including its Semiconductor-on-Polymer (SoP) wafer level chip scale packaging for thin-device applications such as chip-on-flex and multi-chip packaging. It provides design, assembly, test, and custom engineering services for the semiconductor industry from its facility in Boise, Idaho.

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AmideBio discovers and designs peptide therapeutics for metabolic diseases, using in-silico design and its BioPure process to produce ultrapure peptides. It also sells manufactured peptides and offers custom synthesis services to the biopharmaceutical industry and research community, aiming to license drug candidates at or before the IND stage.

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AmPd Labs provides additive manufacturing (3D printing) consulting and production services for industrial clients, helping them reduce waste, lower costs, and accelerate production timelines. The company leverages over 15 years of digital manufacturing expertise in complex design and production challenges, serving as a regional hub for advanced manufacturing education and capability.

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AMPeers develops high-temperature superconductor (HTS) wire using proprietary Advanced MOCVD manufacturing technology that delivers superior performance for next-generation power applications. The company serves industries requiring compact, efficient power systems by scaling breakthrough superconducting wire technology from research to commercial production.

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Amphix Bio develops peptide therapeutics based on a supramolecular chemistry platform that forms nanostructure scaffolds to activate regenerative signaling in cells and tissues. Its pipeline targets neurological injuries, neuro-inflammatory diseases, and musculoskeletal disorders.

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AmpliTech designs and builds 5G ORAN radio equipment ranging from 4T4R to 64T64R RAN-ORAN solutions, including CU/DU and maintenance services, using in-house 5G MMIC chips and Front End Modules for extended-range coverage. It also develops satellite receiver and ground station system components for telecom and satellite networks.

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ANDE develops Rapid DNA technology, providing mobile and ruggedized systems that let field teams perform DNA analysis on-site. The equipment is designed for rapid integration of DNA testing into operational workflows outside of traditional laboratory settings.

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Anivive develops new medicines for companion animals, using software across the drug development process to accelerate the creation of treatments. It serves the animal health community, focusing on veterinary and pet health pharmaceuticals.

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Apertor develops a class of therapeutics called Interceptors that selectively disrupt disease-causing protein-protein interactions through proximity induction, recruiting an abundant protein found in cancer cells to block the interactions. The company uses a synthetic biology platform to build a pipeline of cancer treatments.

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Applied Biological Laboratories develops antiviral biotechnology treatments targeting respiratory viruses using a patented biologic platform that combines host-directed immune modulation and microbe-directed mechanisms. The company conducts research using human respiratory organoids to identify and develop antiviral and anti-inflammatory therapeutic solutions.

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Applied Digital builds and operates large-scale data centers purpose-built for AI, machine learning, and high-performance computing workloads. The company designs campuses with high-density, low-latency infrastructure to support next-generation artificial intelligence applications.

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Applied Spectra, Inc. (ASI) makes analytical instruments based on laser ablation (LA) technology, including LA-ICP-MS and LIBS systems, for elemental chemical analysis. Its instruments serve environmental analysis, alternative energy manufacturing, forensic science, and analytical research customers.

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Arc Suppression Technologies develops electronic power contact arc suppression technology and publishes technical research on contact arcing, arc-flash events, and the electrical end-of-life of power relays and contactors. The company serves the electromechanical and electronic power switching industry with products and concepts such as the Contact Arc Suppression Factor (CASF) and EPCAS.

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Arcadian Infra develops long-haul fiber optic routes in the Western United States, with 3,500 route miles planned to bring high-speed broadband connectivity to rural and historically bypassed communities. The company builds digital infrastructure connecting cities across states including California, Nevada, Arizona, Utah, Colorado, and Texas.

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Argo Graphene develops and commercializes graphene-based technologies for industrial applications, including modified concrete and asphalt for construction and infrastructure. The company operates globally from its Vancouver headquarters with subsidiaries and R&D partnerships, focusing on sustainable, high-performance alternatives to conventional materials.

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Ascenium develops computing technology focused on improving compute efficiency and reducing energy consumption in data centers. The company is backed by Norwegian investors with expertise in technology disruption.

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