Deep Tech Startups

AltaRock Energy (ARE) develops drilling technology for super-hot rock (SHR) geothermal energy, aiming to make geothermal power viable in more locations. The company works with developers of non-mechanical drilling methods, such as plasma and millimeter wave techniques, to reach depths of up to 15-20 km.

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Alzheon is a clinical-stage biopharmaceutical company developing oral small-molecule drugs for Alzheimer's disease and other neurodegenerative disorders, with a Phase 3 program for its lead compound valiltramiprosate (ALZ-801). It operates an anti-aggregation platform including two clinical-stage oral programs and a small-molecule discovery library.

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Ambient Biosciences is a biotechnology company specializing in biostabilization technology. The company serves the broader life sciences and healthcare sectors with solutions to preserve biological materials and improve health outcomes globally.

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American Semiconductor develops and manufactures ultra-thin chip technology, including its Semiconductor-on-Polymer (SoP) wafer level chip scale packaging for thin-device applications such as chip-on-flex and multi-chip packaging. It provides design, assembly, test, and custom engineering services for the semiconductor industry from its facility in Boise, Idaho.

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AmideBio uses in-silico design and proprietary peptide synthesis to develop preclinical peptide drug candidates for metabolic disease. It also offers custom peptide synthesis services and a catalog of high-purity peptides for customers.

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AmPd Labs provides additive manufacturing (3D printing) consulting and production services for industrial clients, helping them reduce waste, lower costs, and accelerate production timelines. The company leverages over 15 years of digital manufacturing expertise in complex design and production challenges, serving as a regional hub for advanced manufacturing education and capability.

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AMPeers develops high-temperature superconductor (HTS) wire using proprietary Advanced MOCVD manufacturing technology that delivers superior performance for next-generation power applications. The company serves industries requiring compact, efficient power systems by scaling breakthrough superconducting wire technology from research to commercial production.

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Amphix Bio develops peptide therapeutics based on a supramolecular chemistry platform that forms nanostructure scaffolds to activate regenerative signaling in cells and tissues. Its pipeline targets neurological injuries, neuro-inflammatory diseases, and musculoskeletal disorders.

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ANDE develops Rapid DNA technology, providing mobile and ruggedized systems that let field teams perform DNA analysis on-site. The equipment is designed for rapid integration of DNA testing into operational workflows outside of traditional laboratory settings.

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Andon Bio is a spinout from the University of Colorado School of Medicine developing aa-tRNA-seq, a molecular biology method for studying protein translation and tRNA aminoacylation. The company builds experimental and computational tools for research into cellular translation mechanisms.

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Anivive develops new medicines for companion animals, using software across the drug development process to accelerate the creation of treatments. It serves the animal health community, focusing on veterinary and pet health pharmaceuticals.

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Applied Biological Laboratories develops antiviral biotechnology treatments targeting respiratory viruses using a patented biologic platform that combines host-directed immune modulation and microbe-directed mechanisms. The company conducts research using human respiratory organoids to identify and develop antiviral and anti-inflammatory therapeutic solutions.

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Applied Digital builds and operates large-scale data centers purpose-built for AI, machine learning, and high-performance computing workloads. The company designs campuses with high-density, low-latency infrastructure to support next-generation artificial intelligence applications.

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Applied Spectra, Inc. (ASI) makes analytical instruments based on laser ablation (LA) technology, including LA-ICP-MS and LIBS systems, for elemental chemical analysis. Its instruments serve environmental analysis, alternative energy manufacturing, forensic science, and analytical research customers.

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Arc Suppression Technologies develops electronic power contact arc suppression technology and publishes technical research on contact arcing, arc-flash events, and the electrical end-of-life of power relays and contactors. The company serves the electromechanical and electronic power switching industry with products and concepts such as the Contact Arc Suppression Factor (CASF) and EPCAS.

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Arcadian Infra develops long-haul fiber optic routes in the Western United States, with 3,500 route miles planned to bring high-speed broadband connectivity to rural and historically bypassed communities. The company builds digital infrastructure connecting cities across states including California, Nevada, Arizona, Utah, Colorado, and Texas.

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Argo Graphene develops and commercializes graphene-based technologies for industrial applications, including modified concrete and asphalt for construction and infrastructure. The company operates globally from its Vancouver headquarters with subsidiaries and R&D partnerships, focusing on sustainable, high-performance alternatives to conventional materials.

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Ascenium develops computing technology focused on improving compute efficiency and reducing energy consumption in data centers. The company is backed by Norwegian investors with expertise in technology disruption.

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ASP (ASP Isotopes) is an advanced materials company developing proprietary technology and processes to produce and enrich isotopes for markets including nuclear medicine and therapeutics, green energy generation, and quantum computing. Its initial focus is constructing plants in South Africa to produce highly enriched isotopes for the nuclear medicine market.

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Astound Research monitors federal and non-federal research funding sources and helps academic and lab researchers find, apply for, and secure grants by identifying relevant opportunities, creating required content, and connecting collaborators. It serves scientists and research labs seeking external funding.

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Astrotech develops mass spectrometry and molecular analysis instruments derived from space-grade engineering, used for detecting trace explosives, confirming synthetic opioids at borders, and monitoring VOCs in the field. Its products target security, border control, and field-testing applications requiring rugged, reliable detection tools.

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AtoMe develops high-performance metal powders that reinforce existing alloys with ceramic nanomaterials to create metals with greater durability and higher operating limits. Based on research from MIT, its powders integrate into existing powder metallurgy processes and can be tailored for custom manufacturing plans.

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Atsign provides technology for privacy and security, device administration, and connectivity, working with system integrators, IT solutions providers, security consultants, platform providers, and device makers. Its offering targets deployment of secure, private connected systems and IoT devices.

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Augmntr is a systems engineering and software development firm that builds real-time intelligence systems combining edge AI, multi-modal sensing, and spatial computing for use in low-bandwidth, time-critical environments. It serves defense and commercial sectors, connecting sensors to field-ready platforms that support real-time decision-making.

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