Deep Tech Startups

Optical Waters manufactures UV-C optical fibers that emit germicidal light along their entire length for disinfection applications. The fibers are flexible and customizable, designed to be integrated into various surfaces and equipment to deliver ultraviolet sterilization where contamination is a concern.

1 investor

Hamamatsu Photonics makes the L10711-26 open-type microfocus X-ray source, offering a minimum resolution of 0.2 μm, selectable W or LaB₆ cathodes, a 20–160 kV tube voltage range, and four focus modes. The product targets non-destructive testing (NDT) and industrial CT imaging workflows.

1 investor

Optics11 develops fiber-optic sensing systems designed for harsh operating environments, providing ultra-sensitive, low-power monitoring of temperature, pressure, strain, and vibration. Its solutions serve defense, energy infrastructure, and industrial operators for asset monitoring and security.

1 investor

OptimalPSI develops patient-specific spinal fusion implants (TLIF) designed with an optimization algorithm that accounts for each patient's bone structure and load distribution to reduce subsidence risk. An ETH Zürich spin-off, it serves spine surgeons treating lumbar fusion patients at risk of post-operative subsidence.

1 investor

Optios develops an AI platform that collects neurophysiological data in real-time to understand brain activity and performance, then delivers actionable insights and interventions to optimize human performance across training, coaching, and human-AI team scenarios. The platform processes 22 million neurophysiological data points per hour via sensors to generate task-relevant neuro-cognitive metrics and adaptive recommendations.

1 investor

Optiple develops optical products and lens technologies, including eyewear, bike visors, and AR optics. The company holds patents related to curved lens bonding technology (GHLC).

1 investor

OptiSeis Solutions provides seismic exploration and subsurface imaging services with an emphasis on high-resolution data processing and advanced reservoir characterization. The company serves oil and gas exploration clients seeking cost-effective, environmentally mindful geophysical solutions.

1 investor

Optixlog provides a self-hosted, AI-native context layer that captures raw engineering data generated across simulation, layout, fabrication, metrology, and characterization workflows. It is aimed at enterprise engineering teams that need to retain control over their infrastructure, access, and data handling.

1 investor

Metamaterials develops advanced materials and functional surfaces using nanofabrication technologies such as lithography, holography, and metamaterial coatings. Its products serve markets including brand protection, banknote and government ID security, aerospace and defense, automotive, consumer electronics, energy, and medical imaging.

1 investor

OQC designs and manufactures quantum computers engineered for commercial applications, beginning with systems optimized for financial services and security sectors. The company develops Application Optimised Compute systems through a multi-generation product roadmap targeting quantum advantage in finance, defence, life sciences, and cryptography.

1 investor

Ora develops loudspeaker membranes made from graphene (GrapheneQ) that reduce harmonic distortion, lower power consumption, and increase sound pressure levels. Its acoustic material targets audio hardware makers across applications including gaming headsets, smartphones, laptops, home audio, automotive, and hearing aids.

1 investor

Ora Graphene develops nano-materials based on graphene technology for high-performance audio applications. The company serves audio equipment manufacturers and beyond through commercialized graphene solutions.

1 investor

ORamaVR develops a platform for high-fidelity medical simulation training using extended reality technology, serving device companies, simulation centers, and hospitals globally. The company addresses the challenge of scaling medical education through spatial computing and computer graphics innovations.

1 investor

Orange Grove Bio is a biotech venture firm that builds and backs cell therapy and immuno-oncology companies, forming subsidiary companies (subcos) such as Ipinovyx and DomainOne Therapeutics. It operates in the biopharmaceutical and life sciences investment space.

1 investor

OraVentis develops a real-time decision-support system using an industrial-grade LiDAR to detect and control fugitive dust and particulate atmospheric emissions in industrial operations. The solution maps dust concentrations across hundreds of meters and generates contextual alerts to guide operators in addressing emission sources at their origin.

1 investor

Orbion provides a computational platform for protein engineering that characterizes sequences, ranks stabilizing mutations, predicts construct expression, and generates experimental protocols to filter designs before lab synthesis. The platform serves biotechnology researchers and protein engineers working to optimize protein candidates for expression and function.

1 investor

Orbis Medicines is a drug discovery company developing orally bioavailable macrocycle drug candidates as alternatives to injectable biologics, targeting both intracellular and extracellular protein targets. It uses a proprietary chemistry and machine-learning platform to systematically explore macrocycle chemical space and generate optimized drug candidates.

1 investor

Orbit works on complex problems in neuroscience.

1 investor

Orbital builds commercial AI compute infrastructure in Low Earth Orbit, deploying satellite-hosted GPU payloads with high-bandwidth ground links for AI inference. The company positions space-based data centers as a way to bypass terrestrial power grid constraints.

1 investor

Orbital Industries is an "AI Industrial" company that develops physical AI models—including AI-accelerated simulators and autoresearch agents for advanced materials—to speed up the design and manufacture of hardware products. Its first commercial products are new molecular classes for high-density GPU cooling in AI data centers, with plans to expand into energy, semiconductors, and other materials and machines.

1 investor

Orbital Matter designs and builds large rigid structures directly in orbit using its Printer Assisted Deployment System (PADS), which constructs continuous booms from 10m to 100m+ without hinges or folding mechanisms. The technology supports large-area space hardware such as solar arrays, radiators, and antennas for satellite constellations, space data centers, and multi-module space stations.

1 investor

Orbital Paradigm operates a logistics platform that connects shippers, carriers, and stakeholders to streamline global freight operations with real-time tracking and process automation. The platform serves businesses of all sizes seeking to simplify international shipping and logistics management.

1 investor

Orbital Micro Systems (now Weather Stream) develops and manufactures miniaturized millimeter-wave microwave radiometer instruments for ground, air, and space-based applications, including its GEMS family used for satellite meteorology and weather forecasting. It also supplies custom radiometer calibration hardware to partners such as Ball Aerospace and NASA JPL for defense and Earth-observation missions.

1 investor

Ore Energy develops long-duration iron-air battery technology for renewable energy storage using cost-effective, recyclable materials like iron, water, and air. The company targets the global sustainable energy transition market with energy storage solutions.

1 investor