Deep Tech Startups

ON.energy builds grid-safe, resilient energy infrastructure systems that integrate with existing power grids and support hospitals, data centers, and cities. The company focuses on making energy reliable, clean, abundant and affordable through AI-driven infrastructure solutions.

1 investor

Onava is a drug discovery company that combines AI-native protein engineering, autonomous orchestration of model training and experimental feedback, and high-throughput functional assays to develop next-generation therapeutics. Its platform uses a cross-program data flywheel where insights from each program inform future candidate optimization.

1 investor

OncoNano Medicine develops a proprietary nanotechnology platform for cancer therapeutics that targets the acidic tumor microenvironment to improve drug delivery to tumors. The company serves oncology patients and builds a pipeline of therapies designed for more precise cancer treatment.

1 investor

OncoSenX is a late-stage pre-clinical cancer therapeutics company developing treatments that target solid tumors based on transcriptional activity. Its system pairs a patented Proteo-Lipid Vehicle (PLV) delivery agent with plasmid DNA payloads that induce apoptosis in cancer cells while sparing adjacent cells.

1 investor

Oncoxome develops an oral delivery platform for cancer therapies that targets tumor cells directly with minimal off-target toxicity. The platform enables delivery of various therapeutic modalities including CRISPR, siRNA, mRNA, and proteins to cancer patients.

1 investor

One Robot builds simulation environments with world models that enable robotics teams to train manipulation policies faster by learning physics and visuals from real robot experience, reducing reliance on physical hardware during development.

1 investor

OneVisage develops biometric authentication technology and OEM solutions aimed at preventing digital identity theft and phishing attacks. Its solutions are sold to large IT integrators, hardware manufacturers, cybersecurity vendors, and Identity & Access Management providers.

1 investor

Onlife develops spatial behavioral intelligence technology that combines online and offline data to deliver personalized, location-aware experiences across consumer and enterprise applications. The company uses spatial AI and behavioral models to inform real-time decisions for individuals, businesses, and municipalities.

1 investor

Ontario Centres of Innovation (OCI) is an ecosystem connector that supports the commercialization of academic intellectual property and facilitates industry-academic collaborations to drive economic growth in Ontario. The organization invests in early-stage companies, supports SMEs in adopting emerging technologies, and develops talent across sectors including advanced manufacturing, clean technology, and automotive innovation.

1 investor

First Contact builds a high-fidelity tactile sensing glove with 847 pressure-sensing taxels per hand running at 240 Hz, including coverage on the sides and tips of the fingers. The device ships with a Python SDK and optional motion-capture support, targeting robotics and tactile data collection applications.

1 investor

Open Bionics develops 3D-printed bionic hands called the Hero Arm, designed to be affordable, functional, and aesthetically appealing alternatives to traditional prostheses. The company serves individuals with upper limb differences and limb loss, operating in the medical devices and assistive technology space.

1 investor

OpenProtein.AI offers protein language models and AI infrastructure for protein engineering, covering de novo sequence design, variant effect prediction, in silico screening, and training specialized models on proprietary data. Accessible via a no-code GUI and APIs, it serves biology and computational research teams working in protein design and drug discovery.

1 investor

Open Stent Solution develops a percutaneous medical device for mitral and tricuspid valve replacement in cardiac patients ineligible for open-heart surgery. The company leverages ribbon-based valve technology to enable less invasive treatment with smaller delivery systems adaptable to various valve sizes.

1 investor

Open Culture builds an automated laboratory platform (Habitat) that autonomously runs cell-culture experiments — perfusing, imaging, and recording living samples — and an AI agent that plans and executes experiments from plain-language descriptions while organizing results into a queryable knowledge graph. It serves neuroscience and biology research labs, drawing on the founders' prior Braingeneers work in electrophysiology and AI.

1 investor

OpenCV is a computer vision library that provides GPU-accelerated functionality for image processing and parallel computations. It enables developers to run vision algorithms on NVIDIA CUDA-enabled graphics processors while maintaining consistency with its CPU-based implementation.

1 investor

Openfabric AI is building a decentralized platform for AI services, aimed at connecting AI agents and letting network participants contribute computing power for AI execution and training. It focuses on decentralization, usability, security, an in-built exchange medium for AI services, interoperability, and scalability.

1 investor

Opera is an agentic security operations platform designed for cyber-physical environments, providing security capabilities for physical and digital security integration.

1 investor

OPIRIS develops multimodal optical imaging systems that sense across multiple spectral ranges (UV through LWIR) for applications including target detection in degraded visual environments, metrology for semiconductor and metasurface manufacturing, and non-invasive medical imaging for rheumatology and oncology.

1 investor

OPNT develops network-based timing solutions that provide GPS-independent synchronization for telecom and other critical infrastructure using fiber optic networks and White Rabbit protocol technology. The solutions offer sub-nanosecond accuracy across 4G/5G networks, power systems, financial markets, and positioning services.

1 investor

Opsydia develops optical and photonic technologies for precision manufacturing, emerging from research in adaptive optics and laser processing at the University of Oxford. The company applies advanced laser machining and optical fabrication techniques to enable high-resolution processing in transparent materials for industrial and scientific applications.

1 investor

Spring Silicon builds full-stack compute infrastructure, spanning compilers to ASICs, purpose-built for physical AI and edge inference to power autonomous machines. It targets industries such as manufacturing, defense, energy, and transportation that rely on robots, drones, and autonomous vehicles.

1 investor

Optect develops optical flame detection technology for long-range fire identification in wildfire-prone areas and asset protection. The company's IR3 detector uses infrared wavelength recognition to detect flames at distances exceeding 1000m and operates reliably in smoke-filled conditions.

1 investor

Optelos develops a visual inspection data management and AI analytics platform that helps companies transform asset inspection workflows through data management, analytics, and visualization. The platform serves organizations across multiple industries that need to manage and analyze inspection data at scale.

1 investor

Optic (referred to as Bioptic) applies AI and foundation models to biopharma research and drug discovery, combining machine learning with scientific domain expertise for R&D. The company targets the biopharma industry, aiming to distill scientific knowledge into scalable software for therapeutics development.

1 investor