Deep Tech Startups

GenKan is a manufacturing shop-floor monitoring system that uses installed sensors (including RFID) to automatically capture production data, making processing costs, material costs, and electricity consumption visible for high-mix, low-volume manufacturers. It also provides cost-management consulting support, from actual cost analysis to KPI setting, aimed at Japanese factory operators.

2 investors

LifeScapes develops brain-machine interface (BMI) technology combining neuroscience and AI to connect the brain with machines, aimed at rehabilitation for patients with severe paralysis after stroke. The company works to expand rehabilitation possibilities and support recovery for stroke patients.

2 investors

Luxonus develops photoacoustic (optical ultrasound) 3D imaging devices and services for visualizing blood and lymphatic vessels, building on technology from Japan's Cabinet Office ImPACT program. The company designs, manufactures, and sells medical imaging equipment based on photoacoustic technology, and is based in Japan.

2 investors

Quanmatic works on the social implementation and commercialization of advanced technology across enterprise IT, consulting, and autonomous driving fields.

2 investors

RICOS builds RICOS Production Suite, a browser-based platform for machine learning and CAE (computer-aided engineering) simulation, including RICOS Lightning, which uses its proprietary "IsoGCN" machine learning algorithm to predict simulation results and cut computation time, and RICOS Generative CAE, which runs automated design-and-verification loops to search for optimal shapes. It serves manufacturing and product-design engineering teams in the CAE/scientific-computing category.

2 investors

A*Quantum provides "AQCloud," a quantum computing–based AI cloud service with applications for vehicle dispatch/delivery routing, sales activity, and workforce shift scheduling. The company works with enterprises and public bodies in Japan on optimization projects such as aircraft maintenance planning for JAL.

2 investors

Silva Compass develops an AI-driven video conversation system that recreates realistic, human-like dialogue using a person's actual appearance and voice rather than robots or CG. The company positions its technology as a way to deliver relevant information through advanced video and interactive avatar experiences.

2 investors

Kabushiki Kaisha PhoenixBio is a Japanese biotechnology company established in 2002. It operates subsidiaries in the United States, including PhoenixBio USA Corporation and CMHL Consortium LLC.

2 investors

Morpho, Inc. is an imaging technology R&D company founded in 2004 that combines digital image processing with AI and deep learning to create "imaging AI" applications. It develops and commercializes image processing and AI technology across various industry sectors.

2 investors

Ribomic is a company with a U.S. subsidiary engaged in research and development, including pharmaceutical and research-ethics-related activities. The page describes its compliance program, ethics committee, employee training, whistleblower hotline, and management of public research funding.

2 investors

Reborna Biosciences is a Japanese biotech company that researches and develops RNA-targeting small-molecule drugs for hereditary rare diseases. Founded in 2018, it operates from the Shonan iPark research campus.

2 investors

JCCL develops CO₂ capture and recycling technology based on amine-containing gel separation materials and modules licensed from Kyushu University, offering full solutions from R&D to engineering. The company builds CO₂ capture equipment and processes tailored to customers' emission sources in Japan, supporting carbon-neutral and emissions-reduction goals.

1 investor

SIGLEAD (株式会社シグリード) develops error-correction methods and SSD controller LSIs for SSD/NAND flash memory, and offers the SigNAS series of NAND flash memory testers built on its NAND evaluation and error-analysis technology. It also provides signal-processing IP tailored to customer needs.

1 investor

The Innovation World Cup Series is an open innovation competition platform that connects technology entrepreneurs and startups with industry partners and potential investors. Organized by Techprnrs and run in partnership with regional ICT clusters worldwide, it identifies emerging tech applications and investment opportunities across new industries.

1 investor

01.AI builds full-stack enterprise and sovereign AI solutions, including foundation models, industry agents, and decision-support applications for CEOs, executives, investment teams, and B2B/government sales organizations. Founded in Beijing, it offers advisory-led AI transformation with Forward Deployed Engineers alongside its own models and platforms.

1 investor

01 Ventures is a venture capital firm that invests in and operationally supports early-stage deep tech companies across Europe. It focuses on fundamental scientific and engineering advancements in emerging technologies.

1 investor

14bis supplies technology solutions to the aerospace and defense sector, applying blockchain and data analytics to enable connectivity and visibility in complex defense systems.

1 investor

1517 is an early-stage venture capital fund and community that backs college dropouts, uncredentialed founders, and deep-tech scientists from the idea/R&D phase through the seed stage. Founded by cofounders of the Thiel Fellowship, it invests across software, hardware, and deep tech, and also runs a grant program and a global community of hackers, makers, and scientists.

1 investor

ONEsemicon designs memory interface chips for server and client memory modules, including registering clock drivers (RCD) and clock drivers (CKD) for DDR4 and DDR5 RDIMM, CUDIMM, and related applications. Its products are JEDEC-standard-compatible and support data rates up to 9200 MT/s and beyond.

1 investor

1stRound is a startup incubation and growth-support program for teams before their first VC funding round or startups founded within the past three years, co-hosted by Japanese national, public, and private universities, research institutions, and the University of Tokyo Innovation Platform (UTokyo IPC). It selects roughly eight companies twice a year and provides up to 10 million yen in non-equity funding, development resources such as cloud credits and office space, and six months of hands-on support from capitalists and experts.

1 investor

280 Earth develops direct air capture systems that remove CO2 from the atmosphere to address climate change. The company operates a DAC facility in The Dalles, Oregon, and produces fresh water while running on waste heat.

1 investor

2A Biosciences is a stealth-stage biotech developing precision 5-HT2A receptor agonists that activate the body's intrinsic regenerative pathways for nerve regeneration and reduced inflammation. Its platform originates in ophthalmology and is intended to expand into central nervous system and neurodegenerative diseases, and the company is preparing to begin clinical studies.

1 investor

2EyesVision develops SimVis Gekko, a binocular see-through visual simulator that lets patients experience multifocal presbyopia corrections (such as trifocal, EDOF, and intraocular lens options) before undergoing prescription or surgery. It serves eye care professionals in ophthalmology, based on Sim+Vis technology licensed from the Spanish National Research Council (CSIC).

1 investor

2Pi Optics, an MIT spin-off, develops metasurface-enabled flat optics that provide semiconductor-scale optical components with reduced size, weight, power, and cost. Its technology targets AI infrastructure, consumer electronics, automotive, and industrial automation applications.

1 investor