Deep Tech Startups

3D Continuum provides end-to-end digitization and artificial intelligence solutions for maritime and offshore infrastructure assets. The company serves asset owners, operators, contractors, inspectors, financiers, insurers, and regulators seeking more efficient and cost-effective monitoring and delivery of critical infrastructure.

2 investors

3D Controls, founded in December 2014, develops ceramic 3D printing processes and materials, having created its own proprietary process and materials for ceramic 3D printing. The company applies its 3D printing technology to applications such as directly manufacturing dental aligners, positioning it as a lower-carbon alternative to conventional machining.

2 investors

3D Perception develops simulation visual display systems for aerospace, defense, and commercial applications across land, air, sea, and space environments. The company offers turn-key systems, customized solutions, and technology refreshes built on its modular Northstar technology platform.

2 investors

3DGS manufactures glass-based substrate and packaging solutions for miniaturized RF, analog, and digital components in semiconductor and electronics applications. The company serves electronics manufacturers and semiconductor companies requiring advanced packaging, integrated passive devices, and heterogeneous integration technologies.

2 investors

4pi Lab develops remote sensing satellites to detect, monitor, and respond to wildfires and their emissions for climate change mitigation. The company serves organizations and government sectors seeking early wildfire detection and real-time global coverage capabilities.

2 investors

64x provides a platform and product suite for manufacturing advanced therapeutics, including gene therapies, cell therapies, and biologics. The company uses massively parallelized screening and computational insights to engineer high-yield cell lines and production technologies that accelerate the manufacturing of next-generation medicines.

2 investors

8-Fold operates a knowledge ecosystem focused on physical AI, bringing together researchers, engineers, and builders to share ideas and developments in the field.

2 investors

83 Sciences converts unpublished experimental research data into academic papers, patents, and commercialization opportunities for research organizations. The platform captures laboratory data and uses AI to identify valuable findings within discarded experimental datasets.

2 investors

A-metal develops and manufactures compact, affordable 3D metal printers designed to make additive manufacturing accessible to industrial companies without requiring large capital investments, specialized facilities, or expert personnel.

2 investors

Ab Astra is a deep-tech company developing proprietary muon sensors and a data platform that use cosmic-ray muography to non-invasively image the density and internal structure of large subsurface structures. It serves industries such as underground exploration and infrastructure monitoring, offering an alternative to conventional methods that require artificial radiation sources.

2 investors

Abaco designs and manufactures ruggedized computing systems, boards, and networking equipment for defense, aerospace, and industrial applications. The company provides mission-ready subsystems, avionics interfaces, and software tools with long-term support across multiple architectures and form factors.

2 investors

Abbelight provides microscopy equipment, reagents, and services to researchers and biotech labs for studying biology at the molecular level. The company develops bioimaging platforms intended to support advanced diagnostics and therapeutics.

2 investors

AbbraTech develops a platform technology for the discovery, engineering, and validation of antibodies, targeting disease-relevant proteins that are difficult to address with conventional approaches. It works with industry and academic partners to develop antibody therapies for conditions such as cancer, immune disorders, and viral infections.

2 investors

Abselion develops measurement tools and a platform combining hardware, purpose-built assay formats, and software for biological measurements such as protein quantification. It serves scientists and researchers across life sciences, biotech, and therapeutic development.

2 investors

Abyss offers a suite of asset inspection products that integrate with existing operations, workflows, and systems to help organizations manage and inspect their assets at lower time and cost than traditional inspection methods.

2 investors

Accelerated Materials develops microreactor platforms for the synthesis and scaled production of nanomaterials, serving R&D teams and manufacturers moving from laboratory to commercial volumes. The company's continuous-flow reactor systems combine high-shear mixing principles with automated optimization to ensure precise, reproducible nanomaterial synthesis at multiple production scales.

2 investors

AccelR8 is an early-stage venture firm that invests in and helps build climate-focused companies transforming physical industries, backing founders commercializing breakthrough science and engineering to reduce emissions. It typically leads pre-seed and seed rounds for North American teams and is based in Boston with a focus on the New England innovation ecosystem.

2 investors

Accelsius develops NeuCool thermal cooling solutions designed to improve energy efficiency and cooling performance in mission-critical data centers.

2 investors

Accipiter Biosciences uses computational protein design to develop de novo, single-agent protein therapies that engage multiple cell-surface receptors at once, functioning as agonists. Its platform targets complex conditions such as autoimmune disorders and cancer as an alternative to traditional combination therapies.

2 investors

Accutar Biotech applies artificial intelligence to drug discovery, using a hybrid approach of computational drug design followed by wet lab validation to reduce the time and cost of developing new drugs. The U.S.-based company models the physical and chemical properties of biological systems.

2 investors

ACME Capital is a venture capital firm that invests in deep-tech founders across areas such as defense, space, healthcare, and AI. Its portfolio includes companies like Harmattan AI, Canopy, Stendr, Plot, and Muon Space.

2 investors

Acrigen develops precision gene editing systems based on CRISPR, using novel αCas and μCas nuclease libraries paired with engineered anti-CRISPR (ErAcr) proteins to reduce off-target edits. The technology is aimed at human therapeutics for genetic diseases and is offered for licensing.

2 investors

Actinide builds integrated isotope separation systems using advanced simulation, in-house precision manufacturing, and cost optimization to produce atomically precise enriched materials. It targets organizations and strategic partners needing domestic isotope supply for applications in medicine, defense, energy, and advanced materials.

2 investors

ActionStreamer provides enterprise-grade live-streaming software and wearable technology for connected workers, delivering real-time audio and video intelligence through AI-driven insights and intelligent device networks.

2 investors