Data & Infrastructure Startups

Applied Digital builds and operates large-scale data centers purpose-built for AI, machine learning, and high-performance computing workloads. The company designs campuses with high-density, low-latency infrastructure to support next-generation artificial intelligence applications.

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Appriss Retail provides an omnichannel intelligence platform that uses retail data science to protect transactions against fraud and abuse and reduce returns. It serves large U.S. retailers, with the company stating it is trusted by over 60 of the top 100 U.S. retailers.

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AppScale provides AWS API-compatible software that lets organizations run AWS workloads' core APIs in their own data centers or private environments at reduced cost. It targets enterprises seeking hybrid cloud setups, data residency control, air-gapped environments, and avoidance of vendor lock-in.

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AppTech Payments Corp. provides a bank orchestration layer that lets companies open named DDA and FBO accounts and route ACH, wire, RTP, FedNow, and card transactions through a single API and console across a network of chartered banks. The company offers shared compliance infrastructure for regulated payment operations in the United States.

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ArcBlock builds a Layer 1 blockchain that supports decentralized identities (DIDs), verifiable records, and token payments, with ABT as its native token. It offers a runtime (ARC) for building applications as "Blocklets" and a personal data space tied to a user's digital identity.

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Argo Blockchain operates digital infrastructure and cryptocurrency mining operations. The company focuses on blockchain technology adoption and integration of cryptocurrencies into financial systems.

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Argos Risk provides third-party risk intelligence solutions that automate the evaluation and monitoring of commercial vendors' business health and viability. The company uses proprietary algorithms to deliver risk profiles and business performance metrics on millions of businesses globally.

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Aria Networks builds network switches engineered from the ASIC level to capture high-resolution telemetry, combining network, host system, and ML workload signals into a unified context for issue detection. Its intelligence layer supports both human operators and AI agents running continuous investigations across the network.

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Atsign provides technology for privacy and security, device administration, and connectivity, working with system integrators, IT solutions providers, security consultants, platform providers, and device makers. Its offering targets deployment of secure, private connected systems and IoT devices.

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Aurva provides runtime security monitoring that links data access to real identities and context, focused on detecting when legitimate access by AI agents becomes inappropriate. It serves security teams overseeing AI systems that handle sensitive data, operating across the US and Bangalore.

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BioCentury provides news, analysis, and data covering the biotechnology and pharmaceutical industries.

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Baker Street Scientific operates a data intelligence platform that uncovers hidden associations and patterns within large datasets to support decision-making across organizations and industries. The company uses an associative and predictive engine to transform raw data into actionable intelligence for both common and complex business decisions.

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Bancreek Capital Advisors is an investment firm that uses big data and quantitative methods, drawing on information theory, to identify companies with structural advantages and offers actively managed ETFs. It also publishes interactive data visualizations and research tools to make investing insights accessible to individual investors.

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BData operates the Burn Care Quality Platform (BCQP), a burn data platform that captures case-level real-world evidence from U.S. burn centers in collaboration with clinicians and the American Burn Association. It provides benchmarking, quality improvement analytics, product utilization data, and custom data sets to support clinical research and FDA regulatory decision-making for burn care and wound covering products.

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Beyond Data Centers develops and operates custom, hyperscale-focused data center infrastructure for enterprise clients with institutional-grade credit. The company finances, builds, and manages dedicated digital infrastructure tailored to complex compute workloads.

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Biome provides analytics tools for healthcare leaders, focused on improving cardiovascular care outcomes and reducing operational inefficiency. It serves hospitals and cardiac care centers, offering data-driven products including the Biome Performance Network for clinical and operational decision-making.

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BioTuring is a bioinformatics company that builds algorithms and software for analyzing biological data, including single-cell and genomic data. It serves the global scientific research community working to understand biology and improve human health.

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Bit Digital is a holding company that accumulates and stakes Ethereum to generate protocol rewards while maintaining a treasury of digital assets; it also holds a majority stake in WhiteFiber, which operates artificial intelligence and high-performance computing cloud services and data centers globally.

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Bitbison builds a system of record that captures a complete, causal history of activity across systems — from developer workstation through build to production — to enable runtime security detection, policy enforcement and audit. It works at the kernel, networking and storage layer to capture events with low overhead for infrastructure security teams.

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BlockMetrix develops and operates datacenters focused on high performance computing and blockchain. Founded in 2021, the company has operations in the U.S. and is expanding domestically and internationally.

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Blue Orange Digital is a data and AI services firm that builds data engineering, analytics, and generative AI solutions, including agentic systems, for enterprises. It serves Fortune 500 companies, financial institutions, PE-backed portfolio companies, and healthcare organizations.

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Bluewire offers a carrier risk intelligence platform that converts transportation, safety, compliance, insurance, and operational data into a standardized 0–100 GAP Score measuring carrier severity risk. It serves the commercial trucking industry, supporting carrier qualification, underwriting, operational oversight, and fraud detection.

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BluSky AI builds modular, high-performance compute data centers on powered land for AI, machine learning, LLM training, and inference workloads, using NVIDIA H100 GPUs and green energy sources such as geothermal, solar, and wind. It targets AI companies needing scalable compute infrastructure, with sites including a location in Utah, USA.

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Boardroom Alpha provides governance and management-quality analytics on U.S. public companies, offering A–F ratings on executives and directors, daily red-flag monitoring, pay-for-performance analysis, and insider trading signals. It is aimed at portfolio managers, analysts, and asset managers who screen investable universes and monitor holdings for governance events that affect stock prices.

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