Matt Krisiloff
InvestorFounderPartner at SciFounders · CEO at Conception Bio
San Francisco, California
Writes $400K – $1M checks · typically $400K
FoundedConception Bio
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About
Matt Krisiloff is a biotech founder and investor who previously spent most of his career in the software startup world before moving into science company building. He runs SciFounders, a boutique fund focused on founder-led biotech companies, through which he says he has interacted with a couple thousand biotech and health-technology startups over about five years. He is also the founder of Conception, a biotech company he has funded largely with backing from high-net-worth entrepreneur-investors. Across the biotech projects he has run, he says he has personally raised about $100 million, and he writes about biotech fundraising, equity culture for scientists, and the US–China biotech ecosystem.
Contact· published on Matt's own website
Invests in
AI & Machine LearningBiotechDeep TechHardwareHealthtechMedical Devices
Beyond investing
- Founded
- Runs SciFounders, a boutique fund focused on founder-led biotech companies. Founded the biotech company Conception.
- More
- Previously spent most of his career in the software startup world before moving into science company building. Says he has personally raised about $100 million across the biotech projects he has run. Spent two weeks in June visiting Shanghai, Shenzhen, and Hong Kong meeting biotech founders, scientists, investors, and clinicians.
From Matt's own website — common ground for a warm intro.
CEO at Conception Bio
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In turn, Matt can intro founders to Conception Bio's investors below.
Conception Bio's investors · 8
Co-founders at Conception Bio

Investments
Sources: curated public sources · the investor's own website.
Writing
All posts ↗Recent posts focus on biotech startups and founders: observations from a trip through China's biotech ecosystem, advice on fundraising for founder-led biotech companies, and reasons industry scientists should consider starting startups.
The author recounts a two-week trip meeting Chinese biotech founders and investors, finding costs less discounted than expected, company-building less mature than top US firms, and potential for US-China collaboration.
Drawing on raising roughly $100 million, the author explains the current biotech funding landscape, emerging investor categories favoring founder-led companies, and how to tell a compelling, accessible fundraising story.
The author argues industry scientists are well positioned to found startups, citing exposure to real problems, operating experience, co-founder access, and favorable timing during a market downturn.
Colleagues at SciFounders
Frequently asked questions
- Who is Matt Krisiloff?
- Matt Krisiloff is a biotech founder and investor who previously spent most of his career in the software startup world before moving into science company building. He runs SciFounders, a boutique fund focused on founder-led biotech companies, through which he says he has interacted with a couple thousand biotech and health-technology startups over about five years. He is also the founder of Conception, a biotech company he has funded largely with backing from high-net-worth entrepreneur-investors. Across the biotech projects he has run, he says he has personally raised about $100 million, and he writes about biotech fundraising, equity culture for scientists, and the US–China biotech ecosystem.
- Where does Matt Krisiloff work?
- Matt Krisiloff is CEO of Conception Bio and Partner at SciFounders.
- What does Matt Krisiloff invest in?
- Matt Krisiloff invests in AI & Machine Learning, Biotech, Deep Tech, Hardware, Healthtech, Medical Devices.
- What check size does Matt Krisiloff write?
- Matt Krisiloff typically writes checks of $400K – $1M.
- What companies did Matt Krisiloff found?
- Matt Krisiloff founded Conception Bio.
- What companies has Matt Krisiloff invested in?
- Investments tracked here include Bristle, Coherence Neuro, Conception Bio, Instrumentl, Starsky Robotics, The Flex Company.
- What has Matt Krisiloff written?
- Matt Krisiloff has 3 tracked posts on mattkrisiloff.com, including "Chinese Biotech Isn't What You Think", "Fundraising for Founder-led Biotech", "It's a Good Time for Industry Scientists to Start Startups".
Founder mafias
Y Combinator mafia10,594
Also came through, then founded or led a company.
University of Chicago mafia236
Also came through, then founded or led a company.
OpenAI mafia116
Also came through, then founded or led a company.
Preventive mafia2
Also came through, then founded or led a company.
SciFounders mafia2
Also came through, then founded or led a company.
About this profile. Compiled from public sources — SciFounders's own website, press coverage and public professional profiles — and summarised by Fundraising Fox; every fact is kept with where it came from. Spotted an error, or would rather not be listed? Email privacy@fundraisingfox.com · How we build profiles · Your rights




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