Where does Matt Krisiloff work?

Matt Krisiloff is CEO of Conception and Partner at SciFounders.

What check size does Matt Krisiloff write?

Matt Krisiloff typically writes checks of $400K – $1M.

What companies did Matt Krisiloff found?

Matt Krisiloff founded Conception.

What companies has Matt Krisiloff invested in?

Investments tracked here include Conception.

Where did Matt Krisiloff go to school?

Matt Krisiloff studied at University of Chicago.

What has Matt Krisiloff written?

Matt Krisiloff has 3 tracked posts on mattkrisiloff.com, including "Chinese Biotech Isn't What You Think", "Fundraising for Founder-led Biotech", "It's a Good Time for Industry Scientists to Start Startups".

Matt Krisiloff

InvestorFounder

Partner at SciFounders · CEO at Conception

San Francisco, California

Writes $400K – $1M checks · typically $400K

FoundedConception

About

Matt Krisiloff is a biotech founder and investor who previously spent most of his career in the software startup world before moving into science company building. He runs SciFounders, a boutique fund focused on founder-led biotech companies, through which he says he has interacted with a couple thousand biotech and health-technology startups over about five years. He is also the founder of Conception, a biotech company he has funded largely with backing from high-net-worth entrepreneur-investors. Across the biotech projects he has run, he says he has personally raised about $100 million, and he writes about biotech fundraising, equity culture for scientists, and the US–China biotech ecosystem.

Contact· published on Matt's own website

m•••@gmail.comreveal

Invests in

AI & Machine LearningBiotechDeep TechHardwareHealthtechMedical Devices

Beyond investing

Founded: Runs SciFounders, a boutique fund focused on founder-led biotech companies. Founded the biotech company Conception.
More: Previously spent most of his career in the software startup world before moving into science company building. Says he has personally raised about $100 million across the biotech projects he has run. Spent two weeks in June visiting Shanghai, Shenzhen, and Hong Kong meeting biotech founders, scientists, investors, and clinicians.

From Matt's own website — common ground for a warm intro.

CEO at Conception

Intro paths

→

In turn, Matt can intro founders to Conception's investors below.

Conception's investors · 6

age1San Francisco · $500K – $4M checks CompoundNew York · $400K – $1.5M checks HOF CapitalNew York · $25K – $15M checks MetaplanetTallinn · $500K – $10M checks SciFoundersSan Francisco · $1M checks VU Venture PartnersSan Francisco · $200K – $1M checks

Co-founders at Conception

Bianka SeresPresident

Experience

ConceptionCEO and Co-Foundercurrent2018 — presentSan Francisco Bay Area
SciFoundersPartner and Co-Foundercurrent2021 — presentSan Francisco Bay Area
PreventiveCo-Foundercurrent2025 — present
Y CombinatorDirector of Y Combinator Research2015 — 2018San Francisco Bay Area
OpenAIFounding Team Member2015 — 2016San Francisco Bay Area

Investments

Investor

Conception

Per the investor's own website.

Writing

All posts ↗

Recent posts focus on biotech startups and founders: observations from a trip through China's biotech ecosystem, advice on fundraising for founder-led biotech companies, and reasons industry scientists should consider starting startups.

Chinese Biotech Isn't What You Think2026-08-12

The author recounts a two-week trip meeting Chinese biotech founders and investors, finding costs less discounted than expected, company-building less mature than top US firms, and potential for US-China collaboration.

Fundraising for Founder-led Biotech2025-01-07

Drawing on raising roughly $100 million, the author explains the current biotech funding landscape, emerging investor categories favoring founder-led companies, and how to tell a compelling, accessible fundraising story.

It's a Good Time for Industry Scientists to Start Startups2022-11-09

The author argues industry scientists are well positioned to found startups, citing exposure to real problems, operating experience, co-founder access, and favorable timing during a market downturn.

Colleagues at SciFounders

Alexander Schubert

Co-founder at SciFounders

Lucas Harrington

Co-founder and CSO at SciFounders

Frequently asked questions

Who is Matt Krisiloff?: Matt Krisiloff is a biotech founder and investor who previously spent most of his career in the software startup world before moving into science company building. He runs SciFounders, a boutique fund focused on founder-led biotech companies, through which he says he has interacted with a couple thousand biotech and health-technology startups over about five years. He is also the founder of Conception, a biotech company he has funded largely with backing from high-net-worth entrepreneur-investors. Across the biotech projects he has run, he says he has personally raised about $100 million, and he writes about biotech fundraising, equity culture for scientists, and the US–China biotech ecosystem.
Where does Matt Krisiloff work?: Matt Krisiloff is CEO of Conception and Partner at SciFounders.
What does Matt Krisiloff invest in?: Matt Krisiloff invests in AI & Machine Learning, Biotech, Deep Tech, Hardware, Healthtech, Medical Devices.
What check size does Matt Krisiloff write?: Matt Krisiloff typically writes checks of $400K – $1M.
What companies did Matt Krisiloff found?: Matt Krisiloff founded Conception.
What companies has Matt Krisiloff invested in?: Investments tracked here include Conception.
Where did Matt Krisiloff go to school?: Matt Krisiloff studied at University of Chicago.
What has Matt Krisiloff written?: Matt Krisiloff has 3 tracked posts on mattkrisiloff.com, including "Chinese Biotech Isn't What You Think", "Fundraising for Founder-led Biotech", "It's a Good Time for Industry Scientists to Start Startups".