/People

Caleb Appleton

Investor

Partner at Bison Ventures · Board director at cosmon · Board director at Sleuth Insights

San Francisco, California

Writes $250K – $10M checks · typically $5M

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About

Biomedical engineer turned investor focused on techbio and AI applied to the physical world. Previously invested at Innovation Endeavors, served as SVP/GM at TuneIn, and started his career at Bain & Company. Holds a B.S. in Biomedical Engineering from Georgia Tech.

Contact· self-published, not guessed

Invests in

AI & Machine LearningBiotechDeep TechRobotics

Board director at cosmon

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Co-founders at cosmon

RARui Aguiar
Rui AguiarExecutive Officer, Director

Board director at Sleuth Insights

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Experience

  1. Bison VenturesPartnercurrent2024 — presentSan Francisco Bay Area
  2. Bison VenturesInvestor2023 — 2024
  3. The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory UniversityBoard Membercurrent2019 — present
  4. Eikon TherapeuticsSeed Investorcurrent2021 — present
  5. TuneInSenior Vice President and General Manager of Global Subscription Business2021 — 2023
  6. TuneInTechnical Advisor, Chief of Staff to the CEO2021
  7. Innovation EndeavorsSenior Associate2019 — 2021Palo Alto, California
  8. Innovation EndeavorsAssociate2017 — 2019
  9. Bain & CompanyAssociate Consultant2015 — 2017Atlanta
  10. Bao Laboratory at Georgia TechResearch Assistant2011 — 2015Greater Atlanta Area

Skills & more

Entrepreneurship3Venture Capital2Start-ups2Research6Data Analysis10Cell Culture4Biomedical Engineering4Project Management3DNA extraction3Engineering2Technical WritingMathematical Modeling
+10 moreTeachingCross-functional Team LeadershipMammalian Cell CultureBiomechanicsSports BiomechanicsMicrosoft OfficeMatlabMicrosoft ExcelTeam ManagementExperimentation

From Caleb's professional profile.

Deals · 2

cosmonBoard seat

via Bison Ventures · filed May 2026 · $31.7M raise

Sleuth InsightsBoard seat

via Bison Ventures · filed Oct 2025 · $7.9M raise

Attribution from SEC filings, press coverage, and firm rosters.

Other disclosed investments

Investor

$RBOTCitrine InformaticsCobotCosmos InnovationDewpoint TherapeuticsEikon TherapeuticsInner LogicPasskeySkyloSkylo TechnologiesVivodyne

Sources: SEC Form D filings · the firm's website · curated public sources.

Colleagues at Bison Ventures

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Frequently asked questions

Who is Caleb Appleton?
Biomedical engineer turned investor focused on techbio and AI applied to the physical world. Previously invested at Innovation Endeavors, served as SVP/GM at TuneIn, and started his career at Bain & Company. Holds a B.S. in Biomedical Engineering from Georgia Tech.
Where does Caleb Appleton work?
Caleb Appleton is Partner at Bison Ventures and Board director at cosmon and Board director at Sleuth Insights.
What does Caleb Appleton invest in?
Caleb Appleton invests in AI & Machine Learning, Biotech, Deep Tech, Robotics.
What check size does Caleb Appleton write?
Caleb Appleton typically writes checks of $250K – $10M.
What boards does Caleb Appleton sit on?
Caleb Appleton holds tracked board seats at cosmon, Sleuth Insights.
What companies has Caleb Appleton invested in?
Investments tracked here include $RBOT, Citrine Informatics, Cobot, Cosmos Innovation, Dewpoint Therapeutics, Eikon Therapeutics, Inner Logic, Passkey, Skylo, Skylo Technologies, Vivodyne.
Where did Caleb Appleton go to school?
Caleb Appleton studied at Georgia Institute of Technology (Bachelor’s Degree, Biomedical/Medical Engineering).

Founder mafias

Same school

Shared employers