Wellness & Fitness Startups

Senté develops medical-grade skincare products built around its patented HSA (heparan sulfate analog) repair molecule, designed to reduce redness, even skin tone, and support the skin barrier for all skin types including sensitive skin. The dermatologist-recommended, clinically tested formulas are sold direct to consumers through kits, sets, and a personalized skincare quiz.

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Shared Housing Solutions raises capital to buy single-family homes operated as accredited, medically-supported recovery and shared housing for veterans, foster adults, women in transition, and people in recovery from substance use disorder. Tied to the nonprofit Kate's House Foundation, it offers investors passive income through a model funded by local, state, and federal contracts, with operations centered in Seattle, Washington.

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Sinewus positions itself around athletic training, recovery, and injury reduction, though the page provides only a tagline without concrete product details.

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Slice Pickleball operates a pickleball and fitness facility in Twin Falls, Idaho, offering a gym with workout and cardio equipment, free weights, and expert-led exercise classes. It sells monthly and annual memberships to individuals seeking fitness and pickleball activities.

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Sol-ti produces organic, cold-pressed functional beverages including wellness shots (SuperShot), functional drinks (SuperAde), and powder mixes (SuperStix) aimed at daily wellness needs such as energy, hydration, immunity, and digestion. Products are glass-bottled, made in the USA, and marketed as vegan, gluten-free, and kosher.

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Soleil Toujours makes SPF-powered skincare and sun care products designed with sustainable, plastic-reduced packaging and reef-safe, vegan formulations. It is a consumer beauty brand focused on skincare that combines skin protection with environmental sustainability.

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SOLTÉGO is a bio-cosmetics company developing skin care products aimed at protecting and repairing skin from sun-induced damage. Its team includes chemists, formulators, skin pharmacologists, and cosmetic safety experts.

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Soothe operates an on-demand marketplace app that connects consumers and businesses with independent, licensed wellness professionals offering massage, skincare, hair, and beauty services delivered in homes, hotels, and workplaces. It also provides spa/hospitality staffing and employee wellness programs, supported by a nationwide provider network and a SoothePass membership.

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Southern Sky Brands is a medical cannabis company that cultivates, processes, and manufactures cannabis-based medicinal products for patients with debilitating conditions. It operates a 70,000 square foot indoor cultivation and processing facility in Mississippi.

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Sperity Health offers a physician-led preventive health program for employers and individuals, combining advanced diagnostics (labs, screenings, wearables), clinical interpretation, personalized plans, and year-round engagement through a web app. It integrates third-party diagnostics and monitoring devices into one coordinated program tracking metrics like biological age, VO2 max, and a proprietary health score.

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Splash Beverage Group develops and supports a portfolio of consumer beverage brands and is expanding into cannabinoid wellness and lifestyle products. It provides marketing, distribution, and platform resources to help beverage brand founders grow their reach.

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Spoke Sciences develops patented formulation technology that makes lipophilic plant-derived functional ingredients (such as CoQ10, resveratrol, and fat-soluble vitamins) water-soluble and taste-neutral for use in beverages and topical/personal care products. It licenses these proprietary ingredients to consumer products manufacturers, addressing potency, bioavailability, stability, taste, and skin-feel challenges.

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SPORTIME Pickleball operates pickleball facilities with over 120 courts across 13 locations in the Westchester, New York area, offering court reservations, instruction, open play, and competition for players of all skill levels. Select locations feature Save My Play, an AI-powered camera system that records court action for players to review and share.

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Structural Elements operates a franchise network of orthopedic wellness clinics using its proprietary (se) Treatment, a manual therapy and acupuncture method based on fascia mapping, postural alignment, and tensegrity-based assessment. It provides cash-based, root-cause care to patients across a national network of clinics in the US.

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Stryke Club is a dermatologist-formulated personal care and skincare brand designed specifically for boys, offering products such as cleansers. It was co-developed by a board-certified pediatric dermatologist to address gaps in boys' skincare.

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Submersive is developing a spa and bathhouse concept that combines immersive art installations with bathing rituals and neuroscience-informed design, aiming to create therapeutic sensory experiences. It also functions as an R&D effort, testing environments on volunteers using wearables to gather biofeedback, with a first location planned in Austin, Texas.

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SunMed Growers is a cannabis cultivator and producer that grows flower in high-tech Dutch-style greenhouses using natural sunlight and sustainable practices. Its product line includes flower, pre-rolls, vapes, concentrates, edibles, and THC-infused beverages and mocktails.

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TearRestore sells dry eye care products such as warm compress masks, eyelid wipes, artificial tears, and eyelid serums, offered as bundled kits for consumers experiencing dry eye and digital eye strain. The company positions its products as clinically inspired and sold direct to consumers.

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ThinkNow offers a mobile "attention fitness" app that uses short exercises (4 minutes or less) based on neuroscience research to help users improve focus and attention. The product targets consumers seeking to improve mental wellness and performance.

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Three Oaks Hospice is a multi-state provider of hospice and palliative care services for patients and their families, operating one of the larger hospice platforms in the United States following its 2025 merger with Sage. The company grows through strategic acquisitions, de novo expansion and operational integration across multiple states.

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TKO Farms operates a large-scale soursop (graviola) farm in Belize, cultivating and processing soursop fruit, juice, and leaf into powders on-site. It supplies vertically integrated, lab-tested soursop ingredients—including its TKO74 leaf powder line—to formulators making supplements, beverages, and food products.

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Ton Pilates is a reformer Pilates studio in Astoria offering infrared reformer classes, small group classes, and private training. It serves individuals seeking fitness and wellness through leveled, instructor-guided Pilates sessions.

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Topaz develops enzyme-based skin care ingredients that selectively reduce harmful bacteria while preserving beneficial bacteria to rebalance the skin microbiome, targeting conditions such as eczema and acne. It uses a proprietary metagenomics platform and synthetic biology to discover and design enzymes derived from natural microbial diversity.

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Trainiac operates a platform that pairs individuals with certified personal trainers who provide personalized workout programming, ongoing accountability, and support to help users build lasting fitness habits. The service is aimed at busy people who want human coaching they can follow on their own schedule rather than app-based algorithms.

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