Medical Devices Startups

OnPoint Vision designs, develops, and manufactures intraocular lenses (the AccuraSee IOPCL) that correct residual refractive error in patients who have already undergone cataract surgery, with additional focus on patients experiencing vision decline from age-related retinal conditions such as macular degeneration. The company's minimally-invasive implantable lens targets the ophthalmic and vision-correction medical device market.

1 investor

Onsite Dental delivers dental care services in customized practice locations within workplaces, college campuses, and residential buildings. The company operates traditional fixed sites, mobile practices, and pop-up clinics, focusing on accessibility and patient comfort.

1 investor

ONWARD Medical develops non-invasive and investigational spinal cord stimulation therapies to restore hand sensation, strength, and function in people with spinal cord injury. Its FDA-cleared, CE-marked medical devices are used by rehabilitation professionals in clinics and by patients at home.

1 investor

ONYA Therapeutics develops investigational pharmaceutical treatments for chronic and acute wounds, using a patented silicone-based patch that stabilises and delivers a well-characterised active compound to modulate wound exudate and restart healing. Its lead programme OTX-PP01 targets chronic wounds such as diabetic foot ulcers, with additional variants planned for battlefield trauma and cancer-related wounds.</parameter> <parameter name="founders">[{"full_name": "Thomas Hafner", "title": "CEO & Founder"}]

1 investor

Opal Therapeutics develops organoid models and therapies centered on female biology to improve drug discovery outcomes in women's health. The company addresses the underserved space of female-specific drug development by building human-relevant models that better capture female biological characteristics.

1 investor

Open Bionics develops 3D-printed bionic hands called the Hero Arm, designed to be affordable, functional, and aesthetically appealing alternatives to traditional prostheses. The company serves individuals with upper limb differences and limb loss, operating in the medical devices and assistive technology space.

1 investor

Open Stent Solution develops a percutaneous medical device for mitral and tricuspid valve replacement in cardiac patients ineligible for open-heart surgery. The company leverages ribbon-based valve technology to enable less invasive treatment with smaller delivery systems adaptable to various valve sizes.

1 investor

OpenBiome Foundation advances microbiome-targeted therapies for serious conditions like Clostridioides difficile through partnerships, innovation funding, and open-access research tools. The organization works to expand patient access to microbiome treatments while accelerating scientific discovery in the field.

1 investor

OpenClinica eConsent is a digital consent platform for clinical trials that enables participants to review and electronically sign informed consent forms using media-rich content on any device. It serves academic researchers, sponsors, contract research organizations (CROs), and clinical trial sites who need to streamline enrollment while maintaining regulatory compliance across decentralized, hybrid, and in-person studies.

1 investor

OpenNeuro (COSMIIC System) provides an open, FDA-tested neuromodulation hardware platform — including implantable devices, PCB designs, firmware, and regulatory documentation — that takes therapies from benchtop kits to animal-grade and human-grade implants for first-in-human studies. It serves neuromodulation researchers, biomedical engineers, and startups developing implantable therapies for conditions such as paralysis, chronic pain, incontinence, and autonomic disorders, with deployments across the US and Europe.

1 investor

A developer of patient simulation platforms and healthcare training solutions for hospitals, medical schools, first responders, and military personnel seeking hands-on surgical and emergency medical education.

1 investor

OPExPARK uses IoT technology to digitize operating rooms and standardize surgical practices globally. The company provides platforms for real-time surgical data integration, digital surgical education, and smart recording solutions for surgeons and medical institutions.

1 investor

OPIRIS develops multimodal optical imaging systems that sense across multiple spectral ranges (UV through LWIR) for applications including target detection in degraded visual environments, metrology for semiconductor and metasurface manufacturing, and non-invasive medical imaging for rheumatology and oncology.

1 investor

OPKO Health is a fully integrated healthcare company developing multispecific therapies for serious diseases including cancers and infectious diseases, and operates BioReference Laboratories, a clinical reference laboratory serving approximately 11 million patients annually in the U.S.

1 investor

OPN Healthcare (Oncology Physicians Network) is a technology-enabled specialty healthcare services company and Management Services Organization focused on cancer care. It coordinates between payers/risk-holders and oncologists to support value-based community oncology care across US regions.

1 investor

OpSens Medical develops sensor-guided medical devices, including fiber optic guidewires and hemodynamic monitoring systems, for use in interventional cardiology procedures.

1 investor

A service that recruits customers seeking orthodontic braces through social media and refers them to dental clinics. It operates across multiple prefectures in Japan, serving orthodontic dental clinics.

1 investor

Optalert is a medtech company that detects drowsiness and cognitive impairment using its proprietary Johns Drowsiness Scale algorithm based on eyelid movement measurement. The company serves mining, transport, and automotive sectors with fleet management and driver monitoring solutions, and is developing early screening methods for sleep apnea and neurodegenerative conditions.

1 investor

Optegra operates dedicated private eye hospitals offering ophthalmic diagnostics, cataract and laser eye surgery, and aftercare delivered by NHS-trained consultant surgeons. It serves private and NHS eye-care patients, providing free video or telephone consultations and personalised treatment plans.

1 investor

Opticyte develops the VitalO₂, a preclinical-stage medical device aimed at hospitals, with an FDA De Novo pathway and Breakthrough Device Designation. The company operates in the medical device sector.

1 investor

OptimalPSI develops patient-specific spinal fusion implants (TLIF) designed with an optimization algorithm that accounts for each patient's bone structure and load distribution to reduce subsidence risk. An ETH Zürich spin-off, it serves spine surgeons treating lumbar fusion patients at risk of post-operative subsidence.

1 investor

Optina develops a retinal imaging and AI platform for diagnosing and managing Age-Related Macular Degeneration in eye care specialists and patients. The platform combines hyperspectral imaging technology with AI clinical decision support to improve early detection and disease monitoring.

1 investor

Optina develops a retinal imaging and AI platform, combining an FDA 510(k) cleared hyperspectral camera with AI to help eye specialists diagnose and manage Age-Related Macular Degeneration and other retinal disease. The platform supports early, intermediate, and late-stage detection, risk monitoring, and tracking of therapeutic effectiveness in at-risk patients.

1 investor

Optinose is a specialty pharmaceutical company that develops and markets products for patients with conditions treated by ear, nose, and throat (ENT) and allergy specialists. Its lead product, XHANCE (fluticasone propionate), uses the company's patented Bi-Directional Exhalation Delivery System (EDS) to deliver medication deep into the nasal passages.

1 investor