Longevity Startups

Seen Health operates a PACE-style program combining clinical care, home help, care concierge, and a community center for seniors, with a focus on serving families within specific cultural communities. It provides on-site medical appointments, rehabilitation, activities, and meals, and may be free or low cost for eligible seniors.

1 investor

Senior Helpers provides in-home senior care across the United States, offering services from companion assistance with daily activities to specialized care for chronic conditions. It serves seniors and their families, including those with Alzheimer's, dementia, and Parkinson's disease.

1 investor

Senior Service provides non-medical home care and supplementary informal-care support for elderly people in the Netherlands, ranging from weekly companionship to 24-hour care, helping seniors continue living at home. It matches clients with fixed employed caregivers and coordinators, and advises on financing routes such as insurance, PGB, Wlz and Wmo.

1 investor

Senotherapeutix (d/b/a Gerotherapeutix) develops gerotherapeutics based on its MitoXcel geropeptide platform, which targets mitochondrial mechanisms of cellular aging to improve healthspan and extend lifespan. The company operates three subsidiaries spanning longevity therapeutics (Eos Senolytix), oncology peptides (Perseus Senolytix), and controllable gene therapies (Phoenix Senolytix).

1 investor

Serenity Smart provides a voice-first platform with automated workflows and real-time communications for older adults, giving seniors access to information by voice, automating daily care routines, and connecting senior living, home health, hospice, pharmacy, and family members. It supports features like video calling and e-form signing to coordinate care across providers and families.

1 investor

Shift Bioscience develops siRNA therapeutics for cell rejuvenation, using a target identification platform that has identified an anti-fibrotic candidate initially aimed at liver fibrosis. The company works in the aging and longevity biotech field, having discovered novel aging targets linked to disease states.

1 investor

Solaria develops plant-sourced living synbiotics (probiotic-prebiotic products) marketed as medical foods for inflammatory conditions, starting with Bōndia for bone loss in women with osteopenia and a forthcoming product, Arthrīva, for rheumatoid arthritis. The company builds a library of plant-based microbiome solutions backed by clinical trials and a Harvard Medical School partnership.

1 investor

Spark Health is a healthcare practice offering personalized primary care that combines conventional and natural medicine. It provides individualized assessments, diagnostic testing, and holistic treatment plans aimed at identifying root causes of health conditions and supporting long-term wellness and longevity.

1 investor

TMRW is a health membership service focused on helping members live longer and healthier through integrative, clinician-led care. It combines medical practitioners, health coaches, and bioinformatics to support personal health and longevity.

1 investor

StemBioSys develops cell culture technology, including the patented CELLvo Matrix that replicates the body's physiological microenvironment to expand mesenchymal stem cells and specialty cells while preserving their stem-like properties. It supplies cells and cell expansion tools for stem cell research and regenerative medicine applications.

1 investor

Sunday Health is a medical practice providing preventive, diagnostic, and ongoing cognitive care for older adults, focused on memory and brain health. It delivers care through virtual video and phone visits (plus in-person appointments in Vienna, VA) via a care team of neurologists, geriatric nurse practitioners, and care navigators, serving patients in DC, Maryland, and Virginia.

1 investor

Symbiont Health builds a fall-detection system that uses a mesh network of Wi-Fi routers to detect falls without pendants, wearables, or body sensors, and shares vital signs and medication information with caregivers. Its AI-based analytics provide patient behavior statistics for use in elderly and memory care communities.

1 investor

SYNERGY HomeCare provides non-medical in-home senior care nationwide, with trained caregivers assisting older adults with daily needs like meals, mobility, bathing, transportation, and companionship. It also offers specialized support for people with Alzheimer's, memory loss, stroke recovery, chronic conditions, and post-hospital transitions.

1 investor

System Labs sells premium peptide treatments sourced from licensed U.S. pharmacies, pairing customers with a licensed clinician who guides them through treatment via an online intake flow. Its products, such as NAD+ and glutathione, are aimed at supporting performance and longevity, with medications compounded by certified U.S. pharmacies.

1 investor

TAG Therapeutics develops TELOBLOCK, an antisense nucleotide therapy that inhibits the DNA damage response at short or damaged telomeres to reduce cellular senescence, targeting telomere biology disorders and age-related diseases such as idiopathic pulmonary fibrosis and bone marrow failure. The company also explores ex-vivo applications to improve immune cell fitness for bone marrow transplantation and cancer immunotherapies.

1 investor

TAZ develops anti-aging products and drug discovery research focused on cellular senescence removal and longevity science. The company provides biomarker testing services, contract product development, and drug candidates to extend healthspan in an aging society.

1 investor

Telomere Therapeutics is a gene therapy company developing treatments that repair telomeres to address organ fibrosis and telomere-dysfunction syndromes. Its lead program is an AAV-based therapy for idiopathic pulmonary fibrosis (IPF).

1 investor

Tertianum operates senior living residences and care homes in Switzerland, offering apartments and assisted living for elderly residents. It focuses on providing a supportive living environment for seniors making the transition to age-appropriate housing.

1 investor

The Well Estate develops wellness-focused hospitality concepts, partnering with hotels and hospitality operators to add wellness-oriented guest experiences and new revenue streams. The company positions itself around extending human healthspan through fitness and lifestyle offerings.

1 investor

Thunder Biotech is a cancer immunotherapy company developing MOTO-CAR treatments, which genetically engineer a patient's own macrophages into chimeric antigen receptor cells that target biomarkers on tumor cells to attack solid tumors. It focuses on immunotherapy for cancer patients with solid tumors.

1 investor

Twinn Health provides preventive whole-body MRI infrastructure, offering AI-structured reporting and longitudinal health data for imaging providers and wellness clinics, plus expert MRI interpretation support for individuals. Originating from research at Imperial College London, it focuses on early disease detection in emerging longevity markets across the UK and the Middle East.

1 investor

Vandria develops first-in-class orally available small molecules targeting a novel metabolic pathway to improve mitochondrial function and reduce chronic inflammation for age-related and chronic diseases of the CNS, muscle, lung, and liver. Its lead clinical asset, VNA-318, is a small molecule for CNS indications that has completed Phase I studies.

1 investor

Vascugen develops an induced-pluripotent stem cell (iPSC)-derived vasculogenic cell therapy intended to form new blood vessels and restore microvascular circulation in oxygen-starved tissues. It targets diabetic and arterial disease patients at high risk of limb amputation, and handles development from R&D through cGMP manufacturing.

1 investor

Ventuno Biotech develops cancer immunotherapies that use the immune system to target and eliminate cancer cells in difficult-to-treat tumors. The company is based in Lyon, France.

1 investor