Longevity Startups

One Senior Care supports PACE (Program of All-Inclusive Care for the Elderly) programs with administrative services, technology, and expert access so partner programs can focus on caring for seniors. It focuses on serving seniors in rural, underserved, and Appalachian communities in the US.

1 investor

OneStX develops medicinal products aimed at preventing, slowing, or suppressing the progression of neurodegenerative diseases such as Alzheimer's. Its approach is based on steroid sulfatase inhibition, which has shown improvements in lifespan and memory in C. elegans and mouse models.

1 investor

OptiChroniX is a Swiss digital health company whose Rejuvify system provides a daily prioritization framework to preserve functional muscle and lean mass during weight loss, aging, and lifestyle changes. It uses real-world data such as body composition, activity, and behavior to focus users each day on protein intake, resistance stimulus, or recovery.

1 investor

Orange Grove Bio is a biotech venture firm that builds and backs cell therapy and immuno-oncology companies, forming subsidiary companies (subcos) such as Ipinovyx and DomainOne Therapeutics. It operates in the biopharmaceutical and life sciences investment space.

1 investor

Peak Health offers doctor-led longevity care combining advanced diagnostic testing (labs, biomarkers, DEXA scans, VO2 max) with personalized treatment plans including hormones, peptides, GLP-1s, supplements, nutrition, and fitness, all managed through a single health data platform. It serves consumers seeking proactive aging, hormone optimization, and disease prevention, and also offers infrastructure for clinical practices to launch or expand longevity programs.

1 investor

Pelagos Pharma is a therapeutics developer working on "exercise mimetics," drug candidates designed to activate the metabolic, mitochondrial, and structure-function pathways associated with the benefits of aerobic exercise. The company targets diseases linked to aging and increasingly sedentary lifestyles.

1 investor

Perseus SENOLYTIX is an oncology company developing MitoXcel oncopeptides, sequence-engineered peptides that target cancer cells through mitochondrial membrane potential rather than receptor- or kinase-based mechanisms. It pursues first-in-class treatments for hematologic and solid tumors, with preclinical activity shown in leukemia, lymphoma, melanoma, and breast cancer models.</parameter> <parameter name="hq_city">Houston

1 investor

Phoenix SENOLYTIX is a longevity biotech developing controllable gene therapies that target the biological mechanisms of aging, based on its ApoptiCIDe-CE and ApoptiCIDe-RGT platforms and a proprietary cell-elimination switch triggered by a reformulated small molecule. Its programs aim to eliminate senescent cells and adipocytes and to regulate gene-therapy-delivered proteins for aging-related disorders and cancer.

1 investor

Pihlakodu operates modern nursing and care homes in Estonia, offering general care, round-the-clock nursing, home care, dementia care, and physiotherapy services. It serves elderly people and adults needing assisted living, with locations including Kristiine, Tartu, and an upcoming facility in Ülemiste City.

1 investor

Ponce Aurora is a longevity company, affiliated with GEROTHERAPEUTIX, that develops cosmetics, beverages, and supplements designed to counteract aging and boost energy using licensed MitoXcel geropeptide technology. Its lead products include the YUUTH Full Body Treatment cosmetic and the YUURN Boost energy beverage.

1 investor

Ponce Aurora is a longevity company developing cosmetics, beverages, and supplements that target aging-related cellular issues using proprietary geropeptide technology. The company's lead products include YUUTH™, a topical full-body treatment marketed for skin and body rejuvenation, and YUURN Boost™, a beverage designed to provide sustained energy without caffeine-like side effects.

1 investor

PRD Therapeutics is a drug-discovery startup developing first-in-class oral SOAT2-selective inhibitors (PRD compounds derived from pyripyropene A) to regulate lipid metabolism. Its lead program targets the rare disease homozygous familial hypercholesterolemia (HoFH), with planned expansion to MASH/MASLD and other lipid-metabolism disorders.

1 investor

Preamble provides proactive, personalized health management combining comprehensive diagnostics (100+ biomarker blood panels, DEXA body composition, cardiac and fitness assessments), physician-interpreted health reports, and long-term coaching to extend clients' healthspan and lifespan. It offers membership-based preventive care that complements primary care for individuals focused on longevity and optimizing their health.

1 investor

Proxima Health offers blood diagnostics to detect environmental toxins such as microplastics, PFAS, and heavy metals, alongside lifestyle protocols and blood filtration interventions to remove them. It targets consumers concerned about environmental toxin exposure in the health and wellness space.

1 investor

Pure MHC is a drug discovery and development company using platform technology focused on HLA Class I and Class II target identification and validation, and provides contract research services in mass spectrometry, proteomics, peptidomics, epitope screening, and soluble HLA protein production. It develops immunotherapeutics and supports investigators working on cancer, infectious, and autoimmune diseases.

1 investor

Refoxy is a science-driven company focused on drug discovery, medicinal chemistry, and bioinformatics. The team page emphasizes deep science and collaboration, but the page provides only placeholder text about the company's specific work.

1 investor

Remedium Bio is a biotech company developing gene therapy and biologic treatments for osteoarthritis and other rheumatology and metabolic conditions, drawing on research into cartilage regeneration and the FGF18 protein. Its work targets diseases such as osteoarthritis, arthritis, and diabetes-related metabolic conditions.

1 investor

Rendever is a virtual reality platform designed for seniors in senior living communities, offering shared VR experiences, reminiscence therapy, live programming, and a fitness product (RendeverFit) to reduce social isolation and improve wellbeing. It serves residents, caregivers, and their families across senior living and care settings.

1 investor

Response Pharmaceuticals is a clinical-stage drug developer working on RDX-002, a small-molecule iMTP inhibitor for weight management and metabolic health, including post-GLP-1 receptor agonist weight management and antipsychotic-induced weight gain. The company is advancing the candidate through Phase 2 clinical trials.

1 investor

Restore Hyper Wellness operates a nationwide chain of 210+ wellness studios in the US offering science-backed therapies such as cryotherapy, red light therapy, infrared sauna, IV drip therapy, hyperbaric oxygen therapy, facials and medical weight-loss plans. Each studio has clinical oversight from nurse practitioners and serves consumers focused on recovery, performance, longevity and skin health.

1 investor

Ribogenyx develops first-in-class therapeutic enhancers of translational fidelity, targeting mRNA translation processes for precision medicine. Its focus is on age-related diseases and mechanisms of stress resilience mediated by mRNA translation.

1 investor

Sage provides a nurse call and caregiver alert system for senior living and care facilities, capturing resident data and generating recommendations to help staff detect changes in condition and support clinical decisions. The platform is used by caregiving teams to respond to resident requests and quantify care efforts.

1 investor

Savoy Life provides a geriatric-trained care team that works onsite with senior living communities to integrate caregiving with healthcare. It serves senior living communities and their residents in the elder care market.

1 investor

SciNeuro develops targeted therapeutics for neurodegenerative and age-related brain diseases by integrating patient genetics, health history, and advanced diagnostic tools. The company collaborates with scientific institutions to create disease-modifying therapies addressing aging populations' neurological challenges.

1 investor