Healthtech Startups

Specialty1 Partners is a business serving specialty dental practices, offering partnership and practice growth support through collaborative networking and operational services for specialist dentists.

1 investor

Specialty Smile Partners operates a network of pediatric dentistry and orthodontic practices across the Midwest, providing support, mentorship, and operational management to specialty dentists. The organization prioritizes doctor and team well-being alongside clinical quality and patient experience.

1 investor

Specialty Medical Partners provides operational and administrative support services to medical practices, allowing physicians to focus on patient care.

1 investor

Specific Biologics develops in vivo genome editing therapeutics based on its Dualase editors, which use a two-site mechanism to remove, repair, or insert DNA sequences, with an initial focus on correcting expanded DNA repeats. Its pipeline targets CNS, lung, and liver genetic diseases using single AAV or lipid nanoparticle/polymer-encapsulated all-RNA delivery.

1 investor

Speckles manufactures adhesive eye patches designed for children undergoing occlusion therapy for amblyopia, developed by eye care professionals. The patches feature soft, hypoallergenic materials and are available in themed designs.

1 investor

Spectacle is a white-labeled ICHRA (Individual Coverage Health Reimbursement Arrangement) administration platform for benefits brokers and agencies, covering quoting, enrollment, reimbursement, payroll integration, and compliance. It provides carrier, hospital, and cost data across US states along with a multilingual, voice-enabled enrollment tool to help employees choose marketplace health plans.

1 investor

Spectramedix develops cloud-based analytics applications for healthcare organizations to improve patient outcomes and reduce care costs. The company serves healthcare systems and networks across North America and globally.

1 investor

SpectronRx develops and manufactures theranostic and diagnostic molecular isotope products (radiopharmaceuticals), operating research and production facilities including cyclotron sites. The company serves the nuclear medicine market and is headquartered in the central US, with facilities in Fishers and South Bend, Indiana.

1 investor

Spectrum.Life provides integrated digital health and wellbeing services to organizations and their employees, covering medical care, mental health support, and personalized coaching. The platform serves employers, educational institutions, and healthcare systems seeking comprehensive health management solutions for their populations.

1 investor

Spectrum Spine develops spinal and orthopedic medical devices, including its FDA-cleared BioBraille nanotechnology.

1 investor

Spectrum Disinfection is a development-stage chemistry company developing a patented chlorine dioxide technology that stabilizes an industrial disinfectant for consumer and commercial use. Its first surface disinfectant is pending EPA approval, with additional disinfection products planned for industrial and commercial markets.

1 investor

SpeechLink offers Speech Motor Chaining, a tool that generates evidence-based speech sound therapy practice sessions for speech-language pathologists and their clients. It includes PERCY, an AI clinician assistant that provides feedback to learners at home and automatically collects progress-monitoring data for reporting.

1 investor

1 investor

A medical device company that translates scientific findings into life-saving medical products, operating under strict quality and compliance standards. The company develops and manufactures medical technologies in Germany.

1 investor

SpeeDx develops PCR-based diagnostic tests for sexually transmitted infections that detect pathogens and antibiotic resistance markers, enabling clinicians to make informed treatment decisions. The tests are designed for use with standard laboratory equipment in clinical settings.

1 investor

SpendAble provides a secure payment system and debit card designed for people with disabilities and elderly individuals to manage their finances independently. The platform allows caregivers and care managers to access funds and monitor spending while protecting account holders from financial abuse and fraud.

1 investor

SpendMend provides cost-cycle management solutions to hospitals and health systems, helping them identify and recover financial savings while improving operational visibility. The company serves over 150 major U.S. health systems spanning 4,000+ locations.

1 investor

SpendRule provides a contract intelligence platform that automates the validation and enforcement of purchased services contracts in healthcare. The platform validates invoices line-by-line against contract terms before payment, identifies savings opportunities, and maintains a centralized record of monitored spend.

1 investor

Spentys provides design automation and collaborative tools for orthopedic and manufacturing teams to streamline the design-to-production workflow for custom-made medical devices and orthoses. The platform integrates digital design with manufacturing processes, offering automated quality checks and compliance tracking for healthcare and medical device production.

1 investor

Speratum Biopharma develops RNA interference (RNAi) therapeutics for cancer and other hard-to-treat genetic diseases, using its proprietary NoPass RNAi design platform and Nano-In nanoparticle delivery system. Its lead candidate, NM-198, is based on the tumor-suppressor microRNA miR-198 and targets multiple oncogenic pathways in solid tumors.

1 investor

Spero Therapeutics is a clinical-stage biopharmaceutical company developing next-generation immunology and inflammation medicines, particularly targeting patients with serious diseases and major treatment gaps. The company's lead program, SP001, is a novel anti-CD40L monoclonal antibody being advanced in IgG4-related disease and other immune-related conditions.

1 investor

SphereBio develops individualized cancer immunotherapies using engineered biological vesicles (OncoSpheres™) that capture a patient's own tumor antigens and deliver them into immune cells to train the immune system against cancer. The company combines biotechnology, synthetic virology, and AI to create individualized cancer vaccines manufactured without sequencing in under seven days.

1 investor

Spherix Global Insights provides independent syndicated market research and intelligence for pharmaceutical and biotech companies, combining primary research across physicians, patients, and payers with therapeutic expertise and AI-assisted execution. Its data supports commercial decisions and is used in investor reviews and board conversations.

1 investor

SphingoTec develops proprietary biomarkers for critical care diagnostics, addressing acute kidney injury, sepsis, and acute heart failure through partnerships with in vitro diagnostics companies and pharmaceutical firms. The company licenses its biomarker portfolio to global IVD partners to make clinical diagnostic products available worldwide.

1 investor