Healthtech Startups

SI-BONE develops medical devices for treating sacroiliac (SI) joint dysfunction and chronic low back pain, targeting patients and physicians. Its main offering is a minimally invasive implant system used for SI joint fusion surgery.

2 investors

Sibel Health develops medical monitoring products that capture vital signs and health data to support clinical decisions in both patient care and clinical trials. Its technology is aimed at improving decision-making for drug safety, efficacy, and clinical treatment.

2 investors

Sifio Health develops an integrated digital platform using machine learning and predictive analytics to optimize surgical workflows and care management for healthcare providers. The platform aims to reduce operational inefficiencies and enable care teams to focus on patient care rather than administrative tasks.

2 investors

Sigmatic builds software tailored to the operational and financial workflows of ambulatory surgery centers (ASCs), aimed at provider-owned organizations. The product is positioned to fit existing ASC workflows rather than replace them.

2 investors

Sign on Tab develops digital document management software with legally binding digital signatures and biometric data capture, offering products such as digital templates, a virtual printer, cloud storage, and API integrations. A division of ITO Group serving over 220 business customers, its largest client base is in the healthcare sector, where it supports patient onboarding and data management.

2 investors

Signal Fusion provides AI-powered behavioral and voice analytics that convert human signals into predictive intelligence for safety, readiness, and performance monitoring in high-stakes industries. The platform identifies subtle human-state changes like stress and coordination drift to prevent accidents and improve operational integrity across maritime, transportation, construction, mining, manufacturing, healthcare, energy, and utilities sectors.

2 investors

Signant Health provides software platforms and clinical trial solutions for life sciences companies to manage patient-reported outcomes, evidence generation, and digital endpoints in drug development programs across multiple therapeutic areas.

2 investors

Signum Technologies develops artificial intelligence and computer vision solutions in collaboration with U.S. National Laboratories and Federal Agencies to address critical challenges in healthcare, security, and national defense. The company commercializes advanced biosensor and imaging technologies originally developed for urgent public health and security needs.

2 investors

SiiPet manufactures pet monitoring camera accessories, specifically a gooseneck holder that clips onto litter boxes or nearby surfaces to position cameras at adjustable angles for pet observation.

2 investors

Siloam Vision develops medical imaging and software solutions for eye care, with initial focus on retinopathy of prematurity (ROP) in premature infants. The company offers hardware (scanning laser ophthalmoscope and OCT systems) and AI-assisted software platforms for ophthalmologists and eye care providers worldwide.

2 investors

Simbie AI builds healthcare workflow management software for clinical practices, automating scheduling and documentation to reduce administrative burden on providers and improve patient care.

2 investors

Clify develops a multimodal AI solution using facial recognition and voice analysis to assess mental state and evaluate candidates through biometric data. The FAV (Face & Voice) platform is designed for talent assessment and recruitment using real-time facial microexpression and voice analysis rather than surveys.

2 investors

Simuhealth provides digital infrastructure for healthcare simulation operations, offering a unified system to track and coordinate scenarios, learners, staff, rooms, and equipment. It targets simulation programs that otherwise rely on disconnected systems and manual coordination.

2 investors

Sincrolab offers a personalized digital treatment to improve attention and focus in children, delivered at home through a gamified app (Sea of Heroes) with daily 15-minute activities and professional supervision. It targets families whose children struggle with concentration and task completion, providing online evaluation and ongoing clinical follow-up over a six-month program.

2 investors

Singular Medical develops implantable cardiac devices and digital health solutions for arrhythmia and heart failure management, including pacemakers, defibrillators, and remote monitoring systems. The company serves hospitals and patients in China and developing markets with products spanning screening, diagnosis, treatment, and monitoring across implant and AI domains.

2 investors

Sirius NeoSight develops a patented technology that measures cell membrane fluidity using a fluorescent molecule to detect, isolate and characterise Circulating Tumour Cells (CTCs) from blood samples. Aimed at oncologists, the technology supports early cancer detection, monitoring of recurrence and treatment resistance, and personalised therapy selection for metastatic and aggressive cancers.

2 investors

Sirius Therapeutics is a biopharmaceutical company developing siRNA-based therapeutics, including work in the anti-coagulant therapeutic area. It focuses on drug discovery and clinical development of RNA-based medicines.

2 investors

SiSaf is an RNA delivery and therapeutics company that uses its proprietary bioabsorbable silicon-based Bio-Courier technology to deliver nucleic acids, avoiding the ultra-cold supply chain of conventional lipid nanoparticles. It is developing a pipeline of RNA therapeutics targeting pancreatic cancer, metastatic cancer, and the rare skeletal disease osteopetrosis ADO2.

2 investors

Skeletalis is developing OASIS, a targeted small-molecule platform for musculoskeletal and bone health that concentrates therapy at sites of active bone loss while preserving the body's natural bone remodeling. The company translates bone biology research into therapies designed to protect and rebuild bone.

2 investors

SkinCheck develops a computer vision AI app that analyzes skin images to detect potential signs of skin cancer early, providing users with instant feedback and recommendations. It is designed to work across all skin colors and is aimed at individuals globally, with a focus on reducing health inequity in skin cancer detection.

2 investors

2 investors

Skylabs makes CART BP, a ring-shaped blood pressure monitor worn on the finger that automatically measures systolic/diastolic blood pressure and pulse using PPG (photoplethysmography), including during sleep. It is a certified medical device aimed at people managing hypertension at home, with data synced to a companion app for daily, weekly, and monthly tracking.

2 investors

Skylight Health provides technology and services to improve specialty care delivery across the healthcare ecosystem, connecting patients, providers, and payers.

2 investors

Sleep Easy Technology makes the Oxyllow System, an oxygen pillow that serves as an alternative to nasal cannulas for people receiving supplemental oxygen therapy during sleep. The product targets patients seeking a more comfortable option for oxygen therapy at night.

2 investors